| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 3,032,911 | 19,047,000 | 14.53% | ||
| 2 | FRANKLIN RESOURCES INC | 2,848,581 | 17,889,000 | 13.65% | ||
| 3 | BAKER BROS. ADVISORS LP | 2,336,359 | 14,672,000 | 11.19% | ||
| 4 | GREAT POINT PARTNERS LLC | 2,012,622 | 12,639,000 | 9.64% | ||
| 5 | Broadfin Capital, LLC | 1,557,106 | 9,779,000 | 7.46% | ||
| 6 | VHCP MANAGEMENT II, LLC | 1,130,500 | 7,100,000 | 5.42% | ||
| 7 | Knoll Capital Management, LLC | 1,115,315 | 7,004,000 | 5.34% | ||
| 8 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,069,914 | 6,719,000 | 5.13% | ||
| 9 | PERCEPTIVE ADVISORS LLC | 1,028,272 | 6,458,000 | 4.93% | ||
| 10 | Alyeska Investment Group, L.P. | 1,000,461 | 6,283,000 | 4.79% | ||
| 11 | BALYASNY ASSET MANAGEMENT L.P. | 735,306 | 4,618,000 | 3.52% | ||
| 12 | Ghost Tree Capital, LLC | 500,000 | 3,140,000 | 2.40% | ||
| 13 | VHCP Management, LLC | 484,500 | 3,043,000 | 2.32% | ||
| 14 | BlackRock Fund Advisors | 318,396 | 2,000,000 | 1.53% | ||
| 15 | Palo Alto Investors LP | 254,188 | 1,596,000 | 1.22% | ||
| 16 | GROUP ONE TRADING LLC | 234,658 | 1,474,000 | 1.12% | ||
| 17 | FRED ALGER MANAGEMENT, LLC | 175,700 | 1,103,000 | 0.84% | ||
| 18 | SABBY MANAGEMENT, LLC | 167,500 | 1,052,000 | 0.80% | ||
| 19 | DEUTSCHE BANK AG\ | 115,120 | 722,000 | 0.55% | ||
| 20 | D. E. Shaw & Co., Inc. | 100,073 | 628,000 | 0.48% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 89,700 | 563,000 | 0.43% | Put | |
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 82,779 | 520,000 | 0.40% | ||
| 23 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 51,000 | 320,000 | 0.24% | ||
| 24 | STIFEL FINANCIAL CORP | 49,200 | 309,000 | 0.24% | ||
| 25 | A.R.T. Advisors, LLC | 45,768 | 287,000 | 0.22% | ||
| 26 | CREDIT SUISSE AG/ | 43,740 | 275,000 | 0.21% | ||
| 27 | Quantitative Systematic Strategies LLC | 35,027 | 211,000 | 0.16% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 28,800 | 181,000 | 0.14% | Call | |
| 29 | MORGAN STANLEY | 27,581 | 173,000 | 0.13% | ||
| 30 | Spark Investment Management LLC | 26,400 | 165,000 | 0.13% | ||
| 31 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 25,000 | 157,000 | 0.12% | ||
| 32 | ProShare Advisors LLC | 22,001 | 138,000 | 0.11% | ||
| 33 | CUTLER GROUP LLC / CA | 20,291 | 127,000 | 0.10% | ||
| 34 | PDT Partners, LLC | 15,400 | 97,000 | 0.07% | ||
| 35 | SIMPLEX TRADING, LLC | 11,870 | 74,000 | 0.06% | ||
| 36 | PIPER SANDLER & CO. | 11,641 | 73,000 | 0.06% | ||
| 37 | Dynamic Technology Lab Private Ltd | 10,929 | 69,000 | 0.05% | ||
| 38 | Airain ltd | 10,728 | 67,000 | 0.05% | ||
| 39 | Spot Trading L.L.C | 10,000 | 63,000 | 0.05% | Call | |
| 40 | GOLDMAN SACHS GROUP INC | 10,093 | 63,000 | 0.05% | ||
| 41 | BANK OF AMERICA CORP /DE/ | 4,960 | 31,000 | 0.02% | ||
| 42 | CITADEL ADVISORS LLC | 4,730 | 30,000 | 0.02% | ||
| 43 | CITIGROUP INC | 3,740 | 23,000 | 0.02% | ||
| 44 | UBS Group AG | 2,957 | 19,000 | 0.01% | ||
| 45 | PENSERRA CAPITAL MANAGEMENT LLC | 2,217 | 14,000 | 0.01% | ||
| 46 | Spot Trading L.L.C | 2,000 | 13,000 | 0.01% | Put | |
| 47 | IFP ADVISORS, INC | 1,500 | 9,000 | 0.01% | ||
| 48 | MSI Financial Services Inc | 840 | 5,000 | 0.00% | ||
| 49 | Lenox Wealth Advisors, LLC | 600 | 4,000 | 0.00% | ||
| 50 | CUTLER GROUP LLC / CA | 3,700 | 4,000 | 0.00% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
