| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 11,572,125 | 52,190,000 | 20.06% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 8,883,851 | 40,066,000 | 15.40% | ||
| 3 | ORBIMED ADVISORS LLC | 6,000,400 | 27,062,000 | 10.40% | ||
| 4 | BAKER BROS. ADVISORS LP | 3,475,672 | 15,675,000 | 6.03% | ||
| 5 | JANUS HENDERSON INVESTORS US LLC | 3,202,427 | 14,443,000 | 5.55% | ||
| 6 | ARMISTICE CAPITAL, LLC | 2,846,000 | 12,835,000 | 4.93% | ||
| 7 | BlackRock Fund Advisors | 2,349,213 | 10,595,000 | 4.07% | ||
| 8 | VANGUARD GROUP INC | 2,257,792 | 10,182,000 | 3.91% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,669,352 | 7,529,000 | 2.89% | ||
| 10 | ASYMMETRY CAPITAL MANAGEMENT, L.P. | 1,627,628 | 7,340,000 | 2.82% | ||
| 11 | Broadfin Capital, LLC | 1,592,067 | 7,180,000 | 2.76% | ||
| 12 | J. Goldman & Co LP | 1,367,558 | 6,168,000 | 2.37% | ||
| 13 | Rock Springs Capital Management LP | 1,100,000 | 4,961,000 | 1.91% | ||
| 14 | STATE STREET CORP | 975,352 | 4,399,000 | 1.69% | ||
| 15 | ROYCE & ASSOCIATES LP | 846,200 | 3,816,000 | 1.47% | ||
| 16 | NATIXIS | 717,900 | 3,238,000 | 1.24% | ||
| 17 | NORTHERN TRUST CORP | 691,936 | 3,120,000 | 1.20% | ||
| 18 | ALTRINSIC GLOBAL ADVISORS LLC | 606,645 | 2,736,000 | 1.05% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 389,911 | 1,758,000 | 0.68% | ||
| 20 | TIAA CREF INVESTMENT MANAGEMENT LLC | 328,102 | 1,480,000 | 0.57% | ||
| 21 | Bank of New York Mellon Corp | 305,067 | 1,375,000 | 0.53% | ||
| 22 | DEUTSCHE BANK AG\ | 289,818 | 1,306,000 | 0.50% | ||
| 23 | State of New Jersey Common Pension Fund D | 249,082 | 1,123,000 | 0.43% | ||
| 24 | MILLENNIUM MANAGEMENT LLC | 248,496 | 1,121,000 | 0.43% | ||
| 25 | BlackRock Investment Management, LLC | 213,128 | 961,000 | 0.37% | ||
| 26 | D. E. Shaw & Co., Inc. | 210,464 | 949,000 | 0.36% | ||
| 27 | KENNEDY CAPITAL MANAGEMENT LLC | 198,576 | 896,000 | 0.34% | ||
| 28 | NORGES BANK | 190,476 | 859,000 | 0.33% | ||
| 29 | TEACHERS ADVISORS, LLC | 148,960 | 672,000 | 0.26% | ||
| 30 | WATER ISLAND CAPITAL LLC | 145,604 | 656,000 | 0.25% | ||
| 31 | NJ State Employees Deferred Compensation Plan | 130,000 | 646,000 | 0.25% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 135,300 | 611,000 | 0.23% | ||
| 33 | CORNERSTONE CAPITAL MANAGEMENT HOLDINGS LLC. | 128,100 | 577,000 | 0.22% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 124,439 | 561,000 | 0.22% | ||
| 35 | Swiss National Bank | 122,500 | 537,000 | 0.21% | ||
| 36 | BANK OF AMERICA CORP /DE/ | 112,500 | 507,000 | 0.19% | Put | |
| 37 | MORGAN STANLEY | 108,778 | 490,000 | 0.19% | ||
| 38 | VIRTUS ETF ADVISERS LLC | 101,554 | 458,000 | 0.18% | ||
| 39 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 99,367 | 448,000 | 0.17% | ||
| 40 | PRIMECAP MANAGEMENT CO/CA/ | 91,000 | 410,000 | 0.16% | ||
| 41 | BANK OF AMERICA CORP /DE/ | 90,000 | 406,000 | 0.16% | ||
| 42 | TFS CAPITAL LLC | 80,101 | 361,000 | 0.14% | ||
| 43 | NEXTHERA CAPITAL LP | 80,000 | 361,000 | 0.14% | ||
| 44 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 77,590 | 350,000 | 0.13% | ||
| 45 | Nationwide Fund Advisors | 74,792 | 337,000 | 0.13% | ||
| 46 | ALLIANCEBERNSTEIN L.P. | 69,853 | 315,000 | 0.12% | ||
| 47 | RHUMBLINE ADVISERS | 61,323 | 277,000 | 0.11% | ||
| 48 | CITIGROUP INC | 60,258 | 272,000 | 0.10% | ||
| 49 | WELLS FARGO & COMPANY/MN | 56,540 | 254,000 | 0.10% | ||
| 50 | ProShare Advisors LLC | 54,159 | 244,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
