| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,939,366 | 59,750,000 | 24.40% | ||
| 2 | FMR LLC | 2,469,999 | 24,848,000 | 10.15% | ||
| 3 | SECTORAL ASSET MANAGEMENT INC | 1,790,715 | 18,015,000 | 7.36% | ||
| 4 | Broadfin Capital, LLC | 1,690,517 | 17,007,000 | 6.95% | ||
| 5 | STATE STREET CORP | 1,683,646 | 16,934,000 | 6.92% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,567,715 | 15,771,000 | 6.44% | ||
| 7 | VANGUARD GROUP INC | 1,190,973 | 11,981,000 | 4.89% | ||
| 8 | BlackRock Fund Advisors | 822,829 | 8,278,000 | 3.38% | ||
| 9 | Cormorant Asset Management, LP | 800,000 | 8,048,000 | 3.29% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 716,594 | 7,209,000 | 2.94% | ||
| 11 | ORBIMED ADVISORS LLC | 636,600 | 6,404,000 | 2.62% | ||
| 12 | Jefferies Group LLC | 553,800 | 5,571,000 | 2.28% | Call | |
| 13 | NORTHERN TRUST CORP | 353,444 | 3,556,000 | 1.45% | ||
| 14 | Knoll Capital Management, LLC | 275,000 | 2,767,000 | 1.13% | ||
| 15 | Jefferies Group LLC | 181,500 | 1,826,000 | 0.75% | Put | |
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 181,452 | 1,825,000 | 0.75% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 172,400 | 1,734,000 | 0.71% | Put | |
| 18 | PICTET ASSET MANAGEMENT LTD | 169,500 | 1,705,000 | 0.70% | ||
| 19 | OXFORD ASSET MANAGEMENT LLP | 146,282 | 1,502,000 | 0.61% | ||
| 20 | FRANKLIN STREET ADVISORS INC /NC | 144,900 | 1,458,000 | 0.60% | ||
| 21 | UBS Group AG | 143,008 | 1,438,000 | 0.59% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 134,364 | 1,352,000 | 0.55% | ||
| 23 | Bank of New York Mellon Corp | 131,875 | 1,327,000 | 0.54% | ||
| 24 | CREDIT SUISSE AG/ | 129,091 | 1,298,000 | 0.53% | ||
| 25 | Allianz Asset Management GmbH | 118,942 | 1,197,000 | 0.49% | ||
| 26 | GRATICULE ASIA MACRO ADVISORS LLC | 112,000 | 1,126,000 | 0.46% | ||
| 27 | BlackRock Investment Management, LLC | 108,426 | 1,091,000 | 0.45% | ||
| 28 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 103,500 | 1,041,000 | 0.43% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 95,956 | 965,000 | 0.39% | ||
| 30 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 87,850 | 884,000 | 0.36% | ||
| 31 | Vident Investment Advisory, LLC | 73,553 | 740,000 | 0.30% | ||
| 32 | TD ASSET MANAGEMENT INC | 68,758 | 692,000 | 0.28% | ||
| 33 | Trexquant Investment LP | 60,879 | 612,000 | 0.25% | ||
| 34 | D.A. DAVIDSON & CO. | 60,000 | 603,000 | 0.25% | ||
| 35 | Jefferies Group LLC | 59,757 | 601,000 | 0.25% | ||
| 36 | TEACHERS ADVISORS, LLC | 57,059 | 574,000 | 0.23% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 56,156 | 565,000 | 0.23% | ||
| 38 | NEXTHERA CAPITAL LP | 55,264 | 556,000 | 0.23% | ||
| 39 | Weiss Multi-Strategy Advisers LLC | 51,000 | 513,000 | 0.21% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 44,111 | 444,000 | 0.18% | ||
| 41 | CITADEL ADVISORS LLC | 41,330 | 416,000 | 0.17% | ||
| 42 | D. E. Shaw & Co., Inc. | 40,000 | 402,000 | 0.16% | Put | |
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 39,900 | 401,000 | 0.16% | Call | |
| 44 | ALLIANCEBERNSTEIN L.P. | 38,100 | 390,000 | 0.16% | ||
| 45 | Swiss National Bank | 38,100 | 383,000 | 0.16% | ||
| 46 | MORGAN STANLEY | 37,636 | 378,000 | 0.15% | ||
| 47 | Birchview Capital, LP | 35,600 | 358,000 | 0.15% | ||
| 48 | AQR CAPITAL MANAGEMENT LLC | 34,160 | 344,000 | 0.14% | ||
| 49 | VIRTUS ETF ADVISERS LLC | 33,234 | 334,000 | 0.14% | ||
| 50 | BANK OF MONTREAL /CAN/ | 32,879 | 330,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
