| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JANUS HENDERSON INVESTORS US LLC | 7,701,898 | 117,146,000 | 11.69% | ||
| 2 | Essex Woodlands Management, Inc. | 2,814,936 | 60,066,000 | 5.99% | ||
| 3 | VANGUARD GROUP INC | 3,678,180 | 55,946,000 | 5.58% | ||
| 4 | ArrowMark Colorado Holdings LLC | 2,514,546 | 38,246,000 | 3.82% | ||
| 5 | GOLDMAN SACHS GROUP INC | 2,439,202 | 37,101,000 | 3.70% | ||
| 6 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 2,309,078 | 35,121,000 | 3.51% | ||
| 7 | EAGLE ASSET MANAGEMENT INC | 2,229,308 | 33,907,000 | 3.38% | ||
| 8 | Tamarack Capital Management, LLC | 2,375,000 | 33,583,000 | 3.35% | ||
| 9 | PALISADE CAPITAL MANAGEMENT, LP | 2,198,877 | 33,445,000 | 3.34% | ||
| 10 | Clearbridge Investments, LLC | 2,092,872 | 31,833,000 | 3.18% | ||
| 11 | KING LUTHER CAPITAL MANAGEMENT CORP | 1,998,727 | 30,401,000 | 3.03% | ||
| 12 | Bank of New York Mellon Corp | 1,970,684 | 29,974,000 | 2.99% | ||
| 13 | WELLS FARGO & COMPANY/MN | 1,958,623 | 29,791,000 | 2.97% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 1,847,663 | 28,103,000 | 2.80% | ||
| 15 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,481,928 | 22,540,000 | 2.25% | ||
| 16 | BlackRock Fund Advisors | 1,411,558 | 21,470,000 | 2.14% | ||
| 17 | FRED ALGER MANAGEMENT, LLC | 1,371,655 | 20,863,000 | 2.08% | ||
| 18 | COLUMBUS CIRCLE INVESTORS | 1,351,908 | 20,563,000 | 2.05% | ||
| 19 | BROWN ADVISORY INC | 1,226,235 | 18,651,000 | 1.86% | ||
| 20 | Polar Capital LLP | 1,150,000 | 17,492,000 | 1.75% | ||
| 21 | Cortina Asset Management, LLC | 1,145,103 | 17,417,000 | 1.74% | ||
| 22 | STATE STREET CORP | 1,092,123 | 16,609,000 | 1.66% | ||
| 23 | CITADEL ADVISORS LLC | 925,760 | 14,081,000 | 1.41% | ||
| 24 | WADDELL & REED FINANCIAL INC | 923,600 | 14,048,000 | 1.40% | ||
| 25 | FMR LLC | 919,433 | 13,985,000 | 1.40% | ||
| 26 | TCW GROUP INC | 915,570 | 13,926,000 | 1.39% | ||
| 27 | BANK OF AMERICA CORP /DE/ | 887,610 | 13,500,000 | 1.35% | ||
| 28 | BANK OF MONTREAL /CAN/ | 849,605 | 12,923,000 | 1.29% | ||
| 29 | NORTHERN TRUST CORP | 779,607 | 11,857,000 | 1.18% | ||
| 30 | OppenheimerFunds, Inc. | 634,994 | 9,658,000 | 0.96% | ||
| 31 | MILLENNIUM MANAGEMENT LLC | 631,000 | 9,598,000 | 0.96% | ||
| 32 | FIL Ltd | 592,792 | 9,016,000 | 0.90% | ||
| 33 | AMUNDI ASSET MANAGEMENT US, INC. | 585,991 | 8,913,000 | 0.89% | ||
| 34 | CLEARBRIDGE, LLC | 535,380 | 8,143,000 | 0.81% | ||
| 35 | ALTRINSIC GLOBAL ADVISORS LLC | 420,000 | 6,388,000 | 0.64% | ||
| 36 | AXA S.A. | 358,100 | 5,447,000 | 0.54% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 342,452 | 5,208,000 | 0.52% | ||
| 38 | Tygh Capital Management, Inc. | 296,446 | 4,509,000 | 0.45% | ||
| 39 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 292,837 | 4,454,000 | 0.44% | ||
| 40 | AMERIPRISE FINANCIAL INC | 291,168 | 4,429,000 | 0.44% | ||
| 41 | MACKENZIE FINANCIAL CORP | 290,300 | 4,415,000 | 0.44% | ||
| 42 | CITY NATIONAL BANK | 275,369 | 4,189,000 | 0.42% | ||
| 43 | Nuveen Asset Management, LLC | 259,978 | 3,954,000 | 0.39% | ||
| 44 | Allianz Asset Management GmbH | 253,213 | 3,851,000 | 0.38% | ||
| 45 | Elk Creek Partners, LLC | 244,795 | 3,723,000 | 0.37% | ||
| 46 | TIAA CREF INVESTMENT MANAGEMENT LLC | 243,017 | 3,696,000 | 0.37% | ||
| 47 | MANAGED ACCOUNT ADVISORS LLC | 210,258 | 3,198,000 | 0.32% | ||
| 48 | Rhenman & Partners Asset Management AB | 205,000 | 3,118,000 | 0.31% | ||
| 49 | Iguana Healthcare Management, LLC | 195,000 | 2,966,000 | 0.30% | ||
| 50 | GREAT POINT PARTNERS LLC | 193,282 | 2,940,000 | 0.29% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
