| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JANUS HENDERSON INVESTORS US LLC | 7,425,713 | 95,049,000 | 7.93% | ||
| 2 | VANGUARD GROUP INC | 5,778,983 | 73,971,000 | 6.17% | ||
| 3 | ArrowMark Colorado Holdings LLC | 5,455,672 | 69,833,000 | 5.82% | ||
| 4 | BROWN CAPITAL MANAGEMENT LLC | 5,050,293 | 64,644,000 | 5.39% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 3,712,636 | 47,522,000 | 3.96% | ||
| 6 | Redmile Group, LLC | 3,480,644 | 44,552,000 | 3.72% | ||
| 7 | TimesSquare Capital Management, LLC | 3,394,785 | 43,453,000 | 3.62% | ||
| 8 | Clearbridge Investments, LLC | 2,853,606 | 36,526,000 | 3.05% | ||
| 9 | CADIAN CAPITAL MANAGEMENT, LP | 2,844,224 | 36,406,000 | 3.04% | ||
| 10 | TAMARACK ADVISERS, LP | 2,886,500 | 35,728,000 | 2.98% | ||
| 11 | NEA Management Company, LLC | 2,490,204 | 31,875,000 | 2.66% | ||
| 12 | Elk Creek Partners, LLC | 2,182,278 | 27,933,000 | 2.33% | ||
| 13 | BlackRock Fund Advisors | 2,055,818 | 26,314,000 | 2.19% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 1,919,832 | 24,574,000 | 2.05% | ||
| 15 | FMR LLC | 1,881,647 | 24,085,000 | 2.01% | ||
| 16 | MACKENZIE FINANCIAL CORP | 1,844,214 | 23,606,000 | 1.97% | ||
| 17 | Essex Woodlands Management, Inc. | 1,257,468 | 22,855,000 | 1.91% | ||
| 18 | GOLDMAN SACHS GROUP INC | 1,667,253 | 21,341,000 | 1.78% | ||
| 19 | PALISADE CAPITAL MANAGEMENT, LP | 1,641,429 | 21,010,000 | 1.75% | ||
| 20 | STATE STREET CORP | 1,446,694 | 18,518,000 | 1.54% | ||
| 21 | BNP Paribas Asset Management Holding S.A. | 1,230,673 | 15,753,000 | 1.31% | ||
| 22 | COLUMBIA WANGER ASSET MANAGEMENT LLC | 1,122,185 | 14,364,000 | 1.20% | ||
| 23 | MPM ASSET MANAGEMENT LLC | 1,121,447 | 14,355,000 | 1.20% | ||
| 24 | SENZAR ASSET MANAGEMENT, LLC | 1,087,700 | 13,922,560 | 1.16% | ||
| 25 | AMERIPRISE FINANCIAL INC | 1,079,930 | 13,816,000 | 1.15% | ||
| 26 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,048,200 | 13,417,000 | 1.12% | ||
| 27 | NORTHERN TRUST CORP | 1,043,773 | 13,361,000 | 1.11% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 1,036,400 | 13,266,000 | 1.11% | ||
| 29 | Polar Capital LLP | 1,029,000 | 13,169,000 | 1.10% | ||
| 30 | Camber Capital Management LP | 1,000,000 | 12,800,000 | 1.07% | ||
| 31 | AMUNDI ASSET MANAGEMENT US, INC. | 962,869 | 12,325,000 | 1.03% | ||
| 32 | FIL Ltd | 878,650 | 11,246,000 | 0.94% | ||
| 33 | PICTET ASSET MANAGEMENT LTD | 876,208 | 11,216,000 | 0.94% | ||
| 34 | NEW YORK STATE COMMON RETIREMENT FUND | 846,808 | 10,839,000 | 0.90% | ||
| 35 | Broadfin Capital, LLC | 800,000 | 10,240,000 | 0.85% | ||
| 36 | Tekla Capital Management LLC | 773,500 | 9,901,000 | 0.83% | ||
| 37 | BANK OF AMERICA CORP /DE/ | 767,655 | 9,826,000 | 0.82% | ||
| 38 | Bank of New York Mellon Corp | 761,904 | 9,752,000 | 0.81% | ||
| 39 | CLEARBRIDGE, LLC | 726,811 | 9,303,000 | 0.78% | ||
| 40 | NORGES BANK | 739,328 | 9,039,000 | 0.75% | ||
| 41 | AXA S.A. | 673,998 | 8,627,000 | 0.72% | ||
| 42 | BLACKROCK ADVISORS LLC | 632,956 | 8,102,000 | 0.68% | ||
| 43 | GEODE CAPITAL MANAGEMENT, LLC | 575,097 | 7,361,000 | 0.61% | ||
| 44 | ALTRINSIC GLOBAL ADVISORS LLC | 560,000 | 7,168,000 | 0.60% | ||
| 45 | PFM Health Sciences, LP | 535,695 | 6,857,000 | 0.57% | ||
| 46 | WADDELL & REED FINANCIAL INC | 444,500 | 5,689,000 | 0.47% | ||
| 47 | Rhenman & Partners Asset Management AB | 435,000 | 5,568,000 | 0.46% | ||
| 48 | DRIEHAUS CAPITAL MANAGEMENT LLC | 397,386 | 5,087,000 | 0.42% | ||
| 49 | LORD, ABBETT & CO. LLC | 381,737 | 4,886,000 | 0.41% | ||
| 50 | BlackRock Investment Management, LLC | 379,750 | 4,861,000 | 0.41% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
