| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,939,366 | 48,049,000 | 26.17% | ||
| 2 | FMR LLC | 2,827,799 | 22,877,000 | 12.46% | ||
| 3 | Broadfin Capital, LLC | 1,690,517 | 13,676,000 | 7.45% | ||
| 4 | PICTET ASSET MANAGEMENT LTD | 1,428,619 | 13,229,000 | 7.20% | ||
| 5 | VANGUARD GROUP INC | 1,326,913 | 10,735,000 | 5.85% | ||
| 6 | BlackRock Fund Advisors | 869,989 | 7,038,000 | 3.83% | ||
| 7 | Cormorant Asset Management, LP | 809,804 | 6,551,000 | 3.57% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 728,300 | 5,892,000 | 3.21% | ||
| 9 | Sarissa Capital Management LP | 600,000 | 4,853,000 | 2.64% | ||
| 10 | STATE STREET CORP | 501,235 | 4,052,000 | 2.21% | ||
| 11 | ORBIMED ADVISORS LLC | 445,400 | 3,603,000 | 1.96% | ||
| 12 | SECTORAL ASSET MANAGEMENT INC | 433,859 | 3,510,000 | 1.91% | ||
| 13 | NORTHERN TRUST CORP | 386,249 | 3,125,000 | 1.70% | ||
| 14 | MARSHALL WACE, LLP | 273,597 | 2,213,000 | 1.21% | ||
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 193,700 | 1,567,000 | 0.85% | Call | |
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 188,818 | 1,527,000 | 0.83% | ||
| 17 | Allianz Asset Management GmbH | 185,813 | 1,503,000 | 0.82% | ||
| 18 | MONASHEE INVESTMENT MANAGEMENT LLC | 170,611 | 1,380,000 | 0.75% | PRN | |
| 19 | Bank of New York Mellon Corp | 164,368 | 1,330,000 | 0.72% | ||
| 20 | GRATICULE ASIA MACRO ADVISORS LLC | 160,000 | 1,294,000 | 0.70% | ||
| 21 | Jefferies Group LLC | 151,672 | 1,227,000 | 0.67% | ||
| 22 | CREDIT SUISSE AG/ | 148,536 | 1,200,000 | 0.65% | ||
| 23 | FRANKLIN STREET ADVISORS INC /NC | 136,350 | 1,103,000 | 0.60% | ||
| 24 | BlackRock Investment Management, LLC | 126,544 | 1,024,000 | 0.56% | ||
| 25 | THRIVENT FINANCIAL FOR LUTHERANS | 125,900 | 1,018,000 | 0.55% | ||
| 26 | NEXTHERA CAPITAL LP | 125,000 | 1,011,000 | 0.55% | ||
| 27 | D. E. Shaw & Co., Inc. | 123,726 | 1,001,000 | 0.55% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 106,000 | 858,000 | 0.47% | Put | |
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 102,545 | 830,000 | 0.45% | ||
| 30 | EcoR1 Capital, LLC | 92,800 | 751,000 | 0.41% | ||
| 31 | CITADEL ADVISORS LLC | 86,115 | 697,000 | 0.38% | ||
| 32 | Vident Investment Advisory, LLC | 79,843 | 646,000 | 0.35% | ||
| 33 | BANK OF MONTREAL /CAN/ | 77,807 | 629,000 | 0.34% | ||
| 34 | D.A. DAVIDSON & CO. | 75,000 | 606,000 | 0.33% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 70,041 | 567,000 | 0.31% | ||
| 36 | EMERALD ACQUISITION LTD. | 65,338 | 529,000 | 0.29% | ||
| 37 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 62,424 | 505,000 | 0.28% | ||
| 38 | TEACHERS ADVISORS, LLC | 58,061 | 470,000 | 0.26% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 56,679 | 459,000 | 0.25% | ||
| 40 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 56,300 | 456,000 | 0.25% | ||
| 41 | ALLIANCEBERNSTEIN L.P. | 54,100 | 438,000 | 0.24% | ||
| 42 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 53,950 | 436,000 | 0.24% | ||
| 43 | Swiss National Bank | 53,500 | 433,000 | 0.24% | ||
| 44 | MORGAN STANLEY | 52,383 | 423,000 | 0.23% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 44,111 | 357,000 | 0.19% | ||
| 46 | Weiss Multi-Strategy Advisers LLC | 41,553 | 336,000 | 0.18% | ||
| 47 | RHUMBLINE ADVISERS | 39,105 | 316,000 | 0.17% | ||
| 48 | Jefferies Group LLC | 36,900 | 299,000 | 0.16% | Call | |
| 49 | Birchview Capital, LP | 35,600 | 288,000 | 0.16% | ||
| 50 | CITIGROUP INC | 34,400 | 278,000 | 0.15% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
