| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,639,366 | 114,648,000 | 27.77% | ||
| 2 | FMR LLC | 2,364,405 | 48,068,000 | 11.64% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,281,455 | 46,382,000 | 11.23% | ||
| 4 | Broadfin Capital, LLC | 1,450,094 | 29,480,000 | 7.14% | ||
| 5 | VANGUARD GROUP INC | 983,054 | 19,985,000 | 4.84% | ||
| 6 | Cormorant Asset Management, LP | 800,000 | 16,264,000 | 3.94% | ||
| 7 | BlackRock Fund Advisors | 799,213 | 16,248,000 | 3.94% | ||
| 8 | ORBIMED ADVISORS LLC | 755,100 | 15,351,000 | 3.72% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 596,768 | 12,132,000 | 2.94% | ||
| 10 | Tourbillon Capital Partners, L.P. | 550,000 | 11,182,000 | 2.71% | ||
| 11 | Rock Springs Capital Management LP | 417,500 | 8,488,000 | 2.06% | ||
| 12 | GRATICULE ASIA MACRO ADVISORS LLC | 332,874 | 6,767,000 | 1.64% | ||
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 201,500 | 4,096,000 | 0.99% | Put | |
| 14 | GEODE CAPITAL MANAGEMENT, LLC | 160,681 | 3,266,000 | 0.79% | ||
| 15 | A.R.T. Advisors, LLC | 157,444 | 3,200,000 | 0.78% | ||
| 16 | Bank of New York Mellon Corp | 146,754 | 2,983,000 | 0.72% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 143,500 | 2,917,000 | 0.71% | Call | |
| 18 | GOLDMAN SACHS GROUP INC | 139,029 | 2,826,000 | 0.68% | ||
| 19 | FRANKLIN STREET ADVISORS INC /NC | 116,700 | 2,372,000 | 0.57% | ||
| 20 | CITY NATIONAL BANK | 108,310 | 2,202,000 | 0.53% | ||
| 21 | BlackRock Investment Management, LLC | 108,181 | 2,199,000 | 0.53% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 103,315 | 2,100,000 | 0.51% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 102,199 | 2,078,000 | 0.50% | ||
| 24 | Jefferies Group LLC | 100,000 | 2,033,000 | 0.49% | Put | |
| 25 | Weiss Multi-Strategy Advisers LLC | 100,000 | 2,033,000 | 0.49% | ||
| 26 | TD ASSET MANAGEMENT INC | 97,158 | 1,975,000 | 0.48% | ||
| 27 | NORTHERN TRUST CORP | 89,955 | 1,829,000 | 0.44% | ||
| 28 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 88,600 | 1,801,000 | 0.44% | ||
| 29 | DEUTSCHE BANK AG\ | 67,013 | 1,361,000 | 0.33% | ||
| 30 | D.A. DAVIDSON & CO. | 64,000 | 1,301,000 | 0.32% | ||
| 31 | Jefferies Group LLC | 63,286 | 1,287,000 | 0.31% | ||
| 32 | MORGAN STANLEY | 56,371 | 1,146,000 | 0.28% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 55,357 | 1,125,000 | 0.27% | ||
| 34 | AQR CAPITAL MANAGEMENT LLC | 47,894 | 974,000 | 0.24% | ||
| 35 | CREDIT SUISSE AG/ | 47,763 | 971,000 | 0.24% | ||
| 36 | NumerixS Investment Technologies Inc | 45,200 | 919,000 | 0.22% | ||
| 37 | TEACHERS ADVISORS, LLC | 44,212 | 899,000 | 0.22% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 44,111 | 897,000 | 0.22% | ||
| 39 | ALLIANCEBERNSTEIN L.P. | 38,100 | 775,000 | 0.19% | ||
| 40 | Birchview Capital, LP | 35,600 | 724,000 | 0.18% | ||
| 41 | Quantitative Investment Management, LLC | 34,900 | 709,000 | 0.17% | ||
| 42 | WELLINGTON MANAGEMENT GROUP LLP | 34,820 | 708,000 | 0.17% | ||
| 43 | BANK OF AMERICA CORP /DE/ | 33,190 | 675,000 | 0.16% | ||
| 44 | Swiss National Bank | 32,900 | 669,000 | 0.16% | ||
| 45 | UNITED CAPITAL FINANCIAL ADVISORS, LLC | 32,740 | 666,000 | 0.16% | ||
| 46 | JANE STREET GROUP, LLC | 31,300 | 636,000 | 0.15% | Call | |
| 47 | DEERE & CO | 31,175 | 634,000 | 0.15% | ||
| 48 | Rotella Capital Management, Inc. | 27,600 | 561,000 | 0.14% | ||
| 49 | Virtu KCG Holdings LLC | 27,151 | 552,000 | 0.13% | ||
| 50 | RHUMBLINE ADVISERS | 25,940 | 527,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
