| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 8,709,302 | 46,856,000 | 15.52% | ||
| 2 | BAKER BROS. ADVISORS LP | 6,815,777 | 36,669,000 | 12.15% | ||
| 3 | ORBIMED ADVISORS LLC | 5,546,100 | 29,838,000 | 9.88% | ||
| 4 | Capital World Investors | 4,769,000 | 25,657,000 | 8.50% | ||
| 5 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,438,882 | 23,881,000 | 7.91% | ||
| 6 | JPMORGAN CHASE & CO | 2,904,415 | 15,626,000 | 5.18% | ||
| 7 | FMR LLC | 2,590,053 | 13,934,000 | 4.62% | ||
| 8 | BlackRock Fund Advisors | 2,135,473 | 11,489,000 | 3.81% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 2,080,602 | 11,194,000 | 3.71% | ||
| 10 | VANGUARD GROUP INC | 1,645,251 | 8,851,000 | 2.93% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 1,431,036 | 7,699,000 | 2.55% | ||
| 12 | SENZAR ASSET MANAGEMENT, LLC | 1,335,300 | 7,184,000 | 2.38% | ||
| 13 | CLINTON GROUP INC | 1,102,304 | 5,930,000 | 1.96% | ||
| 14 | STATE STREET CORP | 935,621 | 5,030,000 | 1.67% | ||
| 15 | D. E. Shaw & Co., Inc. | 733,654 | 3,947,000 | 1.31% | ||
| 16 | NORTHERN TRUST CORP | 607,270 | 3,268,000 | 1.08% | ||
| 17 | ALTRINSIC GLOBAL ADVISORS LLC | 576,645 | 3,102,000 | 1.03% | ||
| 18 | State of New Jersey Common Pension Fund D | 559,082 | 3,008,000 | 1.00% | ||
| 19 | Allianz Asset Management GmbH | 500,880 | 2,695,000 | 0.89% | ||
| 20 | EverPoint Asset Management, LLC | 490,000 | 2,636,000 | 0.87% | ||
| 21 | JENNISON ASSOCIATES LLC | 438,053 | 2,357,000 | 0.78% | ||
| 22 | ASCEND CAPITAL, LLC | 400,000 | 2,152,000 | 0.71% | ||
| 23 | ROYAL BANK OF CANADA | 326,920 | 1,758,000 | 0.58% | ||
| 24 | Bank of New York Mellon Corp | 310,893 | 1,673,000 | 0.55% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 303,972 | 1,635,000 | 0.54% | ||
| 26 | DEUTSCHE BANK AG\ | 300,949 | 1,618,000 | 0.54% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 299,729 | 1,613,000 | 0.53% | ||
| 28 | DAFNA Capital Management LLC | 240,190 | 1,292,000 | 0.43% | SH | |
| 29 | MASON STREET ADVISORS, LLC | 226,790 | 1,220,000 | 0.40% | ||
| 30 | GOLDMAN SACHS GROUP INC | 200,700 | 1,080,000 | 0.36% | Put | |
| 31 | GOLDMAN SACHS GROUP INC | 200,000 | 1,076,000 | 0.36% | Call | |
| 32 | BlackRock Investment Management, LLC | 190,862 | 1,027,000 | 0.34% | ||
| 33 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 178,000 | 958,000 | 0.32% | ||
| 34 | Rock Springs Capital Management LP | 146,000 | 785,000 | 0.26% | ||
| 35 | NJ State Employees Deferred Compensation Plan | 130,000 | 699,000 | 0.23% | ||
| 36 | Nationwide Fund Advisors | 124,694 | 671,000 | 0.22% | ||
| 37 | BAILARD, INC. | 120,000 | 646,000 | 0.21% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 117,200 | 631,000 | 0.21% | ||
| 39 | TFS CAPITAL LLC | 113,162 | 609,000 | 0.20% | ||
| 40 | COMMONWEALTH BANK OF AUSTRALIA | 109,770 | 591,000 | 0.20% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 106,789 | 575,000 | 0.19% | ||
| 42 | GOLDMAN SACHS GROUP INC | 106,498 | 573,000 | 0.19% | ||
| 43 | Swiss National Bank | 92,500 | 498,000 | 0.16% | ||
| 44 | PRIMECAP MANAGEMENT CO/CA/ | 91,000 | 490,000 | 0.16% | ||
| 45 | TEACHERS ADVISORS, LLC | 90,243 | 486,000 | 0.16% | ||
| 46 | NOMURA HOLDINGS INC | 78,859 | 426,000 | 0.14% | ||
| 47 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 77,590 | 417,000 | 0.14% | ||
| 48 | RHUMBLINE ADVISERS | 68,993 | 371,000 | 0.12% | ||
| 49 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 68,400 | 368,000 | 0.12% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 65,500 | 352,000 | 0.12% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
