| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JANUS HENDERSON INVESTORS US LLC | 7,153,679 | 59,805,000 | 8.66% | ||
| 2 | CADIAN CAPITAL MANAGEMENT, LP | 5,989,400 | 50,071,000 | 7.25% | ||
| 3 | VANGUARD GROUP INC | 5,388,098 | 45,044,000 | 6.52% | ||
| 4 | ArrowMark Colorado Holdings LLC | 4,795,590 | 40,091,000 | 5.80% | ||
| 5 | GOLDMAN SACHS GROUP INC | 4,003,066 | 33,465,000 | 4.84% | ||
| 6 | Camber Capital Management LP | 3,864,500 | 32,307,000 | 4.68% | ||
| 7 | TAMARACK ADVISERS, LP | 3,800,000 | 31,768,000 | 4.60% | SH | |
| 8 | WELLINGTON MANAGEMENT GROUP LLP | 3,355,660 | 28,053,000 | 4.06% | ||
| 9 | Clearbridge Investments, LLC | 2,898,788 | 24,234,000 | 3.51% | ||
| 10 | TimesSquare Capital Management, LLC | 2,647,135 | 22,130,000 | 3.20% | ||
| 11 | NEA Management Company, LLC | 2,490,204 | 20,818,000 | 3.01% | ||
| 12 | Redmile Group, LLC | 2,468,847 | 20,640,000 | 2.99% | ||
| 13 | PALISADE CAPITAL MANAGEMENT, LP | 2,138,230 | 17,876,000 | 2.59% | ||
| 14 | Essex Woodlands Management, Inc. | 1,257,468 | 16,776,000 | 2.43% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 1,827,084 | 15,274,000 | 2.21% | ||
| 16 | BlackRock Fund Advisors | 1,746,376 | 14,600,000 | 2.11% | ||
| 17 | MACKENZIE FINANCIAL CORP | 1,572,245 | 13,144,000 | 1.90% | ||
| 18 | Elk Creek Partners, LLC | 1,292,432 | 10,805,000 | 1.56% | ||
| 19 | FMR LLC | 1,279,999 | 10,701,000 | 1.55% | ||
| 20 | STATE STREET CORP | 1,251,937 | 10,468,000 | 1.52% | ||
| 21 | Visium Asset Management, LP | 1,225,100 | 10,242,000 | 1.48% | ||
| 22 | MPM ASSET MANAGEMENT LLC | 1,121,447 | 9,375,000 | 1.36% | ||
| 23 | Broadfin Capital, LLC | 1,000,000 | 8,360,000 | 1.21% | ||
| 24 | NORTHERN TRUST CORP | 953,174 | 7,969,000 | 1.15% | ||
| 25 | Polar Capital LLP | 952,710 | 7,963,000 | 1.15% | ||
| 26 | FIL Ltd | 898,241 | 7,510,000 | 1.09% | ||
| 27 | MILLENNIUM MANAGEMENT LLC | 782,473 | 6,541,000 | 0.95% | ||
| 28 | AMUNDI ASSET MANAGEMENT US, INC. | 720,793 | 6,026,000 | 0.87% | ||
| 29 | CLEARBRIDGE, LLC | 691,681 | 5,782,000 | 0.84% | ||
| 30 | BANK OF AMERICA CORP /DE/ | 619,027 | 5,176,000 | 0.75% | ||
| 31 | BLACKROCK ADVISORS LLC | 616,839 | 5,157,000 | 0.75% | ||
| 32 | AXA S.A. | 585,437 | 4,894,000 | 0.71% | ||
| 33 | ALTRINSIC GLOBAL ADVISORS LLC | 580,000 | 4,849,000 | 0.70% | ||
| 34 | DEERFIELD MANAGEMENT COMPANY, L.P. | 569,895 | 4,764,000 | 0.69% | ||
| 35 | Tekla Capital Management LLC | 551,000 | 4,606,000 | 0.67% | ||
| 36 | First Light Asset Management, LLC | 530,129 | 4,432,000 | 0.64% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 483,205 | 4,039,000 | 0.58% | ||
| 38 | PURA VIDA INVESTMENTS, LLC | 436,100 | 3,646,000 | 0.53% | ||
| 39 | Rhenman & Partners Asset Management AB | 435,000 | 3,637,000 | 0.53% | ||
| 40 | WADDELL & REED FINANCIAL INC | 399,300 | 3,338,000 | 0.48% | ||
| 41 | RENAISSANCE TECHNOLOGIES LLC | 341,622 | 2,856,000 | 0.41% | ||
| 42 | Bank of New York Mellon Corp | 333,045 | 2,784,000 | 0.40% | ||
| 43 | BlackRock Investment Management, LLC | 328,656 | 2,748,000 | 0.40% | ||
| 44 | MARSHALL WACE, LLP | 283,797 | 2,373,000 | 0.34% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 247,936 | 2,073,000 | 0.30% | ||
| 46 | Asset Management One Co., Ltd. | 242,164 | 2,009,000 | 0.29% | ||
| 47 | BlackRock Group LTD | 234,987 | 1,965,000 | 0.28% | ||
| 48 | TIAA CREF INVESTMENT MANAGEMENT LLC | 222,697 | 1,862,000 | 0.27% | ||
| 49 | AMERIPRISE FINANCIAL INC | 211,778 | 1,771,000 | 0.26% | ||
| 50 | GAM Holding AG | 209,700 | 1,753,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
