| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 7,014,015 | 17,956,000 | 20.33% | ||
| 2 | VANGUARD GROUP INC | 3,841,194 | 9,834,000 | 11.13% | ||
| 3 | NATIXIS | 3,148,916 | 8,061,000 | 9.13% | ||
| 4 | JPMORGAN CHASE & CO | 3,006,375 | 7,696,000 | 8.71% | ||
| 5 | BlackRock Institutional Trust Company, N.A. | 2,467,717 | 6,317,000 | 7.15% | ||
| 6 | BlackRock Fund Advisors | 2,450,736 | 6,274,000 | 7.10% | ||
| 7 | Broadfin Capital, LLC | 2,427,745 | 6,215,000 | 7.04% | ||
| 8 | STATE STREET CORP | 1,391,150 | 3,559,000 | 4.03% | ||
| 9 | Palo Alto Investors LP | 1,257,748 | 3,220,000 | 3.65% | ||
| 10 | NORTHERN TRUST CORP | 983,775 | 2,519,000 | 2.85% | ||
| 11 | Alyeska Investment Group, L.P. | 880,826 | 2,255,000 | 2.55% | ||
| 12 | GEODE CAPITAL MANAGEMENT, LLC | 716,449 | 1,834,000 | 2.08% | ||
| 13 | WALL STREET ASSOCIATES | 400,000 | 1,024,000 | 1.16% | ||
| 14 | BlackRock Investment Management, LLC | 361,750 | 926,000 | 1.05% | ||
| 15 | Bank of New York Mellon Corp | 315,228 | 806,000 | 0.91% | ||
| 16 | TIAA CREF INVESTMENT MANAGEMENT LLC | 289,608 | 741,000 | 0.84% | ||
| 17 | MYCIO WEALTH PARTNERS, LLC | 246,527 | 631,000 | 0.71% | ||
| 18 | MILLENNIUM MANAGEMENT LLC | 210,429 | 539,000 | 0.61% | ||
| 19 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 188,393 | 482,000 | 0.55% | ||
| 20 | D. E. Shaw & Co., Inc. | 185,164 | 474,000 | 0.54% | ||
| 21 | DEUTSCHE BANK AG\ | 182,395 | 466,000 | 0.53% | ||
| 22 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 167,600 | 429,000 | 0.49% | ||
| 23 | DIMENSIONAL FUND ADVISORS LP | 167,318 | 428,000 | 0.48% | ||
| 24 | TEACHERS ADVISORS, LLC | 140,681 | 360,000 | 0.41% | ||
| 25 | Creative Planning | 131,100 | 336,000 | 0.38% | ||
| 26 | GROUP ONE TRADING LLC | 113,498 | 291,000 | 0.33% | ||
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 111,929 | 287,000 | 0.32% | ||
| 28 | Compagnie Lombard Odier SCmA | 110,000 | 282,000 | 0.32% | ||
| 29 | RHUMBLINE ADVISERS | 89,564 | 229,000 | 0.26% | ||
| 30 | LEAVELL INVESTMENT MANAGEMENT, INC. | 81,271 | 208,000 | 0.24% | ||
| 31 | NEW YORK STATE COMMON RETIREMENT FUND | 78,200 | 200,000 | 0.23% | ||
| 32 | Virtu KCG Holdings LLC | 74,351 | 190,000 | 0.22% | ||
| 33 | SIMPLEX TRADING, LLC | 71,935 | 184,000 | 0.21% | ||
| 34 | GSA CAPITAL PARTNERS LLP | 70,488 | 180,000 | 0.20% | ||
| 35 | ALLIANCEBERNSTEIN L.P. | 62,500 | 160,000 | 0.18% | ||
| 36 | GOLDMAN SACHS GROUP INC | 60,455 | 155,000 | 0.18% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 59,700 | 153,000 | 0.17% | Call | |
| 38 | Nationwide Fund Advisors | 58,157 | 149,000 | 0.17% | ||
| 39 | MORGAN STANLEY | 54,030 | 137,000 | 0.16% | ||
| 40 | AMERICAN INTERNATIONAL GROUP, INC. | 51,331 | 131,407 | 0.15% | ||
| 41 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 51,233 | 131,000 | 0.15% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 48,200 | 123,000 | 0.14% | Put | |
| 43 | BLACKROCK ADVISORS LLC | 47,166 | 121,000 | 0.14% | ||
| 44 | WELLS FARGO & COMPANY/MN | 46,810 | 120,000 | 0.14% | ||
| 45 | CITADEL ADVISORS LLC | 46,025 | 118,000 | 0.13% | ||
| 46 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 42,273 | 109,000 | 0.12% | ||
| 47 | EMERALD ACQUISITION LTD. | 39,185 | 100,000 | 0.11% | ||
| 48 | VOYA INVESTMENT MANAGEMENT LLC | 38,826 | 99,000 | 0.11% | ||
| 49 | Commonwealth Equity Services, Inc | 34,600 | 89,000 | 0.10% | ||
| 50 | CREDIT SUISSE AG/ | 32,544 | 83,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
