| 1 |
BAKER BROS. ADVISORS LP |
1,789,871 |
11,706,000 |
13.89% |
|
|
| 2 |
Broadfin Capital, LLC |
1,579,806 |
10,332,000 |
12.26% |
|
|
| 3 |
RA CAPITAL MANAGEMENT, L.P. |
1,525,894 |
9,979,000 |
11.84% |
|
|
| 4 |
VHCP Management, LLC |
1,500,000 |
9,810,000 |
11.64% |
|
|
| 5 |
FRANKLIN RESOURCES INC |
1,457,100 |
9,529,000 |
11.30% |
|
|
| 6 |
GREAT POINT PARTNERS LLC |
1,189,086 |
7,777,000 |
9.22% |
|
|
| 7 |
Knoll Capital Management, LLC |
1,115,315 |
7,294,000 |
8.65% |
|
|
| 8 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,088,449 |
7,118,000 |
8.44% |
|
|
| 9 |
Ghost Tree Capital, LLC |
600,000 |
3,924,000 |
4.65% |
|
|
| 10 |
BALYASNY ASSET MANAGEMENT L.P. |
188,973 |
1,236,000 |
1.47% |
|
|
| 11 |
Palo Alto Investors LP |
156,588 |
1,024,000 |
1.21% |
|
|
| 12 |
FRED ALGER MANAGEMENT, LLC |
116,200 |
760,000 |
0.90% |
|
|
| 13 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
103,667 |
678,000 |
0.80% |
|
|
| 14 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
88,800 |
581,000 |
0.69% |
Call |
|
| 15 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
80,700 |
528,000 |
0.63% |
Put |
|
| 16 |
DEUTSCHE BANK AG\ |
65,772 |
430,000 |
0.51% |
|
|
| 17 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
51,000 |
334,000 |
0.40% |
|
|
| 18 |
MORGAN STANLEY |
43,033 |
282,000 |
0.33% |
|
|
| 19 |
STIFEL FINANCIAL CORP |
26,300 |
172,000 |
0.20% |
|
|
| 20 |
GROUP ONE TRADING LLC |
24,220 |
158,000 |
0.19% |
|
|
| 21 |
Spark Investment Management LLC |
24,100 |
156,000 |
0.19% |
|
|
| 22 |
Virtu KCG Holdings LLC |
22,939 |
150,000 |
0.18% |
|
|
| 23 |
Parallax Volatility Advisers, L.P. |
18,900 |
124,000 |
0.15% |
Call |
|
| 24 |
D. E. Shaw & Co., Inc. |
11,554 |
76,000 |
0.09% |
|
|
| 25 |
UBS Group AG |
7,910 |
52,000 |
0.06% |
|
|
| 26 |
SIMPLEX TRADING, LLC |
5,726 |
37,000 |
0.04% |
|
|
| 27 |
Parallax Volatility Advisers, L.P. |
4,500 |
30,000 |
0.04% |
Put |
|
| 28 |
CITADEL ADVISORS LLC |
1,041 |
7,000 |
0.01% |
|
|
| 29 |
Winslow, Evans & Crocker, Inc. |
1,000 |
6,540 |
0.01% |
|
|
| 30 |
CITIGROUP INC |
847 |
6,000 |
0.01% |
|
|
| 31 |
Tower Research Capital LLC (TRC) |
647 |
4,000 |
0.00% |
|
|
| 32 |
BANK OF AMERICA CORP /DE/ |
400 |
3,000 |
0.00% |
|
|
| 33 |
WELLS FARGO & COMPANY/MN |
250 |
2,000 |
0.00% |
|
|
| 34 |
AMERICAN INTERNATIONAL GROUP, INC. |
150 |
981 |
0.00% |
|
|
| 35 |
NEXT Financial Group, Inc |
100 |
0 |
0.00% |
|
|
