| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,568,562 | 147,701,000 | 31.39% | ||
| 2 | PERCEPTIVE ADVISORS LLC | 1,186,630 | 38,363,000 | 8.15% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,163,811 | 37,626,000 | 8.00% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 1,000,502 | 32,346,000 | 6.87% | ||
| 5 | PFM Health Sciences, LP | 703,987 | 22,760,000 | 4.84% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 699,384 | 22,611,000 | 4.81% | ||
| 7 | VANGUARD GROUP INC | 503,659 | 16,284,000 | 3.46% | ||
| 8 | FORESITE CAPITAL MANAGEMENT III, LLC | 460,000 | 14,872,000 | 3.16% | ||
| 9 | RA CAPITAL MANAGEMENT, L.P. | 457,142 | 14,779,000 | 3.14% | ||
| 10 | BAKER BROS. ADVISORS LP | 400,000 | 12,932,000 | 2.75% | ||
| 11 | JENNISON ASSOCIATES LLC | 312,822 | 10,114,000 | 2.15% | ||
| 12 | GILDER GAGNON HOWE & CO LLC | 297,053 | 9,604,000 | 2.04% | ||
| 13 | Redmile Group, LLC | 218,718 | 7,071,000 | 1.50% | ||
| 14 | UBS Group AG | 215,431 | 6,965,000 | 1.48% | ||
| 15 | DRIEHAUS CAPITAL MANAGEMENT LLC | 201,262 | 6,507,000 | 1.38% | ||
| 16 | SABBY MANAGEMENT, LLC | 342,857 | 6,446,000 | 1.37% | ||
| 17 | JPMORGAN CHASE & CO | 187,500 | 6,062,000 | 1.29% | ||
| 18 | RTW INVESTMENTS, LP | 171,898 | 5,558,000 | 1.18% | ||
| 19 | BlackRock Fund Advisors | 171,121 | 5,532,000 | 1.18% | ||
| 20 | EVENTIDE ASSET MANAGEMENT, LLC | 165,000 | 5,334,000 | 1.13% | ||
| 21 | VHCP MANAGEMENT II, LLC | 141,611 | 4,578,000 | 0.97% | ||
| 22 | Iguana Healthcare Management, LLC | 110,000 | 3,556,000 | 0.76% | ||
| 23 | STATE STREET CORP | 88,108 | 2,846,000 | 0.60% | ||
| 24 | BlackRock Institutional Trust Company, N.A. | 77,074 | 2,492,000 | 0.53% | ||
| 25 | Asset Management One Co., Ltd. | 75,575 | 2,465,000 | 0.52% | ||
| 26 | NORTHERN TRUST CORP | 75,771 | 2,450,000 | 0.52% | ||
| 27 | Rock Springs Capital Management LP | 70,500 | 2,279,000 | 0.48% | ||
| 28 | CASDIN CAPITAL, LLC | 65,000 | 2,101,000 | 0.45% | ||
| 29 | VHCP Management, LLC | 60,691 | 1,962,000 | 0.42% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 52,099 | 1,684,000 | 0.36% | ||
| 31 | Spark Investment Management LLC | 44,100 | 1,425,000 | 0.30% | ||
| 32 | MOORE CAPITAL MANAGEMENT, LP | 40,000 | 1,293,000 | 0.27% | ||
| 33 | ALLIANCEBERNSTEIN L.P. | 26,416 | 1,114,000 | 0.24% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 31,415 | 1,016,000 | 0.22% | ||
| 35 | Bank of New York Mellon Corp | 29,955 | 969,000 | 0.21% | ||
| 36 | JANE STREET GROUP, LLC | 25,679 | 830,000 | 0.18% | ||
| 37 | GOLDMAN SACHS GROUP INC | 24,720 | 799,000 | 0.17% | ||
| 38 | BlackRock Investment Management, LLC | 23,373 | 756,000 | 0.16% | ||
| 39 | SOROS FUND MANAGEMENT LLC | 21,000 | 679,000 | 0.14% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 19,346 | 626,000 | 0.13% | ||
| 41 | FRED ALGER MANAGEMENT, LLC | 16,050 | 519,000 | 0.11% | ||
| 42 | Partner Investment Management, L.P. | 15,634 | 505,000 | 0.11% | ||
| 43 | A.R.T. Advisors, LLC | 14,800 | 478,000 | 0.10% | ||
| 44 | Nationwide Fund Advisors | 14,022 | 453,000 | 0.10% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,745 | 412,000 | 0.09% | ||
| 46 | TEACHERS ADVISORS, LLC | 10,025 | 324,000 | 0.07% | ||
| 47 | Swiss National Bank | 9,600 | 310,000 | 0.07% | ||
| 48 | DEUTSCHE BANK AG\ | 9,316 | 300,000 | 0.06% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 7,200 | 233,000 | 0.05% | ||
| 50 | METROPOLITAN LIFE INSURANCE CO/NY | 7,158 | 231,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
