| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 3,652,931 | 16,402,000 | 17.76% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 3,032,911 | 13,618,000 | 14.74% | ||
| 3 | BAKER BROS. ADVISORS LP | 2,336,359 | 10,490,000 | 11.36% | ||
| 4 | Broadfin Capital, LLC | 1,557,106 | 6,991,000 | 7.57% | ||
| 5 | VHCP MANAGEMENT II, LLC | 1,454,402 | 6,530,000 | 7.07% | ||
| 6 | GREAT POINT PARTNERS LLC | 1,414,573 | 6,351,000 | 6.88% | ||
| 7 | Knoll Capital Management, LLC | 1,115,315 | 5,008,000 | 5.42% | ||
| 8 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,069,914 | 4,804,000 | 5.20% | ||
| 9 | Alyeska Investment Group, L.P. | 1,030,223 | 4,626,000 | 5.01% | ||
| 10 | PERCEPTIVE ADVISORS LLC | 1,028,272 | 4,617,000 | 5.00% | ||
| 11 | VHCP Management, LLC | 623,313 | 2,799,000 | 3.03% | ||
| 12 | BlackRock Fund Advisors | 361,130 | 1,621,000 | 1.75% | ||
| 13 | Ghost Tree Capital, LLC | 300,000 | 1,347,000 | 1.46% | ||
| 14 | Palo Alto Investors LP | 272,788 | 1,225,000 | 1.33% | ||
| 15 | GROUP ONE TRADING LLC | 206,128 | 926,000 | 1.00% | ||
| 16 | D. E. Shaw & Co., Inc. | 127,211 | 571,000 | 0.62% | ||
| 17 | Jefferies Group LLC | 118,800 | 533,000 | 0.58% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 103,100 | 463,000 | 0.50% | Call | |
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 84,083 | 378,000 | 0.41% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 78,100 | 351,000 | 0.38% | Put | |
| 21 | STIFEL FINANCIAL CORP | 62,000 | 278,000 | 0.30% | ||
| 22 | CREDIT SUISSE AG/ | 60,078 | 270,000 | 0.29% | ||
| 23 | FRED ALGER MANAGEMENT, LLC | 52,700 | 237,000 | 0.26% | ||
| 24 | WOLVERINE TRADING LP /BD | 541 | 234,794 | 0.25% | Call | |
| 25 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 51,000 | 229,000 | 0.25% | ||
| 26 | DEUTSCHE BANK AG\ | 43,794 | 195,000 | 0.21% | ||
| 27 | WOLVERINE TRADING LP /BD | 442 | 191,828 | 0.21% | Put | |
| 28 | GOLDMAN SACHS GROUP INC | 29,482 | 132,000 | 0.14% | ||
| 29 | CUTLER GROUP LLC / CA | 25,991 | 116,000 | 0.13% | ||
| 30 | Leisure Capital Management | 24,095 | 108,000 | 0.12% | ||
| 31 | A.R.T. Advisors, LLC | 23,538 | 105,000 | 0.11% | ||
| 32 | MORGAN STANLEY | 21,295 | 96,000 | 0.10% | ||
| 33 | ProShare Advisors LLC | 20,517 | 92,000 | 0.10% | ||
| 34 | SABBY MANAGEMENT, LLC | 18,317 | 82,000 | 0.09% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 14,567 | 65,000 | 0.07% | ||
| 36 | Formidable Asset Management, LLC | 14,485 | 61,000 | 0.07% | ||
| 37 | SIMPLEX TRADING, LLC | 13,147 | 59,000 | 0.06% | ||
| 38 | Spot Trading L.L.C | 10,000 | 45,000 | 0.05% | Call | |
| 39 | ACADIAN ASSET MANAGEMENT LLC | 8,536 | 38,000 | 0.04% | ||
| 40 | UBS Group AG | 6,746 | 30,000 | 0.03% | ||
| 41 | PENSERRA CAPITAL MANAGEMENT LLC | 3,312 | 15,000 | 0.02% | ||
| 42 | CITIGROUP INC | 3,287 | 15,000 | 0.02% | ||
| 43 | BANK OF AMERICA CORP /DE/ | 3,109 | 14,000 | 0.02% | ||
| 44 | D.A. DAVIDSON & CO. | 1,000 | 4,000 | 0.00% | ||
| 45 | MSI Financial Services Inc | 840 | 4,000 | 0.00% | ||
| 46 | BARCLAYS PLC | 383 | 2,000 | 0.00% | ||
| 47 | WELLS FARGO & COMPANY/MN | 500 | 2,000 | 0.00% | ||
| 48 | WOLVERINE TRADING LP /BD | 231 | 1,003 | 0.00% | ||
| 49 | PRELUDE CAPITAL MANAGEMENT, LLC | 200 | 1,000 | 0.00% | ||
| 50 | CUTLER GROUP LLC / CA | 400 | 0 | 0.00% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
