| 1 |
RA CAPITAL MANAGEMENT, L.P. |
1,832,911 |
11,071,000 |
12.37% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
1,760,600 |
10,634,000 |
11.88% |
|
|
| 3 |
BAKER BROS. ADVISORS LP |
1,639,871 |
9,905,000 |
11.06% |
|
|
| 4 |
Broadfin Capital, LLC |
1,557,106 |
9,405,000 |
10.50% |
|
|
| 5 |
VHCP Management, LLC |
1,500,000 |
9,060,000 |
10.12% |
|
|
| 6 |
GREAT POINT PARTNERS LLC |
1,205,183 |
7,279,000 |
8.13% |
|
|
| 7 |
Knoll Capital Management, LLC |
1,115,315 |
6,737,000 |
7.52% |
|
|
| 8 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
997,349 |
6,024,000 |
6.73% |
|
|
| 9 |
Ghost Tree Capital, LLC |
688,961 |
4,161,000 |
4.65% |
|
|
| 10 |
HAYMAN CAPITAL MANAGEMENT, L.P. |
625,792 |
3,780,000 |
4.22% |
|
|
| 11 |
Alyeska Investment Group, L.P. |
555,375 |
3,354,000 |
3.75% |
|
|
| 12 |
Palo Alto Investors LP |
254,188 |
1,535,000 |
1.71% |
|
|
| 13 |
BALYASNY ASSET MANAGEMENT L.P. |
219,976 |
1,329,000 |
1.48% |
|
|
| 14 |
FRED ALGER MANAGEMENT, LLC |
164,950 |
996,000 |
1.11% |
|
|
| 15 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
96,799 |
585,000 |
0.65% |
|
|
| 16 |
A.R.T. Advisors, LLC |
81,568 |
492,000 |
0.55% |
|
|
| 17 |
Spark Investment Management LLC |
80,330 |
485,000 |
0.54% |
|
|
| 18 |
DEUTSCHE BANK AG\ |
64,469 |
389,000 |
0.43% |
|
|
| 19 |
Quantitative Systematic Strategies LLC |
63,619 |
384,000 |
0.43% |
|
|
| 20 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
53,900 |
326,000 |
0.36% |
Put |
|
| 21 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
51,000 |
308,000 |
0.34% |
|
|
| 22 |
MORGAN STANLEY |
42,706 |
258,000 |
0.29% |
|
|
| 23 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
37,000 |
223,000 |
0.25% |
Call |
|
| 24 |
D. E. Shaw & Co., Inc. |
30,526 |
184,000 |
0.21% |
|
|
| 25 |
STIFEL FINANCIAL CORP |
26,900 |
162,000 |
0.18% |
|
|
| 26 |
MILLENNIUM MANAGEMENT LLC |
23,476 |
142,000 |
0.16% |
|
|
| 27 |
GROUP ONE TRADING LLC |
18,076 |
109,000 |
0.12% |
|
|
| 28 |
Rotella Capital Management, Inc. |
14,828 |
90,000 |
0.10% |
|
|
| 29 |
PANAGORA ASSET MANAGEMENT INC |
11,728 |
71,000 |
0.08% |
|
|
| 30 |
BARCLAYS PLC |
5,700 |
34,000 |
0.04% |
|
|
| 31 |
MSI Financial Services Inc |
800 |
5,000 |
0.01% |
|
|
| 32 |
Tower Research Capital LLC (TRC) |
775 |
5,000 |
0.01% |
|
|
| 33 |
DEUTSCHE BANK AG\ |
500 |
3,000 |
0.00% |
Call |
|
| 34 |
BANK OF AMERICA CORP /DE/ |
400 |
2,000 |
0.00% |
|
|
| 35 |
UBS Group AG |
400 |
2,000 |
0.00% |
|
|
| 36 |
WELLS FARGO & COMPANY/MN |
250 |
2,000 |
0.00% |
|
|
| 37 |
NEXT Financial Group, Inc |
100 |
0 |
0.00% |
|
|
| 38 |
CITIGROUP INC |
38 |
0 |
0.00% |
|
|
