| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JANUS HENDERSON INVESTORS US LLC | 8,020,718 | 85,020,000 | 12.13% | ||
| 2 | VANGUARD GROUP INC | 3,804,056 | 40,323,000 | 5.75% | ||
| 3 | Tamarack Capital Management, LLC | 3,300,000 | 34,980,000 | 4.99% | ||
| 4 | Essex Woodlands Management, Inc. | 2,514,936 | 31,644,000 | 4.51% | ||
| 5 | ArrowMark Colorado Holdings LLC | 2,669,602 | 28,298,000 | 4.04% | ||
| 6 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,501,526 | 26,516,000 | 3.78% | ||
| 7 | Bank of New York Mellon Corp | 2,339,526 | 24,799,000 | 3.54% | ||
| 8 | PALISADE CAPITAL MANAGEMENT, LP | 2,200,411 | 23,324,000 | 3.33% | ||
| 9 | Clearbridge Investments, LLC | 2,106,243 | 22,326,000 | 3.18% | ||
| 10 | EAGLE ASSET MANAGEMENT INC | 2,013,278 | 21,340,000 | 3.04% | ||
| 11 | KING LUTHER CAPITAL MANAGEMENT CORP | 1,963,077 | 20,809,000 | 2.97% | ||
| 12 | GOLDMAN SACHS GROUP INC | 1,902,066 | 20,162,000 | 2.88% | ||
| 13 | WELLS FARGO & COMPANY/MN | 1,863,841 | 19,757,000 | 2.82% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 1,845,313 | 19,560,000 | 2.79% | ||
| 15 | Polar Capital LLP | 1,438,070 | 15,242,000 | 2.17% | ||
| 16 | CITADEL ADVISORS LLC | 1,420,568 | 15,058,000 | 2.15% | ||
| 17 | BlackRock Fund Advisors | 1,378,563 | 14,613,000 | 2.08% | ||
| 18 | FRED ALGER MANAGEMENT, LLC | 1,288,719 | 13,660,000 | 1.95% | ||
| 19 | MILLENNIUM MANAGEMENT LLC | 1,227,971 | 13,016,000 | 1.86% | ||
| 20 | Cortina Asset Management, LLC | 1,166,879 | 12,369,000 | 1.76% | ||
| 21 | STATE STREET CORP | 1,071,075 | 11,350,000 | 1.62% | ||
| 22 | GREAT POINT PARTNERS LLC | 973,200 | 10,316,000 | 1.47% | ||
| 23 | FMR LLC | 916,333 | 9,713,000 | 1.39% | ||
| 24 | TCW GROUP INC | 899,099 | 9,531,000 | 1.36% | ||
| 25 | BANK OF MONTREAL /CAN/ | 893,772 | 9,475,000 | 1.35% | ||
| 26 | BANK OF AMERICA CORP /DE/ | 870,834 | 9,231,000 | 1.32% | ||
| 27 | NORTHERN TRUST CORP | 803,460 | 8,517,000 | 1.21% | ||
| 28 | AMUNDI ASSET MANAGEMENT US, INC. | 738,560 | 7,829,000 | 1.12% | ||
| 29 | MACKENZIE FINANCIAL CORP | 691,100 | 7,326,000 | 1.04% | ||
| 30 | BROWN ADVISORY INC | 642,321 | 6,809,000 | 0.97% | ||
| 31 | OppenheimerFunds, Inc. | 632,268 | 6,702,000 | 0.96% | ||
| 32 | FIL Ltd | 594,683 | 6,304,000 | 0.90% | ||
| 33 | WADDELL & REED FINANCIAL INC | 562,182 | 5,959,000 | 0.85% | ||
| 34 | Tekla Capital Management LLC | 551,000 | 5,841,000 | 0.83% | ||
| 35 | CLEARBRIDGE, LLC | 535,380 | 5,675,000 | 0.81% | ||
| 36 | ALTRINSIC GLOBAL ADVISORS LLC | 420,000 | 4,452,000 | 0.63% | ||
| 37 | AXA S.A. | 364,902 | 3,868,000 | 0.55% | ||
| 38 | Asset Management One Co., Ltd. | 354,350 | 3,848,000 | 0.55% | ||
| 39 | GEODE CAPITAL MANAGEMENT, LLC | 346,840 | 3,676,000 | 0.52% | ||
| 40 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 292,837 | 3,104,000 | 0.44% | ||
| 41 | Century Capital Management, LLC | 292,765 | 3,103,000 | 0.44% | ||
| 42 | CITY NATIONAL BANK | 290,319 | 3,078,000 | 0.44% | ||
| 43 | AMERIPRISE FINANCIAL INC | 268,408 | 2,845,000 | 0.41% | ||
| 44 | Nuveen Asset Management, LLC | 241,640 | 2,561,000 | 0.37% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 239,860 | 2,543,000 | 0.36% | ||
| 46 | First Light Asset Management, LLC | 231,599 | 2,455,000 | 0.35% | ||
| 47 | Point72 Asset Management, L.P. | 216,452 | 2,294,000 | 0.33% | ||
| 48 | Rhenman & Partners Asset Management AB | 200,000 | 2,120,000 | 0.30% | ||
| 49 | MANAGED ACCOUNT ADVISORS LLC | 195,879 | 2,077,000 | 0.30% | ||
| 50 | Allianz Asset Management GmbH | 185,910 | 1,971,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
