| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 10,934,154 | 153,844,000 | 48.96% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,376,330 | 47,505,000 | 15.12% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 1,396,071 | 19,643,000 | 6.25% | ||
| 4 | BlackRock Finance, Inc. | 1,347,116 | 18,954,000 | 6.03% | ||
| 5 | FRANKLIN RESOURCES INC | 1,320,245 | 18,576,000 | 5.91% | ||
| 6 | GOLDMAN SACHS GROUP INC | 962,896 | 13,548,000 | 4.31% | ||
| 7 | BOXER CAPITAL, LLC | 525,000 | 7,387,000 | 2.35% | ||
| 8 | Ghost Tree Capital, LLC | 300,000 | 4,221,000 | 1.34% | ||
| 9 | VANGUARD GROUP INC | 282,483 | 3,974,000 | 1.26% | ||
| 10 | Alyeska Investment Group, L.P. | 277,523 | 3,905,000 | 1.24% | ||
| 11 | ASCEND CAPITAL, LLC | 214,328 | 3,017,000 | 0.96% | ||
| 12 | EVENTIDE ASSET MANAGEMENT, LLC | 175,000 | 2,462,000 | 0.78% | ||
| 13 | UNIVERSITY OF NOTRE DAME DU LAC | 171,217 | 2,409,000 | 0.77% | ||
| 14 | ROYCE & ASSOCIATES LP | 145,397 | 2,046,000 | 0.65% | ||
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 122,220 | 1,719,000 | 0.55% | ||
| 16 | EMORY UNIVERSITY | 105,815 | 1,489,000 | 0.47% | ||
| 17 | NEXTHERA CAPITAL LP | 90,700 | 1,276,000 | 0.41% | ||
| 18 | TD ASSET MANAGEMENT INC | 84,644 | 1,191,000 | 0.38% | ||
| 19 | NORTHERN TRUST CORP | 83,207 | 1,171,000 | 0.37% | ||
| 20 | SPHERA FUNDS MANAGEMENT LTD. | 62,085 | 874,000 | 0.28% | ||
| 21 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 56,800 | 799,000 | 0.25% | ||
| 22 | Polar Capital LLP | 50,000 | 704,000 | 0.22% | ||
| 23 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,000 | 704,000 | 0.22% | ||
| 24 | DEUTSCHE BANK AG\ | 31,425 | 442,000 | 0.14% | ||
| 25 | Bank of New York Mellon Corp | 23,260 | 327,000 | 0.10% | ||
| 26 | VIRTUS ETF ADVISERS LLC | 21,686 | 305,000 | 0.10% | ||
| 27 | ALPS ADVISORS INC | 21,090 | 297,000 | 0.09% | ||
| 28 | Archon Partners LLC | 18,000 | 253,000 | 0.08% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 17,646 | 248,000 | 0.08% | ||
| 30 | MORGAN STANLEY | 14,315 | 202,000 | 0.06% | ||
| 31 | ProShare Advisors LLC | 12,024 | 169,000 | 0.05% | ||
| 32 | STATE STREET CORP | 11,700 | 164,000 | 0.05% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10,000 | 141,000 | 0.04% | Call | |
| 34 | D.A. DAVIDSON & CO. | 9,400 | 132,000 | 0.04% | ||
| 35 | BANK OF AMERICA CORP /DE/ | 5,096 | 72,000 | 0.02% | ||
| 36 | UBS Group AG | 1,653 | 23,000 | 0.01% | ||
| 37 | CITIGROUP INC | 990 | 14,000 | 0.00% | ||
| 38 | CUTLER GROUP LLC / CA | 370 | 5,000 | 0.00% | ||
| 39 | Tower Research Capital LLC (TRC) | 300 | 4,000 | 0.00% | ||
| 40 | BARCLAYS PLC | 200 | 3,000 | 0.00% | ||
| 41 | ADVISOR GROUP, INC. | 200 | 3,000 | 0.00% | ||
| 42 | CUTLER GROUP LLC / CA | 4,600 | 2,000 | 0.00% | Put | |
| 43 | CUTLER GROUP LLC / CA | 300 | 0 | 0.00% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
