| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JANUS HENDERSON INVESTORS US LLC | 7,019,774 | 90,344,000 | 10.92% | ||
| 2 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 4,584,694 | 59,005,012 | 7.13% | ||
| 3 | Essex Woodlands Management, Inc. | 1,165,428 | 51,550,000 | 6.23% | ||
| 4 | VANGUARD GROUP INC | 3,705,893 | 47,694,000 | 5.76% | ||
| 5 | GOLDMAN SACHS GROUP INC | 2,281,793 | 29,367,000 | 3.55% | ||
| 6 | PALISADE CAPITAL MANAGEMENT, LP | 2,264,173 | 29,140,000 | 3.52% | ||
| 7 | Clearbridge Investments, LLC | 2,085,748 | 26,844,000 | 3.24% | ||
| 8 | WELLS FARGO & COMPANY/MN | 2,049,401 | 26,375,000 | 3.19% | ||
| 9 | KING LUTHER CAPITAL MANAGEMENT CORP | 2,027,552 | 26,095,000 | 3.15% | ||
| 10 | EAGLE ASSET MANAGEMENT INC | 1,889,345 | 24,315,000 | 2.94% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,885,628 | 24,268,000 | 2.93% | ||
| 12 | FRED ALGER MANAGEMENT, LLC | 1,608,062 | 20,696,000 | 2.50% | ||
| 13 | BlackRock Fund Advisors | 1,596,198 | 20,543,000 | 2.48% | ||
| 14 | COLUMBUS CIRCLE INVESTORS | 1,467,950 | 18,893,000 | 2.28% | ||
| 15 | Bank of New York Mellon Corp | 1,434,154 | 18,458,000 | 2.23% | ||
| 16 | Tamarack Capital Management, LLC | 1,425,000 | 18,340,000 | 2.22% | ||
| 17 | ArrowMark Colorado Holdings LLC | 1,329,725 | 17,114,000 | 2.07% | ||
| 18 | BROWN ADVISORY INC | 1,166,207 | 15,009,000 | 1.81% | ||
| 19 | STATE STREET CORP | 1,127,754 | 14,513,000 | 1.75% | ||
| 20 | Polar Capital LLP | 1,100,000 | 14,155,000 | 1.71% | ||
| 21 | Cortina Asset Management, LLC | 960,926 | 12,367,000 | 1.49% | ||
| 22 | WADDELL & REED FINANCIAL INC | 923,600 | 11,886,000 | 1.44% | ||
| 23 | TCW GROUP INC | 899,750 | 11,580,000 | 1.40% | ||
| 24 | NORTHERN TRUST CORP | 899,587 | 11,578,000 | 1.40% | ||
| 25 | BANK OF MONTREAL /CAN/ | 838,167 | 10,787,000 | 1.30% | ||
| 26 | Redmile Group, LLC | 795,095 | 10,233,000 | 1.24% | ||
| 27 | BANK OF AMERICA CORP /DE/ | 783,915 | 10,090,000 | 1.22% | ||
| 28 | OppenheimerFunds, Inc. | 768,093 | 9,886,000 | 1.19% | ||
| 29 | DEERFIELD MANAGEMENT COMPANY, L.P. | 683,458 | 8,796,000 | 1.06% | ||
| 30 | AMUNDI ASSET MANAGEMENT US, INC. | 571,453 | 7,355,000 | 0.89% | ||
| 31 | Visium Asset Management, LP | 551,323 | 7,096,000 | 0.86% | ||
| 32 | CLEARBRIDGE, LLC | 535,380 | 6,890,000 | 0.83% | ||
| 33 | FIL Ltd | 465,065 | 5,985,000 | 0.72% | ||
| 34 | FMR LLC | 380,109 | 4,892,000 | 0.59% | ||
| 35 | MILLENNIUM MANAGEMENT LLC | 366,651 | 4,719,000 | 0.57% | ||
| 36 | AXA S.A. | 365,323 | 4,702,000 | 0.57% | ||
| 37 | Invesco Ltd. | 344,109 | 4,429,000 | 0.54% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 339,999 | 4,375,000 | 0.53% | ||
| 39 | Nuveen Asset Management, LLC | 312,371 | 4,020,000 | 0.49% | ||
| 40 | AMERIPRISE FINANCIAL INC | 303,538 | 3,907,000 | 0.47% | ||
| 41 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 292,837 | 3,769,000 | 0.46% | ||
| 42 | Allianz Asset Management GmbH | 288,729 | 3,716,000 | 0.45% | ||
| 43 | MACKENZIE FINANCIAL CORP | 284,500 | 3,662,000 | 0.44% | ||
| 44 | PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 263,777 | 3,395,000 | 0.41% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 244,033 | 3,141,000 | 0.38% | ||
| 46 | MANAGED ACCOUNT ADVISORS LLC | 219,841 | 2,829,000 | 0.34% | ||
| 47 | Rhenman & Partners Asset Management AB | 201,843 | 2,598,000 | 0.31% | ||
| 48 | Tygh Capital Management, Inc. | 198,399 | 2,553,000 | 0.31% | ||
| 49 | Iguana Healthcare Management, LLC | 192,500 | 2,477,000 | 0.30% | ||
| 50 | WASHINGTON CAPITAL MANAGEMENT, INC | 179,697 | 2,313,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
