| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,939,366 | 42,526,000 | 24.50% | ||
| 2 | FMR LLC | 4,102,885 | 29,377,000 | 16.93% | ||
| 3 | VANGUARD GROUP INC | 1,523,300 | 10,907,000 | 6.28% | ||
| 4 | Broadfin Capital, LLC | 1,519,259 | 10,878,000 | 6.27% | ||
| 5 | BlackRock Fund Advisors | 1,152,657 | 8,253,000 | 4.76% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 944,052 | 6,759,000 | 3.89% | ||
| 7 | SECTORAL ASSET MANAGEMENT INC | 690,074 | 4,941,000 | 2.85% | ||
| 8 | MARSHALL WACE, LLP | 678,683 | 4,859,000 | 2.80% | ||
| 9 | STATE STREET CORP | 621,505 | 4,452,000 | 2.57% | ||
| 10 | Jefferies Group LLC | 550,900 | 3,944,000 | 2.27% | Call | |
| 11 | Sarissa Capital Management LP | 500,000 | 3,579,000 | 2.06% | ||
| 12 | Jefferies Group LLC | 492,800 | 3,528,000 | 2.03% | Put | |
| 13 | NORTHERN TRUST CORP | 433,897 | 3,107,000 | 1.79% | ||
| 14 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 310,900 | 2,226,000 | 1.28% | Put | |
| 15 | CREDIT SUISSE AG/ | 301,606 | 2,159,000 | 1.24% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 267,076 | 1,912,000 | 1.10% | ||
| 17 | Knoll Capital Management, LLC | 225,000 | 1,611,000 | 0.93% | ||
| 18 | CITADEL ADVISORS LLC | 204,697 | 1,465,000 | 0.84% | ||
| 19 | NEXTHERA CAPITAL LP | 200,000 | 1,432,000 | 0.83% | ||
| 20 | MORGAN STANLEY | 189,422 | 1,357,000 | 0.78% | ||
| 21 | Bank of New York Mellon Corp | 180,326 | 1,291,000 | 0.74% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 180,134 | 1,290,000 | 0.74% | ||
| 23 | DAFNA Capital Management LLC | 175,000 | 1,253,000 | 0.72% | ||
| 24 | Allianz Asset Management GmbH | 146,927 | 1,052,000 | 0.61% | ||
| 25 | BlackRock Investment Management, LLC | 141,941 | 1,016,000 | 0.59% | ||
| 26 | TANAKA CAPITAL MANAGEMENT INC | 138,928 | 995,000 | 0.57% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 128,798 | 922,000 | 0.53% | ||
| 28 | THRIVENT FINANCIAL FOR LUTHERANS | 125,900 | 901,000 | 0.52% | ||
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 121,151 | 868,000 | 0.50% | ||
| 30 | D. E. Shaw & Co., Inc. | 104,708 | 750,000 | 0.43% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 99,900 | 715,000 | 0.41% | Call | |
| 32 | Vident Investment Advisory, LLC | 90,785 | 650,000 | 0.37% | ||
| 33 | FRANKLIN STREET ADVISORS INC /NC | 87,800 | 629,000 | 0.36% | ||
| 34 | A.R.T. Advisors, LLC | 83,700 | 599,000 | 0.35% | ||
| 35 | MILLENNIUM MANAGEMENT LLC | 78,156 | 560,000 | 0.32% | ||
| 36 | D.A. DAVIDSON & CO. | 77,500 | 554,000 | 0.32% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 73,741 | 528,000 | 0.30% | ||
| 38 | TEACHERS ADVISORS, LLC | 63,296 | 453,000 | 0.26% | ||
| 39 | ALLIANCEBERNSTEIN L.P. | 54,100 | 387,000 | 0.22% | ||
| 40 | BANK OF MONTREAL /CAN/ | 45,410 | 377,000 | 0.22% | ||
| 41 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 50,000 | 358,000 | 0.21% | ||
| 42 | SG Americas Securities, LLC | 47,935 | 343,000 | 0.20% | ||
| 43 | Swiss National Bank | 47,500 | 340,000 | 0.20% | ||
| 44 | GOLDMAN SACHS GROUP INC | 47,381 | 339,000 | 0.20% | ||
| 45 | WELLS FARGO & COMPANY/MN | 43,309 | 310,000 | 0.18% | ||
| 46 | CITIGROUP INC | 41,800 | 299,000 | 0.17% | Call | |
| 47 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 40,027 | 287,000 | 0.17% | ||
| 48 | Weiss Multi-Strategy Advisers LLC | 40,000 | 286,000 | 0.16% | ||
| 49 | RHUMBLINE ADVISERS | 39,642 | 284,000 | 0.16% | ||
| 50 | PRICE T ROWE ASSOCIATES INC /MD/ | 38,200 | 274,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
