| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 3,968,435 | 9,802,000 | 22.15% | ||
| 2 | BAKER BROS. ADVISORS LP | 2,336,359 | 5,771,000 | 13.04% | ||
| 3 | Broadfin Capital, LLC | 2,047,449 | 5,057,000 | 11.43% | ||
| 4 | RA CAPITAL MANAGEMENT, L.P. | 2,044,756 | 5,051,000 | 11.41% | ||
| 5 | VHCP MANAGEMENT II, LLC | 1,537,463 | 3,798,000 | 8.58% | ||
| 6 | Knoll Capital Management, LLC | 1,115,315 | 2,799,000 | 6.32% | ||
| 7 | Alyeska Investment Group, L.P. | 1,059,077 | 2,616,000 | 5.91% | ||
| 8 | VHCP Management, LLC | 658,910 | 1,628,000 | 3.68% | ||
| 9 | Ghost Tree Capital, LLC | 650,000 | 1,606,000 | 3.63% | ||
| 10 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 396,800 | 980,000 | 2.21% | ||
| 11 | BlackRock Fund Advisors | 386,365 | 954,000 | 2.16% | ||
| 12 | Palo Alto Investors LP | 272,788 | 674,000 | 1.52% | ||
| 13 | Jefferies Group LLC | 156,400 | 386,000 | 0.87% | Call | |
| 14 | ROYCE & ASSOCIATES LP | 138,055 | 341,000 | 0.77% | ||
| 15 | GROUP ONE TRADING LLC | 107,829 | 266,000 | 0.60% | ||
| 16 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 88,995 | 220,000 | 0.50% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 87,700 | 217,000 | 0.49% | Put | |
| 18 | CREDIT SUISSE AG/ | 83,795 | 207,000 | 0.47% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 76,500 | 189,000 | 0.43% | Call | |
| 20 | MILLENNIUM MANAGEMENT LLC | 74,200 | 183,000 | 0.41% | ||
| 21 | CUTLER GROUP LLC / CA | 38,900 | 174,000 | 0.39% | Put | |
| 22 | WOLVERINE TRADING LP /BD | 53,600 | 135,000 | 0.31% | Call | |
| 23 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 51,000 | 126,000 | 0.28% | ||
| 24 | Virtu KCG Holdings LLC | 47,441 | 117,000 | 0.26% | ||
| 25 | STIFEL FINANCIAL CORP | 42,900 | 105,000 | 0.24% | ||
| 26 | DEUTSCHE BANK AG\ | 39,869 | 97,000 | 0.22% | ||
| 27 | WOLVERINE TRADING LP /BD | 36,200 | 91,000 | 0.21% | Put | |
| 28 | D. E. Shaw & Co., Inc. | 32,579 | 80,000 | 0.18% | ||
| 29 | Leisure Capital Management | 23,863 | 59,000 | 0.13% | ||
| 30 | CUTLER GROUP LLC / CA | 24,130 | 59,000 | 0.13% | ||
| 31 | GOLDMAN SACHS GROUP INC | 22,667 | 56,000 | 0.13% | ||
| 32 | MORGAN STANLEY | 19,391 | 48,000 | 0.11% | ||
| 33 | ProShare Advisors LLC | 17,384 | 43,000 | 0.10% | ||
| 34 | SABBY MANAGEMENT, LLC | 17,058 | 42,000 | 0.09% | ||
| 35 | Formidable Asset Management, LLC | 16,085 | 40,000 | 0.09% | ||
| 36 | CITADEL ADVISORS LLC | 14,593 | 36,000 | 0.08% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 14,674 | 36,000 | 0.08% | ||
| 38 | Spot Trading L.L.C | 14,000 | 35,000 | 0.08% | Call | |
| 39 | CITADEL ADVISORS LLC | 12,100 | 30,000 | 0.07% | Call | |
| 40 | Jefferies Group LLC | 10,500 | 26,000 | 0.06% | ||
| 41 | CUTLER GROUP LLC / CA | 108,000 | 17,000 | 0.04% | Call | |
| 42 | UBS Group AG | 6,959 | 17,000 | 0.04% | ||
| 43 | SIMPLEX TRADING, LLC | 5,463 | 13,000 | 0.03% | ||
| 44 | CITIGROUP INC | 4,445 | 11,000 | 0.02% | ||
| 45 | PENSERRA CAPITAL MANAGEMENT LLC | 4,416 | 10,000 | 0.02% | ||
| 46 | BARCLAYS PLC | 1,352 | 3,000 | 0.01% | ||
| 47 | FT OPTIONS LLC | 20,000 | 3,000 | 0.01% | Call | |
| 48 | MSI Financial Services Inc | 840 | 2,000 | 0.00% | ||
| 49 | BANK OF AMERICA CORP /DE/ | 491 | 1,000 | 0.00% | ||
| 50 | WELLS FARGO & COMPANY/MN | 500 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
