| 1 |
BAKER BROS. ADVISORS LP |
1,789,871 |
10,077,000 |
17.67% |
|
|
| 2 |
Broadfin Capital, LLC |
1,556,016 |
8,760,000 |
15.36% |
|
|
| 3 |
VHCP Management, LLC |
1,500,000 |
8,446,000 |
14.81% |
|
|
| 4 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,413,208 |
7,956,000 |
13.95% |
|
|
| 5 |
Knoll Capital Management, LLC |
1,115,315 |
6,279,000 |
11.01% |
|
|
| 6 |
GREAT POINT PARTNERS LLC |
983,786 |
5,539,000 |
9.71% |
|
|
| 7 |
Ghost Tree Capital, LLC |
800,000 |
4,504,000 |
7.90% |
|
|
| 8 |
TURNER INVESTMENTS LLC |
226,750 |
1,277,000 |
2.24% |
|
|
| 9 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
125,700 |
708,000 |
1.24% |
Put |
|
| 10 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
80,300 |
452,000 |
0.79% |
Call |
|
| 11 |
MARSHALL WACE, LLP |
78,186 |
440,000 |
0.77% |
|
|
| 12 |
Palo Alto Investors LP |
73,188 |
412,000 |
0.72% |
|
|
| 13 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
63,481 |
357,000 |
0.63% |
|
|
| 14 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
51,000 |
343,000 |
0.60% |
|
|
| 15 |
Verition Fund Management LLC |
55,300 |
311,000 |
0.55% |
|
|
| 16 |
D. E. Shaw & Co., Inc. |
50,194 |
283,000 |
0.50% |
|
|
| 17 |
MORGAN STANLEY |
44,613 |
251,000 |
0.44% |
|
|
| 18 |
STIFEL FINANCIAL CORP |
39,300 |
221,000 |
0.39% |
|
|
| 19 |
GROUP ONE TRADING LLC |
32,028 |
180,000 |
0.32% |
|
|
| 20 |
CITADEL ADVISORS LLC |
14,662 |
83,000 |
0.15% |
|
|
| 21 |
GOLDMAN SACHS GROUP INC |
13,851 |
78,000 |
0.14% |
|
|
| 22 |
WELLS FARGO & COMPANY/MN |
5,418 |
30,000 |
0.05% |
|
|
| 23 |
UBS Group AG |
3,842 |
21,000 |
0.04% |
|
|
| 24 |
PRELUDE CAPITAL MANAGEMENT, LLC |
1,000 |
6,000 |
0.01% |
Call |
|
| 25 |
BANK OF AMERICA CORP /DE/ |
400 |
2,000 |
0.00% |
|
|
| 26 |
SPHERA FUNDS MANAGEMENT LTD. |
200 |
1,000 |
0.00% |
|
|
| 27 |
Tower Research Capital LLC (TRC) |
151 |
1,000 |
0.00% |
|
|
| 28 |
AMERICAN INTERNATIONAL GROUP, INC. |
150 |
845 |
0.00% |
|
|
| 29 |
NEXT Financial Group, Inc |
100 |
0 |
0.00% |
|
|
