| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JANUS HENDERSON INVESTORS US LLC | 7,345,861 | 91,529,000 | 7.96% | ||
| 2 | VANGUARD GROUP INC | 5,575,344 | 69,468,000 | 6.04% | ||
| 3 | BROWN CAPITAL MANAGEMENT LLC | 4,853,663 | 60,477,000 | 5.26% | ||
| 4 | ArrowMark Colorado Holdings LLC | 4,686,039 | 58,388,000 | 5.08% | ||
| 5 | CADIAN CAPITAL MANAGEMENT, LP | 4,033,023 | 50,251,000 | 4.37% | ||
| 6 | Redmile Group, LLC | 3,962,753 | 49,376,000 | 4.30% | ||
| 7 | TimesSquare Capital Management, LLC | 3,136,135 | 39,076,000 | 3.40% | ||
| 8 | Camber Capital Management LP | 3,000,000 | 37,380,000 | 3.25% | ||
| 9 | TAMARACK ADVISERS, LP | 2,910,000 | 36,259,000 | 3.15% | ||
| 10 | Clearbridge Investments, LLC | 2,854,779 | 35,571,000 | 3.09% | ||
| 11 | GOLDMAN SACHS GROUP INC | 2,730,626 | 34,023,000 | 2.96% | ||
| 12 | WELLINGTON MANAGEMENT GROUP LLP | 2,724,500 | 33,947,000 | 2.95% | ||
| 13 | NEA Management Company, LLC | 2,490,204 | 31,028,000 | 2.70% | ||
| 14 | BlackRock Fund Advisors | 1,923,027 | 23,961,000 | 2.08% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 1,889,966 | 23,549,000 | 2.05% | ||
| 16 | MACKENZIE FINANCIAL CORP | 1,800,920 | 22,439,000 | 1.95% | ||
| 17 | Essex Woodlands Management, Inc. | 1,257,468 | 22,174,000 | 1.93% | ||
| 18 | PALISADE CAPITAL MANAGEMENT, LP | 1,717,482 | 21,400,000 | 1.86% | ||
| 19 | PFM Health Sciences, LP | 1,558,942 | 19,424,000 | 1.69% | ||
| 20 | Elk Creek Partners, LLC | 1,482,885 | 18,477,000 | 1.61% | ||
| 21 | STATE STREET CORP | 1,334,295 | 16,627,000 | 1.45% | ||
| 22 | FMR LLC | 1,279,999 | 15,949,000 | 1.39% | ||
| 23 | AMERIPRISE FINANCIAL INC | 1,156,342 | 14,401,000 | 1.25% | ||
| 24 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 1,149,943 | 14,328,000 | 1.25% | ||
| 25 | MPM ASSET MANAGEMENT LLC | 1,121,447 | 13,973,000 | 1.22% | ||
| 26 | NORTHERN TRUST CORP | 1,027,724 | 12,804,000 | 1.11% | ||
| 27 | Broadfin Capital, LLC | 1,000,000 | 12,460,000 | 1.08% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 952,798 | 11,872,000 | 1.03% | ||
| 29 | FIL Ltd | 901,389 | 11,232,000 | 0.98% | ||
| 30 | BANK OF AMERICA CORP /DE/ | 891,996 | 11,115,000 | 0.97% | ||
| 31 | BNP Paribas Asset Management Holding S.A. | 850,249 | 10,594,000 | 0.92% | ||
| 32 | Polar Capital LLP | 847,669 | 10,560,000 | 0.92% | ||
| 33 | NEW YORK STATE COMMON RETIREMENT FUND | 831,508 | 10,361,000 | 0.90% | ||
| 34 | SENZAR ASSET MANAGEMENT, LLC | 809,800 | 10,090,108 | 0.88% | ||
| 35 | CLEARBRIDGE, LLC | 730,211 | 9,098,000 | 0.79% | ||
| 36 | AMUNDI ASSET MANAGEMENT US, INC. | 719,624 | 8,967,000 | 0.78% | ||
| 37 | BLACKROCK ADVISORS LLC | 656,439 | 8,180,000 | 0.71% | ||
| 38 | AXA S.A. | 593,619 | 7,396,000 | 0.64% | ||
| 39 | ALTRINSIC GLOBAL ADVISORS LLC | 560,000 | 6,978,000 | 0.61% | ||
| 40 | Tekla Capital Management LLC | 551,000 | 6,865,000 | 0.60% | ||
| 41 | GEODE CAPITAL MANAGEMENT, LLC | 505,393 | 6,297,000 | 0.55% | ||
| 42 | Bank of New York Mellon Corp | 466,721 | 5,815,000 | 0.51% | ||
| 43 | Rhenman & Partners Asset Management AB | 435,000 | 5,420,000 | 0.47% | ||
| 44 | GAM Holding AG | 419,400 | 5,226,000 | 0.45% | ||
| 45 | WADDELL & REED FINANCIAL INC | 411,800 | 5,131,000 | 0.45% | ||
| 46 | PICTET ASSET MANAGEMENT LTD | 397,534 | 5,037,000 | 0.44% | ||
| 47 | Ghost Tree Capital, LLC | 400,000 | 4,984,000 | 0.43% | ||
| 48 | LORD, ABBETT & CO. LLC | 376,731 | 4,694,000 | 0.41% | ||
| 49 | BlackRock Investment Management, LLC | 375,948 | 4,684,000 | 0.41% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 264,524 | 3,296,000 | 0.29% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
