| 1 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
5,139,366 |
74,212,000 |
31.40% |
|
|
| 2 |
PRICE T ROWE ASSOCIATES INC /MD/ |
2,493,208 |
36,002,000 |
15.23% |
|
|
| 3 |
FMR LLC |
2,350,705 |
33,944,000 |
14.36% |
|
|
| 4 |
Cormorant Asset Management, LP |
975,375 |
14,084,000 |
5.96% |
|
|
| 5 |
Broadfin Capital, LLC |
805,994 |
11,639,000 |
4.92% |
|
|
| 6 |
VANGUARD GROUP INC |
694,148 |
10,023,000 |
4.24% |
|
|
| 7 |
Rock Springs Capital Management LP |
490,000 |
7,076,000 |
2.99% |
|
|
| 8 |
ORBIMED ADVISORS LLC |
430,100 |
6,211,000 |
2.63% |
|
|
| 9 |
CITY NATIONAL BANK |
342,862 |
4,951,000 |
2.09% |
|
|
| 10 |
EverPoint Asset Management, LLC |
296,809 |
4,286,000 |
1.81% |
|
|
| 11 |
Knoll Capital Management, LLC |
275,000 |
3,971,000 |
1.68% |
|
|
| 12 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
152,500 |
2,202,000 |
0.93% |
Put |
|
| 13 |
SECTORAL ASSET MANAGEMENT INC |
150,654 |
2,175,000 |
0.92% |
|
|
| 14 |
BlackRock Institutional Trust Company, N.A. |
145,158 |
2,096,000 |
0.89% |
|
|
| 15 |
MORGAN STANLEY |
143,235 |
2,069,000 |
0.88% |
|
|
| 16 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
140,200 |
2,024,000 |
0.86% |
Call |
|
| 17 |
Ghost Tree Capital, LLC |
125,000 |
1,805,000 |
0.76% |
|
|
| 18 |
FRANKLIN STREET ADVISORS INC /NC |
117,400 |
1,695,000 |
0.72% |
|
|
| 19 |
TD ASSET MANAGEMENT INC |
108,658 |
1,569,000 |
0.66% |
|
|
| 20 |
JENNISON ASSOCIATES LLC |
101,000 |
1,458,000 |
0.62% |
|
|
| 21 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
99,570 |
1,438,000 |
0.61% |
|
|
| 22 |
GEODE CAPITAL MANAGEMENT, LLC |
94,398 |
1,363,000 |
0.58% |
|
|
| 23 |
Weiss Multi-Strategy Advisers LLC |
75,000 |
1,083,000 |
0.46% |
|
|
| 24 |
D.A. DAVIDSON & CO. |
64,000 |
924,000 |
0.39% |
|
|
| 25 |
CREDIT SUISSE AG/ |
61,148 |
883,000 |
0.37% |
|
|
| 26 |
BlackRock Fund Advisors |
60,060 |
867,000 |
0.37% |
|
|
| 27 |
GOLDMAN SACHS GROUP INC |
42,731 |
617,000 |
0.26% |
|
|
| 28 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
61,700 |
610,000 |
0.26% |
|
|
| 29 |
AQR CAPITAL MANAGEMENT LLC |
38,300 |
553,000 |
0.23% |
|
|
| 30 |
UNITED CAPITAL FINANCIAL ADVISORS, LLC |
32,740 |
550,000 |
0.23% |
|
|
| 31 |
NORTHERN TRUST CORP |
37,864 |
547,000 |
0.23% |
|
|
| 32 |
Bank of New York Mellon Corp |
25,228 |
365,000 |
0.15% |
|
|
| 33 |
JANE STREET GROUP, LLC |
23,268 |
336,000 |
0.14% |
|
|
| 34 |
PNC FINANCIAL SERVICES GROUP, INC. |
23,000 |
333,000 |
0.14% |
|
|
| 35 |
Creative Planning |
22,000 |
318,000 |
0.13% |
|
|
| 36 |
BlueCrest Capital Management Ltd |
21,268 |
307,000 |
0.13% |
|
|
| 37 |
DIMENSIONAL FUND ADVISORS LP |
17,614 |
254,000 |
0.11% |
|
|
| 38 |
EAGLE GLOBAL ADVISORS LLC |
16,810 |
243,000 |
0.10% |
|
|
| 39 |
TWO SIGMA INVESTMENTS, LP |
16,290 |
235,000 |
0.10% |
|
|
| 40 |
WELLS FARGO & COMPANY/MN |
11,740 |
170,000 |
0.07% |
|
|
| 41 |
AMERICAN INTERNATIONAL GROUP, INC. |
10,900 |
157,396 |
0.07% |
|
|
| 42 |
ARDSLEY ADVISORY PARTNERS LP |
10,100 |
146,000 |
0.06% |
|
|
| 43 |
DEUTSCHE BANK AG\ |
10,000 |
144,000 |
0.06% |
|
|
| 44 |
BANK OF AMERICA CORP /DE/ |
6,373 |
92,000 |
0.04% |
|
|
| 45 |
BANK OF MONTREAL /CAN/ |
6,207 |
90,000 |
0.04% |
|
|
| 46 |
BlackRock Investment Management, LLC |
4,520 |
65,000 |
0.03% |
|
|
| 47 |
BLACKROCK ADVISORS LLC |
4,185 |
60,000 |
0.03% |
|
|
| 48 |
Cowen Prime Services LLC |
2,500 |
36,000 |
0.02% |
|
|
| 49 |
WOLVERINE ASSET MANAGEMENT LLC |
46 |
24,000 |
0.01% |
Call |
|
| 50 |
UBS Group AG |
1,160 |
17,000 |
0.01% |
|
|
