| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 3,652,931 | 13,845,000 | 17.42% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 3,032,911 | 11,495,000 | 14.46% | ||
| 3 | BAKER BROS. ADVISORS LP | 2,336,359 | 8,855,000 | 11.14% | ||
| 4 | GREAT POINT PARTNERS LLC | 2,020,166 | 7,656,000 | 9.63% | ||
| 5 | Broadfin Capital, LLC | 1,557,106 | 5,901,000 | 7.42% | ||
| 6 | VHCP MANAGEMENT II, LLC | 1,130,500 | 4,285,000 | 5.39% | ||
| 7 | Knoll Capital Management, LLC | 1,115,315 | 4,227,000 | 5.32% | ||
| 8 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,069,914 | 4,055,000 | 5.10% | ||
| 9 | Alyeska Investment Group, L.P. | 1,049,114 | 3,976,000 | 5.00% | ||
| 10 | PERCEPTIVE ADVISORS LLC | 1,028,272 | 3,897,000 | 4.90% | ||
| 11 | VHCP Management, LLC | 484,500 | 1,836,000 | 2.31% | ||
| 12 | BlackRock Fund Advisors | 354,614 | 1,344,000 | 1.69% | ||
| 13 | Ghost Tree Capital, LLC | 300,000 | 1,137,000 | 1.43% | ||
| 14 | BALYASNY ASSET MANAGEMENT L.P. | 295,982 | 1,122,000 | 1.41% | ||
| 15 | Palo Alto Investors LP | 254,188 | 963,000 | 1.21% | ||
| 16 | SABBY MANAGEMENT, LLC | 200,868 | 761,000 | 0.96% | ||
| 17 | GROUP ONE TRADING LLC | 199,031 | 754,000 | 0.95% | ||
| 18 | D. E. Shaw & Co., Inc. | 120,587 | 457,000 | 0.57% | ||
| 19 | DEUTSCHE BANK AG\ | 96,577 | 365,000 | 0.46% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 69,300 | 263,000 | 0.33% | Put | |
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 67,231 | 255,000 | 0.32% | ||
| 22 | FRED ALGER MANAGEMENT, LLC | 62,700 | 238,000 | 0.30% | ||
| 23 | CREDIT SUISSE AG/ | 59,447 | 225,000 | 0.28% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 54,600 | 207,000 | 0.26% | Call | |
| 25 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 51,000 | 193,000 | 0.24% | ||
| 26 | STIFEL FINANCIAL CORP | 46,200 | 175,000 | 0.22% | ||
| 27 | A.R.T. Advisors, LLC | 28,468 | 107,000 | 0.13% | ||
| 28 | Virtu KCG Holdings LLC | 24,728 | 94,000 | 0.12% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 22,829 | 87,000 | 0.11% | ||
| 30 | CUTLER GROUP LLC / CA | 22,591 | 85,000 | 0.11% | ||
| 31 | MORGAN STANLEY | 22,361 | 85,000 | 0.11% | ||
| 32 | ProShare Advisors LLC | 20,102 | 76,000 | 0.10% | ||
| 33 | PIPER SANDLER & CO. | 11,641 | 73,000 | 0.09% | ||
| 34 | SIMPLEX TRADING, LLC | 18,922 | 71,000 | 0.09% | ||
| 35 | GOLDMAN SACHS GROUP INC | 16,357 | 62,000 | 0.08% | ||
| 36 | PDT Partners, LLC | 15,400 | 58,000 | 0.07% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 14,567 | 55,000 | 0.07% | ||
| 38 | DekaBank Deutsche Girozentrale | 13,500 | 49,000 | 0.06% | ||
| 39 | Spot Trading L.L.C | 11,900 | 45,000 | 0.06% | Call | |
| 40 | CITIGROUP INC | 3,452 | 13,000 | 0.02% | ||
| 41 | PENSERRA CAPITAL MANAGEMENT LLC | 3,325 | 12,000 | 0.02% | ||
| 42 | JPMORGAN CHASE & CO | 2,703 | 10,000 | 0.01% | ||
| 43 | Spot Trading L.L.C | 2,000 | 8,000 | 0.01% | Put | |
| 44 | UBS Group AG | 2,063 | 8,000 | 0.01% | ||
| 45 | CUTLER GROUP LLC / CA | 1,300 | 4,000 | 0.01% | Put | |
| 46 | MSI Financial Services Inc | 840 | 3,000 | 0.00% | ||
| 47 | BANK OF AMERICA CORP /DE/ | 400 | 2,000 | 0.00% | ||
| 48 | WELLS FARGO & COMPANY/MN | 250 | 1,000 | 0.00% | ||
| 49 | BARCLAYS PLC | 253 | 0 | 0.00% | ||
| 50 | CUTLER GROUP LLC / CA | 400 | 0 | 0.00% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
