| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 4,477,500 | 9,403,000 | 27.04% | ||
| 2 | BAKER BROS. ADVISORS LP | 2,336,359 | 4,906,000 | 14.11% | ||
| 3 | Broadfin Capital, LLC | 2,057,106 | 4,320,000 | 12.42% | ||
| 4 | VHCP MANAGEMENT II, LLC | 1,537,463 | 3,229,000 | 9.28% | ||
| 5 | Knoll Capital Management, LLC | 1,205,498 | 2,532,000 | 7.28% | ||
| 6 | Alyeska Investment Group, L.P. | 814,514 | 1,710,000 | 4.92% | ||
| 7 | VHCP Management, LLC | 658,910 | 1,384,000 | 3.98% | ||
| 8 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 650,000 | 1,365,000 | 3.93% | ||
| 9 | ROYCE & ASSOCIATES LP | 645,055 | 1,355,000 | 3.90% | ||
| 10 | Ghost Tree Capital, LLC | 500,000 | 1,050,000 | 3.02% | ||
| 11 | Palo Alto Investors LP | 272,788 | 573,000 | 1.65% | ||
| 12 | J. Goldman & Co LP | 260,000 | 546,000 | 1.57% | ||
| 13 | Anson Funds Management LP | 142,973 | 300,000 | 0.86% | ||
| 14 | SABBY MANAGEMENT, LLC | 91,858 | 193,000 | 0.55% | ||
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 75,200 | 158,000 | 0.45% | Put | |
| 16 | Jefferies Group LLC | 73,700 | 155,000 | 0.45% | Call | |
| 17 | CUTLER GROUP LLC / CA | 28,900 | 150,000 | 0.43% | Put | |
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 60,692 | 127,000 | 0.37% | ||
| 19 | GOLDMAN SACHS GROUP INC | 59,233 | 124,000 | 0.36% | ||
| 20 | D. E. Shaw & Co., Inc. | 54,263 | 114,000 | 0.33% | ||
| 21 | GROUP ONE TRADING LLC | 51,258 | 108,000 | 0.31% | ||
| 22 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 51,000 | 107,000 | 0.31% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 43,550 | 91,000 | 0.26% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 40,100 | 84,000 | 0.24% | Call | |
| 25 | Squarepoint Ops LLC | 39,600 | 83,000 | 0.24% | ||
| 26 | Virtu KCG Holdings LLC | 35,205 | 74,000 | 0.21% | ||
| 27 | DEUTSCHE BANK AG\ | 33,190 | 69,000 | 0.20% | ||
| 28 | STIFEL FINANCIAL CORP | 27,500 | 58,000 | 0.17% | ||
| 29 | Leisure Capital Management | 24,325 | 51,000 | 0.15% | ||
| 30 | TFS CAPITAL LLC | 20,440 | 43,000 | 0.12% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 15,102 | 31,000 | 0.09% | ||
| 32 | CITADEL ADVISORS LLC | 14,500 | 30,000 | 0.09% | Put | |
| 33 | MORGAN STANLEY | 14,033 | 29,000 | 0.08% | ||
| 34 | Spot Trading L.L.C | 14,000 | 29,000 | 0.08% | Call | |
| 35 | CREDIT SUISSE AG/ | 13,801 | 29,000 | 0.08% | ||
| 36 | CUTLER GROUP LLC / CA | 14,049 | 29,000 | 0.08% | ||
| 37 | Formidable Asset Management, LLC | 13,785 | 29,000 | 0.08% | ||
| 38 | CITADEL ADVISORS LLC | 13,100 | 28,000 | 0.08% | Call | |
| 39 | Jefferies Group LLC | 10,500 | 22,000 | 0.06% | ||
| 40 | PENSERRA CAPITAL MANAGEMENT LLC | 7,764 | 16,000 | 0.05% | ||
| 41 | SIMPLEX TRADING, LLC | 6,277 | 13,000 | 0.04% | ||
| 42 | BARCLAYS PLC | 3,968 | 8,000 | 0.02% | ||
| 43 | HAP Trading, LLC | 16,300 | 7,000 | 0.02% | Call | |
| 44 | ACROSPIRE INVESTMENT MANAGEMENT LLC | 2,472 | 5,000 | 0.01% | ||
| 45 | BANK OF AMERICA CORP /DE/ | 1,808 | 4,000 | 0.01% | ||
| 46 | MSI Financial Services Inc | 840 | 2,000 | 0.01% | ||
| 47 | CUTLER GROUP LLC / CA | 15,700 | 2,000 | 0.01% | Call | |
| 48 | WELLS FARGO & COMPANY/MN | 500 | 1,000 | 0.00% | ||
| 49 | Tower Research Capital LLC (TRC) | 646 | 1,000 | 0.00% | ||
| 50 | NEXT Financial Group, Inc | 100 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
