| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADVISOR GROUP, INC. | 25 | 0 | 0.00% | ||
| 2 | Tower Research Capital LLC (TRC) | 323 | 4,000 | 0.01% | ||
| 3 | MORGAN STANLEY | 368 | 5,000 | 0.01% | ||
| 4 | DAFNA Capital Management LLC | 458 | 6,000 | 0.01% | ||
| 5 | TURNER INVESTMENTS LLC | 1,000 | 13,000 | 0.02% | ||
| 6 | SABBY MANAGEMENT, LLC | 17,428 | 235,000 | 0.42% | ||
| 7 | DEUTSCHE BANK AG\ | 23,387 | 315,000 | 0.56% | ||
| 8 | UBS Group AG | 25,573 | 345,000 | 0.62% | ||
| 9 | ACUTA CAPITAL PARTNERS, LLC | 33,077 | 446,000 | 0.80% | ||
| 10 | Ghost Tree Capital, LLC | 46,622 | 629,000 | 1.12% | ||
| 11 | EcoR1 Capital, LLC | 63,468 | 856,000 | 1.53% | ||
| 12 | BOXER CAPITAL, LLC | 139,899 | 1,887,000 | 3.37% | ||
| 13 | VHCP Management, LLC | 158,352 | 2,136,000 | 3.81% | ||
| 14 | FORESITE CAPITAL MANAGEMENT III, LLC | 197,072 | 2,659,000 | 4.75% | ||
| 15 | QVT Financial LP | 263,921 | 2,906,000 | 5.19% | ||
| 16 | RA CAPITAL MANAGEMENT, L.P. | 234,240 | 3,160,000 | 5.64% | ||
| 17 | VHCP MANAGEMENT II, LLC | 369,490 | 4,984,000 | 8.89% | ||
| 18 | NEA Management Company, LLC | 452,167 | 6,100,000 | 10.89% | ||
| 19 | BAKER BROS. ADVISORS LP | 496,901 | 6,703,000 | 11.96% | ||
| 20 | VIVO CAPITAL, LLC | 527,842 | 7,121,000 | 12.71% | ||
| 21 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,150,700 | 15,523,000 | 27.70% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
