| 1 |
FMR LLC |
2,598,664 |
48,725,000 |
41.26% |
|
|
| 2 |
Polaris Venture Management Co. V, L.L.C. |
2,128,678 |
39,913,000 |
33.80% |
|
|
| 3 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
483,219 |
9,060,000 |
7.67% |
|
|
| 4 |
WELLINGTON MANAGEMENT GROUP LLP |
291,829 |
5,472,000 |
4.63% |
|
|
| 5 |
AXA S.A. |
166,684 |
3,125,000 |
2.65% |
|
|
| 6 |
PRINCIPAL FINANCIAL GROUP INC |
121,412 |
2,276,000 |
1.93% |
|
|
| 7 |
BlackRock Fund Advisors |
97,542 |
1,829,000 |
1.55% |
|
|
| 8 |
VANGUARD GROUP INC |
90,697 |
1,701,000 |
1.44% |
|
|
| 9 |
BlackRock Institutional Trust Company, N.A. |
51,446 |
965,000 |
0.82% |
|
|
| 10 |
NORTHERN TRUST CORP |
43,804 |
822,000 |
0.70% |
|
|
| 11 |
GEODE CAPITAL MANAGEMENT, LLC |
33,670 |
631,000 |
0.53% |
|
|
| 12 |
STATE STREET CORP |
28,263 |
530,000 |
0.45% |
|
|
| 13 |
OPPENHEIMER & CO INC |
20,052 |
376,000 |
0.32% |
|
|
| 14 |
GOLDMAN SACHS GROUP INC |
17,281 |
324,000 |
0.27% |
|
|
| 15 |
Steinberg Global Asset Management |
15,850 |
297,000 |
0.25% |
|
|
| 16 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
15,363 |
288,000 |
0.24% |
|
|
| 17 |
Bank of New York Mellon Corp |
13,574 |
255,000 |
0.22% |
|
|
| 18 |
BlackRock Investment Management, LLC |
11,935 |
224,000 |
0.19% |
|
|
| 19 |
BANQUE PICTET & CIE SA |
11,606 |
218,000 |
0.18% |
|
|
| 20 |
A.R.T. Advisors, LLC |
11,069 |
207,000 |
0.18% |
|
|
| 21 |
WELLS FARGO & COMPANY/MN |
9,078 |
170,000 |
0.14% |
|
|
| 22 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
7,100 |
133,000 |
0.11% |
|
|
| 23 |
TEACHERS ADVISORS, LLC |
5,658 |
106,000 |
0.09% |
|
|
| 24 |
MORGAN STANLEY |
3,707 |
70,000 |
0.06% |
|
|
| 25 |
SCHRODER INVESTMENT MANAGEMENT GROUP |
3,500 |
65,625 |
0.06% |
|
|
| 26 |
PARADIGM ASSET MANAGEMENT CO LLC |
3,400 |
63,750 |
0.05% |
|
|
| 27 |
Nationwide Fund Advisors |
3,084 |
58,000 |
0.05% |
|
|
| 28 |
BLACKROCK ADVISORS LLC |
2,983 |
56,000 |
0.05% |
|
|
| 29 |
AMERICAN INTERNATIONAL GROUP, INC. |
2,555 |
47,906 |
0.04% |
|
|
| 30 |
BANK OF AMERICA CORP /DE/ |
1,288 |
24,000 |
0.02% |
|
|
| 31 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,150 |
22,000 |
0.02% |
|
|
| 32 |
ALLIANCEBERNSTEIN L.P. |
600 |
11,000 |
0.01% |
|
|
| 33 |
VIRTUS CAPITAL ADVISERS, LLC |
333 |
6,000 |
0.01% |
|
|
| 34 |
Ground Swell Capital, LLC |
297 |
6,000 |
0.01% |
|
|
| 35 |
BNP PARIBAS FINANCIAL MARKETS |
276 |
5,175 |
0.00% |
|
|
| 36 |
DEUTSCHE BANK AG\ |
239 |
4,000 |
0.00% |
|
|
| 37 |
CITIGROUP INC |
78 |
2,000 |
0.00% |
|
|
| 38 |
PNC FINANCIAL SERVICES GROUP, INC. |
100 |
2,000 |
0.00% |
|
|
| 39 |
BANK OF MONTREAL /CAN/ |
110 |
2,000 |
0.00% |
|
|
| 40 |
UBS AG |
69 |
1,000 |
0.00% |
|
|
| 41 |
BARCLAYS PLC |
63 |
1,000 |
0.00% |
|
|
