| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JANUS HENDERSON INVESTORS US LLC | 8,347,283 | 127,630,000 | 12.00% | ||
| 2 | Tamarack Capital Management, LLC | 3,960,000 | 60,548,000 | 5.69% | ||
| 3 | VANGUARD GROUP INC | 3,877,844 | 59,293,000 | 5.58% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,378,787 | 51,662,000 | 4.86% | ||
| 5 | ArrowMark Colorado Holdings LLC | 2,854,211 | 43,641,000 | 4.10% | ||
| 6 | Essex Woodlands Management, Inc. | 2,514,936 | 43,633,000 | 4.10% | ||
| 7 | WELLINGTON MANAGEMENT GROUP LLP | 2,834,542 | 43,341,000 | 4.08% | ||
| 8 | Bank of New York Mellon Corp | 2,787,572 | 42,621,000 | 4.01% | ||
| 9 | FMR LLC | 2,714,933 | 41,511,000 | 3.90% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 2,302,683 | 35,208,000 | 3.31% | ||
| 11 | Clearbridge Investments, LLC | 2,109,607 | 32,256,000 | 3.03% | ||
| 12 | PALISADE CAPITAL MANAGEMENT, LP | 2,033,806 | 31,097,000 | 2.92% | ||
| 13 | GOLDMAN SACHS GROUP INC | 2,018,410 | 30,862,000 | 2.90% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 1,830,890 | 27,994,000 | 2.63% | ||
| 15 | WELLS FARGO & COMPANY/MN | 1,781,571 | 27,241,000 | 2.56% | ||
| 16 | KING LUTHER CAPITAL MANAGEMENT CORP | 1,690,156 | 25,842,000 | 2.43% | ||
| 17 | BlackRock Fund Advisors | 1,617,377 | 24,730,000 | 2.33% | ||
| 18 | Polar Capital LLP | 1,150,000 | 17,584,000 | 1.65% | ||
| 19 | STATE STREET CORP | 1,098,011 | 16,788,000 | 1.58% | ||
| 20 | TCW GROUP INC | 932,930 | 14,264,000 | 1.34% | ||
| 21 | BANK OF AMERICA CORP /DE/ | 923,363 | 14,118,000 | 1.33% | ||
| 22 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 900,000 | 13,761,000 | 1.29% | ||
| 23 | EAGLE ASSET MANAGEMENT INC | 899,040 | 13,746,000 | 1.29% | ||
| 24 | NORTHERN TRUST CORP | 859,807 | 13,147,000 | 1.24% | ||
| 25 | MACKENZIE FINANCIAL CORP | 852,200 | 13,030,000 | 1.23% | ||
| 26 | Cortina Asset Management, LLC | 755,540 | 11,552,000 | 1.09% | ||
| 27 | AMUNDI ASSET MANAGEMENT US, INC. | 689,134 | 10,537,000 | 0.99% | ||
| 28 | GREAT POINT PARTNERS LLC | 650,000 | 9,939,000 | 0.93% | ||
| 29 | BANK OF MONTREAL /CAN/ | 642,602 | 9,825,000 | 0.92% | ||
| 30 | FIL Ltd | 604,972 | 9,250,000 | 0.87% | ||
| 31 | Asset Management One Co., Ltd. | 540,929 | 8,541,000 | 0.80% | ||
| 32 | Tekla Capital Management LLC | 551,000 | 8,425,000 | 0.79% | ||
| 33 | CLEARBRIDGE, LLC | 535,900 | 8,194,000 | 0.77% | ||
| 34 | STIFEL FINANCIAL CORP | 338,813 | 7,965,000 | 0.75% | ||
| 35 | WADDELL & REED FINANCIAL INC | 421,782 | 6,449,000 | 0.61% | ||
| 36 | ALTRINSIC GLOBAL ADVISORS LLC | 420,000 | 6,422,000 | 0.60% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 376,816 | 5,761,000 | 0.54% | ||
| 38 | Nuveen Asset Management, LLC | 371,556 | 5,681,000 | 0.53% | ||
| 39 | AXA S.A. | 366,125 | 5,598,000 | 0.53% | ||
| 40 | CITY NATIONAL BANK | 315,604 | 4,826,000 | 0.45% | ||
| 41 | First Light Asset Management, LLC | 250,369 | 3,828,000 | 0.36% | ||
| 42 | AMERIPRISE FINANCIAL INC | 237,396 | 3,630,000 | 0.34% | ||
| 43 | KENNEDY CAPITAL MANAGEMENT LLC | 229,660 | 3,512,000 | 0.33% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 228,586 | 3,495,000 | 0.33% | ||
| 45 | PERCEPTIVE ADVISORS LLC | 210,000 | 3,211,000 | 0.30% | ||
| 46 | GAM Holding AG | 200,000 | 3,058,000 | 0.29% | ||
| 47 | Rhenman & Partners Asset Management AB | 194,000 | 2,966,000 | 0.28% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 185,338 | 2,834,000 | 0.27% | ||
| 49 | PARADIGM ASSET MANAGEMENT CO LLC | 179,800 | 2,749,142 | 0.26% | ||
| 50 | BlackRock Investment Management, LLC | 174,362 | 2,666,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
