| 1 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
4,454,604 |
35,681,000 |
48.29% |
|
|
| 2 |
PRICE T ROWE ASSOCIATES INC /MD/ |
1,217,781 |
9,754,000 |
13.20% |
|
|
| 3 |
Cormorant Asset Management, LP |
839,500 |
6,724,000 |
9.10% |
|
|
| 4 |
VANGUARD GROUP INC |
486,275 |
3,895,000 |
5.27% |
|
|
| 5 |
Ghost Tree Capital, LLC |
423,100 |
3,389,000 |
4.59% |
|
|
| 6 |
CITY NATIONAL BANK |
250,622 |
2,008,000 |
2.72% |
|
|
| 7 |
Rock Springs Capital Management LP |
225,000 |
1,802,000 |
2.44% |
|
|
| 8 |
SECTORAL ASSET MANAGEMENT INC |
210,850 |
1,689,000 |
2.29% |
|
|
| 9 |
Informed Momentum Co LLC |
192,192 |
1,539,000 |
2.08% |
|
|
| 10 |
BOGLE INVESTMENT MANAGEMENT L P /DE/ |
126,970 |
1,017,000 |
1.38% |
|
|
| 11 |
GEODE CAPITAL MANAGEMENT, LLC |
84,161 |
674,000 |
0.91% |
|
|
| 12 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
81,256 |
651,000 |
0.88% |
|
|
| 13 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
61,700 |
610,000 |
0.83% |
|
|
| 14 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
67,500 |
541,000 |
0.73% |
Put |
|
| 15 |
BlackRock Fund Advisors |
57,752 |
463,000 |
0.63% |
|
|
| 16 |
FRANKLIN STREET ADVISORS INC /NC |
55,000 |
440,000 |
0.60% |
|
|
| 17 |
D.A. DAVIDSON & CO. |
54,000 |
432,000 |
0.58% |
|
|
| 18 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
52,100 |
417,000 |
0.56% |
Call |
|
| 19 |
Creative Planning |
50,000 |
401,000 |
0.54% |
|
|
| 20 |
TD ASSET MANAGEMENT INC |
49,479 |
396,000 |
0.54% |
|
|
| 21 |
NORTHERN TRUST CORP |
26,592 |
213,000 |
0.29% |
|
|
| 22 |
UNITED CAPITAL FINANCIAL ADVISORS, LLC |
24,187 |
194,000 |
0.26% |
|
|
| 23 |
Bank of New York Mellon Corp |
23,000 |
184,000 |
0.25% |
|
|
| 24 |
Sio Capital Management, LLC |
39,000 |
161,000 |
0.22% |
|
|
| 25 |
MORGAN STANLEY |
16,693 |
134,000 |
0.18% |
|
|
| 26 |
Koshinski Asset Management, Inc. |
11,850 |
95,000 |
0.13% |
|
|
| 27 |
WELLS FARGO & COMPANY/MN |
10,840 |
87,000 |
0.12% |
|
|
| 28 |
DEUTSCHE BANK AG\ |
10,000 |
80,000 |
0.11% |
|
|
| 29 |
DIMENSIONAL FUND ADVISORS LP |
6,664 |
53,000 |
0.07% |
|
|
| 30 |
BlackRock Institutional Trust Company, N.A. |
6,656 |
53,000 |
0.07% |
|
|
| 31 |
BLACKROCK ADVISORS LLC |
4,185 |
34,000 |
0.05% |
|
|
| 32 |
BlackRock Investment Management, LLC |
3,232 |
26,000 |
0.04% |
|
|
| 33 |
UBS Group AG |
2,000 |
16,000 |
0.02% |
Call |
|
| 34 |
PNC FINANCIAL SERVICES GROUP, INC. |
2,000 |
16,000 |
0.02% |
|
|
| 35 |
UBS Group AG |
1,320 |
11,000 |
0.01% |
|
|
| 36 |
BANK OF AMERICA CORP /DE/ |
800 |
6,000 |
0.01% |
|
|
| 37 |
CITADEL ADVISORS LLC |
553 |
4,000 |
0.01% |
|
|
