| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,939,366 | 63,492,000 | 25.21% | ||
| 2 | FMR LLC | 4,130,585 | 44,156,000 | 17.53% | ||
| 3 | Broadfin Capital, LLC | 1,564,679 | 16,726,000 | 6.64% | ||
| 4 | VANGUARD GROUP INC | 1,472,352 | 15,739,000 | 6.25% | ||
| 5 | BlackRock Fund Advisors | 991,597 | 10,600,000 | 4.21% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 932,390 | 9,967,000 | 3.96% | ||
| 7 | Cormorant Asset Management, LP | 920,915 | 9,845,000 | 3.91% | ||
| 8 | Sarissa Capital Management LP | 600,000 | 6,413,000 | 2.55% | ||
| 9 | MARSHALL WACE, LLP | 559,578 | 5,982,000 | 2.37% | ||
| 10 | STATE STREET CORP | 521,179 | 5,569,000 | 2.21% | ||
| 11 | SECTORAL ASSET MANAGEMENT INC | 436,659 | 4,668,000 | 1.85% | ||
| 12 | NORTHERN TRUST CORP | 416,655 | 4,454,000 | 1.77% | ||
| 13 | Informed Momentum Co LLC | 379,731 | 4,059,000 | 1.61% | ||
| 14 | GEODE CAPITAL MANAGEMENT, LLC | 259,228 | 2,771,000 | 1.10% | ||
| 15 | Bank of New York Mellon Corp | 220,691 | 2,359,000 | 0.94% | ||
| 16 | NEXTHERA CAPITAL LP | 200,000 | 2,138,000 | 0.85% | ||
| 17 | SPHERA FUNDS MANAGEMENT LTD. | 200,000 | 2,138,000 | 0.85% | ||
| 18 | Jefferies Group LLC | 183,215 | 1,959,000 | 0.78% | ||
| 19 | Allianz Asset Management GmbH | 171,704 | 1,836,000 | 0.73% | ||
| 20 | BlackRock Investment Management, LLC | 141,709 | 1,515,000 | 0.60% | ||
| 21 | CITADEL ADVISORS LLC | 139,416 | 1,490,000 | 0.59% | ||
| 22 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 138,609 | 1,482,000 | 0.59% | ||
| 23 | Jefferies Group LLC | 132,300 | 1,414,000 | 0.56% | Call | |
| 24 | THRIVENT FINANCIAL FOR LUTHERANS | 125,900 | 1,346,000 | 0.53% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 120,700 | 1,290,000 | 0.51% | Call | |
| 26 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 114,529 | 1,225,000 | 0.49% | ||
| 27 | GRATICULE ASIA MACRO ADVISORS LLC | 107,500 | 1,149,000 | 0.46% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 105,400 | 1,127,000 | 0.45% | Put | |
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 104,102 | 1,113,000 | 0.44% | ||
| 30 | TANAKA CAPITAL MANAGEMENT INC | 103,600 | 1,107,000 | 0.44% | ||
| 31 | MORGAN STANLEY | 100,986 | 1,079,000 | 0.43% | ||
| 32 | EMERALD ACQUISITION LTD. | 97,897 | 1,046,000 | 0.42% | ||
| 33 | CREDIT SUISSE AG/ | 94,607 | 1,012,000 | 0.40% | ||
| 34 | AMERIPRISE FINANCIAL INC | 94,115 | 1,006,000 | 0.40% | ||
| 35 | FRANKLIN STREET ADVISORS INC /NC | 91,200 | 975,000 | 0.39% | ||
| 36 | Vident Investment Advisory, LLC | 80,825 | 864,000 | 0.34% | ||
| 37 | BANK OF MONTREAL /CAN/ | 79,542 | 850,000 | 0.34% | ||
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 75,841 | 811,000 | 0.32% | ||
| 39 | Jefferies Group LLC | 74,800 | 800,000 | 0.32% | Put | |
| 40 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 71,300 | 762,000 | 0.30% | ||
| 41 | TEACHERS ADVISORS, LLC | 60,394 | 646,000 | 0.26% | ||
| 42 | ALLIANCEBERNSTEIN L.P. | 54,100 | 578,000 | 0.23% | ||
| 43 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 52,500 | 561,000 | 0.22% | ||
| 44 | Swiss National Bank | 47,500 | 508,000 | 0.20% | ||
| 45 | CITIGROUP INC | 45,039 | 482,000 | 0.19% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 43,179 | 462,000 | 0.18% | ||
| 47 | CITIGROUP INC | 41,700 | 446,000 | 0.18% | Put | |
| 48 | Weiss Multi-Strategy Advisers LLC | 40,000 | 428,000 | 0.17% | ||
| 49 | RHUMBLINE ADVISERS | 39,745 | 425,000 | 0.17% | ||
| 50 | SG Americas Securities, LLC | 39,079 | 418,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
