| 1 |
FMR LLC |
4,209,036 |
28,832,000 |
23.74% |
|
|
| 2 |
Polaris Venture Management Co. V, L.L.C. |
1,968,606 |
13,485,000 |
11.11% |
|
|
| 3 |
Broadfin Capital, LLC |
1,046,243 |
7,167,000 |
5.90% |
|
|
| 4 |
FRANKLIN RESOURCES INC |
1,025,000 |
7,021,000 |
5.78% |
|
|
| 5 |
SABBY MANAGEMENT, LLC |
729,141 |
4,995,000 |
4.11% |
|
|
| 6 |
Tourbillon Capital Partners, L.P. |
698,887 |
4,787,000 |
3.94% |
|
|
| 7 |
MILLENNIUM MANAGEMENT LLC |
676,833 |
4,636,000 |
3.82% |
|
|
| 8 |
Rock Springs Capital Management LP |
650,000 |
4,453,000 |
3.67% |
|
|
| 9 |
AXA S.A. |
599,312 |
4,105,000 |
3.38% |
|
|
| 10 |
BlackRock Fund Advisors |
563,492 |
3,860,000 |
3.18% |
|
|
| 11 |
VANGUARD GROUP INC |
520,188 |
3,563,000 |
2.93% |
|
|
| 12 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
501,257 |
3,434,000 |
2.83% |
|
|
| 13 |
AWM Investment Company, Inc. |
492,100 |
3,371,000 |
2.78% |
|
|
| 14 |
ALPS ADVISORS INC |
43,919 |
3,008,000 |
2.48% |
|
|
| 15 |
NORTHPOINTE CAPITAL LLC |
399,810 |
2,739,000 |
2.26% |
|
|
| 16 |
SPHERA FUNDS MANAGEMENT LTD. |
377,200 |
2,584,000 |
2.13% |
|
|
| 17 |
STATE STREET CORP |
251,404 |
1,724,000 |
1.42% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
232,350 |
1,592,000 |
1.31% |
|
|
| 19 |
Ghost Tree Capital, LLC |
220,000 |
1,507,000 |
1.24% |
|
|
| 20 |
PRINCIPAL FINANCIAL GROUP INC |
217,039 |
1,487,000 |
1.22% |
|
|
| 21 |
NORTHERN TRUST CORP |
215,247 |
1,475,000 |
1.21% |
|
|
| 22 |
MORGAN STANLEY |
210,275 |
1,440,000 |
1.19% |
|
|
| 23 |
Alyeska Investment Group, L.P. |
182,171 |
1,248,000 |
1.03% |
|
|
| 24 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
156,395 |
1,071,000 |
0.88% |
|
|
| 25 |
GEODE CAPITAL MANAGEMENT, LLC |
133,705 |
915,000 |
0.75% |
|
|
| 26 |
SMITH ASSET MANAGEMENT GROUP LP |
103,870 |
712,000 |
0.59% |
|
|
| 27 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
93,345 |
639,000 |
0.53% |
|
|
| 28 |
Redmile Group, LLC |
91,644 |
628,000 |
0.52% |
|
|
| 29 |
Bank of New York Mellon Corp |
73,118 |
500,000 |
0.41% |
|
|
| 30 |
BlackRock Investment Management, LLC |
71,309 |
488,000 |
0.40% |
|
|
| 31 |
Trexquant Investment LP |
65,269 |
447,000 |
0.37% |
|
|
| 32 |
Spark Investment Management LLC |
39,500 |
270,000 |
0.22% |
|
|
| 33 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
39,336 |
269,000 |
0.22% |
|
|
| 34 |
Connor, Clark & Lunn Investment Management Ltd. |
28,300 |
194,000 |
0.16% |
|
|
| 35 |
TFS CAPITAL LLC |
27,905 |
191,000 |
0.16% |
|
|
| 36 |
TEACHERS ADVISORS, LLC |
27,152 |
186,000 |
0.15% |
|
|
| 37 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
26,625 |
183,000 |
0.15% |
|
|
| 38 |
DEUTSCHE BANK AG\ |
25,981 |
177,000 |
0.15% |
|
|
| 39 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
25,000 |
171,000 |
0.14% |
|
|
| 40 |
NEW YORK STATE COMMON RETIREMENT FUND |
20,100 |
138,000 |
0.11% |
|
|
| 41 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
20,000 |
137,000 |
0.11% |
|
|
| 42 |
D. E. Shaw & Co., Inc. |
19,893 |
136,000 |
0.11% |
|
|
| 43 |
GOLDMAN SACHS GROUP INC |
18,895 |
129,000 |
0.11% |
|
|
| 44 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
18,018 |
124,000 |
0.10% |
|
|
| 45 |
RHUMBLINE ADVISERS |
16,519 |
113,000 |
0.09% |
|
|
| 46 |
METROPOLITAN LIFE INSURANCE CO/NY |
14,385 |
99,000 |
0.08% |
|
|
| 47 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
13,982 |
96,000 |
0.08% |
|
|
| 48 |
BLACKROCK ADVISORS LLC |
14,033 |
96,000 |
0.08% |
|
|
| 49 |
STEVENS CAPITAL MANAGEMENT LP |
12,515 |
86,000 |
0.07% |
|
|
| 50 |
Nationwide Fund Advisors |
12,338 |
85,000 |
0.07% |
|
|
