| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,939,366 | 60,760,000 | 23.14% | ||
| 2 | FMR LLC | 2,587,299 | 26,468,000 | 10.08% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,408,397 | 24,638,000 | 9.39% | ||
| 4 | Broadfin Capital, LLC | 1,736,834 | 17,768,000 | 6.77% | ||
| 5 | SECTORAL ASSET MANAGEMENT INC | 1,263,415 | 12,925,000 | 4.92% | ||
| 6 | VANGUARD GROUP INC | 1,057,938 | 10,823,000 | 4.12% | ||
| 7 | Tourbillon Capital Partners, L.P. | 1,023,502 | 10,470,000 | 3.99% | ||
| 8 | BlackRock Fund Advisors | 800,051 | 8,185,000 | 3.12% | ||
| 9 | Cormorant Asset Management, LP | 800,000 | 8,184,000 | 3.12% | ||
| 10 | Jefferies Group LLC | 704,200 | 7,204,000 | 2.74% | Put | |
| 11 | BlackRock Institutional Trust Company, N.A. | 702,178 | 7,183,000 | 2.74% | ||
| 12 | ORBIMED ADVISORS LLC | 636,600 | 6,512,000 | 2.48% | ||
| 13 | GRATICULE ASIA MACRO ADVISORS LLC | 432,873 | 4,428,000 | 1.69% | ||
| 14 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 404,100 | 4,134,000 | 1.57% | Call | |
| 15 | Jefferies Group LLC | 343,600 | 3,515,000 | 1.34% | Call | |
| 16 | NORTHERN TRUST CORP | 341,637 | 3,495,000 | 1.33% | ||
| 17 | Rock Springs Capital Management LP | 337,000 | 3,448,000 | 1.31% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 302,800 | 3,098,000 | 1.18% | Put | |
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 236,275 | 2,417,000 | 0.92% | ||
| 20 | Jefferies Group LLC | 212,803 | 2,177,000 | 0.83% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 177,715 | 1,818,000 | 0.69% | ||
| 22 | CREDIT SUISSE AG/ | 154,009 | 1,576,000 | 0.60% | ||
| 23 | FRANKLIN STREET ADVISORS INC /NC | 141,200 | 1,444,000 | 0.55% | ||
| 24 | Weiss Multi-Strategy Advisers LLC | 135,000 | 1,381,000 | 0.53% | ||
| 25 | PICTET ASSET MANAGEMENT LTD | 125,600 | 1,285,000 | 0.49% | ||
| 26 | Bank of New York Mellon Corp | 125,009 | 1,278,000 | 0.49% | ||
| 27 | TD ASSET MANAGEMENT INC | 110,958 | 1,135,000 | 0.43% | ||
| 28 | BlackRock Investment Management, LLC | 107,572 | 1,100,000 | 0.42% | ||
| 29 | Trexquant Investment LP | 106,215 | 1,086,000 | 0.41% | ||
| 30 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 103,500 | 1,059,000 | 0.40% | ||
| 31 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 103,350 | 1,057,000 | 0.40% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 100,555 | 1,029,000 | 0.39% | ||
| 33 | GOLDMAN SACHS GROUP INC | 89,307 | 914,000 | 0.35% | ||
| 34 | SABBY MANAGEMENT, LLC | 85,700 | 877,000 | 0.33% | ||
| 35 | Allianz Asset Management GmbH | 76,704 | 785,000 | 0.30% | ||
| 36 | Laurion Capital Management LP | 70,000 | 716,000 | 0.27% | Put | |
| 37 | D.A. DAVIDSON & CO. | 64,500 | 659,000 | 0.25% | ||
| 38 | SMITH ASSET MANAGEMENT GROUP LP | 61,020 | 624,000 | 0.24% | ||
| 39 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 55,157 | 564,000 | 0.21% | ||
| 40 | DEUTSCHE BANK AG\ | 55,153 | 563,000 | 0.21% | ||
| 41 | TEACHERS ADVISORS, LLC | 45,558 | 466,000 | 0.18% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 44,111 | 452,000 | 0.17% | ||
| 43 | AMERICAN INTERNATIONAL GROUP, INC. | 41,626 | 425,000 | 0.16% | ||
| 44 | D. E. Shaw & Co., Inc. | 40,000 | 409,000 | 0.16% | Put | |
| 45 | CITIGROUP INC | 39,798 | 407,000 | 0.16% | ||
| 46 | AQR CAPITAL MANAGEMENT LLC | 39,225 | 401,000 | 0.15% | ||
| 47 | ALLIANCEBERNSTEIN L.P. | 38,100 | 390,000 | 0.15% | ||
| 48 | Swiss National Bank | 38,100 | 390,000 | 0.15% | ||
| 49 | Birchview Capital, LP | 35,600 | 364,000 | 0.14% | ||
| 50 | JANE STREET GROUP, LLC | 34,000 | 348,000 | 0.13% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
