| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,939,366 | 53,632,000 | 28.57% | ||
| 2 | FMR LLC | 2,827,799 | 25,535,000 | 13.60% | ||
| 3 | SECTORAL ASSET MANAGEMENT INC | 2,174,015 | 19,631,000 | 10.46% | ||
| 4 | Broadfin Capital, LLC | 1,690,517 | 15,265,000 | 8.13% | ||
| 5 | VANGUARD GROUP INC | 1,251,182 | 11,298,000 | 6.02% | ||
| 6 | Cormorant Asset Management, LP | 800,000 | 7,224,000 | 3.85% | ||
| 7 | BlackRock Fund Advisors | 790,604 | 7,139,000 | 3.80% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 713,611 | 6,444,000 | 3.43% | ||
| 9 | ORBIMED ADVISORS LLC | 636,600 | 5,748,000 | 3.06% | ||
| 10 | STATE STREET CORP | 500,042 | 4,517,000 | 2.41% | ||
| 11 | NORTHERN TRUST CORP | 355,050 | 3,206,000 | 1.71% | ||
| 12 | GEODE CAPITAL MANAGEMENT, LLC | 183,611 | 1,658,000 | 0.88% | ||
| 13 | Bank of New York Mellon Corp | 148,825 | 1,344,000 | 0.72% | ||
| 14 | FRANKLIN STREET ADVISORS INC /NC | 140,000 | 1,264,000 | 0.67% | ||
| 15 | Jefferies Group LLC | 137,200 | 1,239,000 | 0.66% | Call | |
| 16 | CREDIT SUISSE AG/ | 126,352 | 1,142,000 | 0.61% | ||
| 17 | Jefferies Group LLC | 122,473 | 1,106,000 | 0.59% | ||
| 18 | Allianz Asset Management GmbH | 115,768 | 1,045,000 | 0.56% | ||
| 19 | BlackRock Investment Management, LLC | 110,254 | 996,000 | 0.53% | ||
| 20 | PICTET ASSET MANAGEMENT LTD | 169,500 | 926,000 | 0.49% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 102,400 | 925,000 | 0.49% | Call | |
| 22 | NEXTHERA CAPITAL LP | 100,000 | 903,000 | 0.48% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 95,956 | 866,000 | 0.46% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 77,500 | 700,000 | 0.37% | Put | |
| 25 | CITADEL ADVISORS LLC | 76,401 | 690,000 | 0.37% | ||
| 26 | D.A. DAVIDSON & CO. | 72,500 | 654,000 | 0.35% | ||
| 27 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 64,252 | 580,000 | 0.31% | ||
| 28 | Squarepoint Ops LLC | 63,100 | 570,000 | 0.30% | ||
| 29 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 58,100 | 525,000 | 0.28% | ||
| 30 | TEACHERS ADVISORS, LLC | 57,059 | 515,000 | 0.27% | ||
| 31 | Weiss Multi-Strategy Advisers LLC | 56,000 | 506,000 | 0.27% | ||
| 32 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 53,950 | 487,000 | 0.26% | ||
| 33 | Swiss National Bank | 48,200 | 420,000 | 0.22% | ||
| 34 | BANK OF MONTREAL /CAN/ | 44,596 | 403,000 | 0.21% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 44,111 | 399,000 | 0.21% | ||
| 36 | D. E. Shaw & Co., Inc. | 42,380 | 383,000 | 0.20% | ||
| 37 | MORGAN STANLEY | 41,760 | 378,000 | 0.20% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 41,369 | 374,000 | 0.20% | ||
| 39 | ALLIANCEBERNSTEIN L.P. | 38,100 | 344,000 | 0.18% | ||
| 40 | Birchview Capital, LP | 35,600 | 321,000 | 0.17% | ||
| 41 | UNITED CAPITAL FINANCIAL ADVISORS, LLC | 32,740 | 296,000 | 0.16% | ||
| 42 | VIRTUS ETF ADVISERS LLC | 31,328 | 283,000 | 0.15% | ||
| 43 | NEW YORK STATE COMMON RETIREMENT FUND | 30,200 | 273,000 | 0.15% | ||
| 44 | BlackRock Group LTD | 29,661 | 268,000 | 0.14% | ||
| 45 | CITIGROUP INC | 29,418 | 266,000 | 0.14% | ||
| 46 | Creative Planning | 29,280 | 264,000 | 0.14% | ||
| 47 | RHUMBLINE ADVISERS | 28,880 | 261,000 | 0.14% | ||
| 48 | WELLS FARGO & COMPANY/MN | 27,584 | 250,000 | 0.13% | ||
| 49 | JANE STREET GROUP, LLC | 26,900 | 243,000 | 0.13% | Call | |
| 50 | CITIGROUP INC | 24,400 | 220,000 | 0.12% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
