| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JANUS HENDERSON INVESTORS US LLC | 7,270,670 | 71,980,000 | 9.92% | ||
| 2 | CADIAN CAPITAL MANAGEMENT, LP | 5,676,342 | 56,196,000 | 7.75% | ||
| 3 | TAMARACK ADVISERS, LP | 4,475,000 | 44,303,000 | 6.11% | ||
| 4 | VANGUARD GROUP INC | 4,471,383 | 44,267,000 | 6.10% | ||
| 5 | GOLDMAN SACHS GROUP INC | 4,280,619 | 42,378,000 | 5.84% | ||
| 6 | WELLINGTON MANAGEMENT GROUP LLP | 3,872,161 | 38,334,000 | 5.28% | ||
| 7 | ArrowMark Colorado Holdings LLC | 3,534,787 | 34,994,000 | 4.82% | ||
| 8 | TimesSquare Capital Management, LLC | 2,657,600 | 26,310,000 | 3.63% | ||
| 9 | Clearbridge Investments, LLC | 2,499,503 | 24,745,000 | 3.41% | ||
| 10 | LORD, ABBETT & CO. LLC | 2,080,100 | 20,593,000 | 2.84% | ||
| 11 | PALISADE CAPITAL MANAGEMENT, LP | 2,057,286 | 20,367,000 | 2.81% | ||
| 12 | Essex Woodlands Management, Inc. | 1,257,468 | 18,480,000 | 2.55% | ||
| 13 | Polar Capital LLP | 1,852,801 | 18,341,000 | 2.53% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 1,747,730 | 17,303,000 | 2.39% | ||
| 15 | BlackRock Fund Advisors | 1,664,693 | 16,480,000 | 2.27% | ||
| 16 | MACKENZIE FINANCIAL CORP | 1,559,300 | 15,437,000 | 2.13% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 1,471,894 | 14,572,000 | 2.01% | ||
| 18 | STATE STREET CORP | 1,176,148 | 11,650,000 | 1.61% | ||
| 19 | Elk Creek Partners, LLC | 1,139,313 | 11,279,000 | 1.55% | ||
| 20 | Redmile Group, LLC | 1,007,177 | 9,971,000 | 1.37% | ||
| 21 | Broadfin Capital, LLC | 1,000,000 | 9,900,000 | 1.36% | ||
| 22 | NORTHERN TRUST CORP | 947,132 | 9,377,000 | 1.29% | ||
| 23 | FMR LLC | 900,000 | 8,910,000 | 1.23% | ||
| 24 | Visium Asset Management, LP | 875,100 | 8,663,000 | 1.19% | ||
| 25 | AMUNDI ASSET MANAGEMENT US, INC. | 843,312 | 8,349,000 | 1.15% | ||
| 26 | BANK OF AMERICA CORP /DE/ | 789,493 | 7,816,000 | 1.08% | ||
| 27 | First Light Asset Management, LLC | 702,824 | 6,958,000 | 0.96% | ||
| 28 | CLEARBRIDGE, LLC | 619,510 | 6,133,000 | 0.85% | ||
| 29 | BLACKROCK ADVISORS LLC | 610,165 | 6,040,000 | 0.83% | ||
| 30 | Tekla Capital Management LLC | 551,000 | 5,455,000 | 0.75% | ||
| 31 | ALTRINSIC GLOBAL ADVISORS LLC | 530,000 | 5,247,000 | 0.72% | ||
| 32 | FIL Ltd | 513,738 | 5,086,000 | 0.70% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 439,018 | 4,346,000 | 0.60% | ||
| 34 | Rhenman & Partners Asset Management AB | 420,000 | 4,158,000 | 0.57% | ||
| 35 | WADDELL & REED FINANCIAL INC | 399,300 | 3,953,000 | 0.54% | ||
| 36 | AXA S.A. | 384,042 | 3,802,000 | 0.52% | ||
| 37 | OXFORD ASSET MANAGEMENT LLP | 342,657 | 3,432,000 | 0.47% | ||
| 38 | BlackRock Investment Management, LLC | 319,203 | 3,160,000 | 0.44% | ||
| 39 | PERCEPTIVE ADVISORS LLC | 300,000 | 2,970,000 | 0.41% | ||
| 40 | Bank of New York Mellon Corp | 293,721 | 2,908,000 | 0.40% | ||
| 41 | PURA VIDA INVESTMENTS, LLC | 270,000 | 2,673,000 | 0.37% | ||
| 42 | BlackRock Group LTD | 257,327 | 2,547,000 | 0.35% | ||
| 43 | Asset Management One Co., Ltd. | 244,941 | 2,476,000 | 0.34% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 213,524 | 2,114,000 | 0.29% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 211,259 | 2,092,000 | 0.29% | ||
| 46 | GAM Holding AG | 209,700 | 2,076,000 | 0.29% | ||
| 47 | A.R.T. Advisors, LLC | 197,109 | 1,951,000 | 0.27% | ||
| 48 | AMERIPRISE FINANCIAL INC | 189,303 | 1,874,000 | 0.26% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 150,020 | 1,485,000 | 0.20% | ||
| 50 | DEUTSCHE BANK AG\ | 149,215 | 1,475,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
