| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 8,330,064 | 43,066,000 | 15.50% | ||
| 2 | ORBIMED ADVISORS LLC | 5,546,100 | 28,673,000 | 10.32% | ||
| 3 | Capital World Investors | 4,769,000 | 24,656,000 | 8.87% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,384,797 | 22,669,000 | 8.16% | ||
| 5 | BAKER BROS. ADVISORS LP | 4,034,112 | 20,856,000 | 7.50% | ||
| 6 | JPMORGAN CHASE & CO | 3,126,184 | 16,162,000 | 5.82% | ||
| 7 | FMR LLC | 2,686,007 | 13,886,000 | 5.00% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 2,532,477 | 13,093,000 | 4.71% | ||
| 9 | BlackRock Fund Advisors | 2,267,416 | 11,723,000 | 4.22% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 2,048,391 | 10,590,000 | 3.81% | ||
| 11 | VANGUARD GROUP INC | 1,590,880 | 8,225,000 | 2.96% | ||
| 12 | CLINTON GROUP INC | 1,194,048 | 6,173,000 | 2.22% | ||
| 13 | WALL STREET ASSOCIATES | 1,044,800 | 5,402,000 | 1.94% | ||
| 14 | D. E. Shaw & Co., Inc. | 906,380 | 4,686,000 | 1.69% | ||
| 15 | STATE STREET CORP | 886,521 | 4,584,000 | 1.65% | ||
| 16 | SENZAR ASSET MANAGEMENT, LLC | 787,600 | 4,071,000 | 1.46% | ||
| 17 | NORTHERN TRUST CORP | 670,682 | 3,467,000 | 1.25% | ||
| 18 | State of New Jersey Common Pension Fund A | 559,082 | 2,890,000 | 1.04% | ||
| 19 | Allianz Asset Management GmbH | 531,300 | 2,746,000 | 0.99% | ||
| 20 | JENNISON ASSOCIATES LLC | 492,365 | 2,546,000 | 0.92% | ||
| 21 | ALTRINSIC GLOBAL ADVISORS LLC | 476,645 | 2,464,000 | 0.89% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 294,491 | 1,522,000 | 0.55% | ||
| 23 | Bank of New York Mellon Corp | 263,880 | 1,364,000 | 0.49% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 253,179 | 1,309,000 | 0.47% | ||
| 25 | DEUTSCHE BANK AG\ | 242,408 | 1,252,000 | 0.45% | ||
| 26 | MASON STREET ADVISORS, LLC | 226,790 | 1,173,000 | 0.42% | ||
| 27 | DAFNA Capital Management LLC | 220,190 | 1,138,000 | 0.41% | ||
| 28 | BlackRock Investment Management, LLC | 182,940 | 946,000 | 0.34% | ||
| 29 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 178,000 | 920,000 | 0.33% | ||
| 30 | ROYAL BANK OF CANADA | 136,623 | 706,000 | 0.25% | ||
| 31 | NJ State Employees Deferred Compensation Plan | 130,000 | 672,000 | 0.24% | ||
| 32 | PRIMECAP MANAGEMENT CO/CA/ | 128,000 | 662,000 | 0.24% | ||
| 33 | COMMONWEALTH BANK OF AUSTRALIA | 127,900 | 661,000 | 0.24% | ||
| 34 | Nationwide Fund Advisors | 121,424 | 628,000 | 0.23% | ||
| 35 | BAILARD, INC. | 120,000 | 620,000 | 0.22% | ||
| 36 | CREDIT SUISSE AG/ | 119,412 | 618,000 | 0.22% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 117,200 | 606,000 | 0.22% | ||
| 38 | GOLDMAN SACHS GROUP INC | 110,780 | 573,000 | 0.21% | ||
| 39 | DIMENSIONAL FUND ADVISORS LP | 109,276 | 565,000 | 0.20% | ||
| 40 | ProShare Advisors LLC | 101,236 | 523,000 | 0.19% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 98,983 | 512,000 | 0.18% | ||
| 42 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 96,711 | 500,000 | 0.18% | ||
| 43 | TEACHERS ADVISORS, LLC | 83,364 | 431,000 | 0.16% | ||
| 44 | PRICE T ROWE ASSOCIATES INC /MD/ | 81,500 | 421,000 | 0.15% | ||
| 45 | Laurion Capital Management LP | 79,093 | 409,000 | 0.15% | ||
| 46 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 77,590 | 401,000 | 0.14% | ||
| 47 | Swiss National Bank | 73,100 | 378,000 | 0.14% | ||
| 48 | RHUMBLINE ADVISERS | 63,443 | 328,000 | 0.12% | ||
| 49 | OXFORD ASSET MANAGEMENT LLP | 61,986 | 320,000 | 0.12% | ||
| 50 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 61,300 | 317,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
