| 1 |
FMR LLC |
2,641,523 |
18,491,000 |
40.77% |
|
|
| 2 |
Polaris Venture Management Co. V, L.L.C. |
2,055,230 |
14,387,000 |
31.72% |
|
|
| 3 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
604,257 |
4,230,000 |
9.33% |
|
|
| 4 |
AXA S.A. |
237,941 |
1,666,000 |
3.67% |
|
|
| 5 |
WELLINGTON MANAGEMENT GROUP LLP |
218,575 |
1,530,000 |
3.37% |
|
|
| 6 |
PRINCIPAL FINANCIAL GROUP INC |
152,612 |
1,068,000 |
2.35% |
|
|
| 7 |
VANGUARD GROUP INC |
115,449 |
808,000 |
1.78% |
|
|
| 8 |
BlackRock Fund Advisors |
108,613 |
760,000 |
1.68% |
|
|
| 9 |
GEODE CAPITAL MANAGEMENT, LLC |
46,488 |
325,000 |
0.72% |
|
|
| 10 |
NORTHERN TRUST CORP |
45,386 |
318,000 |
0.70% |
|
|
| 11 |
BlackRock Institutional Trust Company, N.A. |
31,981 |
224,000 |
0.49% |
|
|
| 12 |
ARES MANAGEMENT LLC |
31,500 |
221,000 |
0.49% |
|
|
| 13 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
30,016 |
210,000 |
0.46% |
|
|
| 14 |
STATE STREET CORP |
29,935 |
208,000 |
0.46% |
|
|
| 15 |
Alyeska Investment Group, L.P. |
24,108 |
169,000 |
0.37% |
|
|
| 16 |
GOLDMAN SACHS GROUP INC |
20,828 |
146,000 |
0.32% |
|
|
| 17 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
14,580 |
102,000 |
0.22% |
|
|
| 18 |
Bank of New York Mellon Corp |
13,297 |
93,000 |
0.21% |
|
|
| 19 |
BlackRock Investment Management, LLC |
11,913 |
83,000 |
0.18% |
|
|
| 20 |
Steinberg Global Asset Management |
10,850 |
76,000 |
0.17% |
|
|
| 21 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
7,172 |
50,000 |
0.11% |
|
|
| 22 |
TEACHERS ADVISORS, LLC |
5,658 |
40,000 |
0.09% |
|
|
| 23 |
DEUTSCHE BANK AG\ |
4,866 |
34,000 |
0.07% |
|
|
| 24 |
SCHRODER INVESTMENT MANAGEMENT GROUP |
3,500 |
25,000 |
0.06% |
|
|
| 25 |
Nationwide Fund Advisors |
3,084 |
22,000 |
0.05% |
|
|
| 26 |
AMERICAN INTERNATIONAL GROUP, INC. |
2,457 |
17,199 |
0.04% |
|
|
| 27 |
BLACKROCK ADVISORS LLC |
1,630 |
11,000 |
0.02% |
|
|
| 28 |
UBS Group AG |
1,168 |
8,000 |
0.02% |
|
|
| 29 |
WELLS FARGO & COMPANY/MN |
1,181 |
8,000 |
0.02% |
|
|
| 30 |
MORGAN STANLEY |
996 |
7,000 |
0.02% |
|
|
| 31 |
CITIGROUP INC |
670 |
5,000 |
0.01% |
|
|
| 32 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
716 |
5,000 |
0.01% |
|
|
| 33 |
ALLIANCEBERNSTEIN L.P. |
300 |
2,000 |
0.00% |
|
|
| 34 |
BARCLAYS PLC |
317 |
2,000 |
0.00% |
|
|
| 35 |
Tower Research Capital LLC (TRC) |
340 |
2,000 |
0.00% |
|
|
| 36 |
BANK OF AMERICA CORP /DE/ |
200 |
1,000 |
0.00% |
|
|
| 37 |
BANK OF MONTREAL /CAN/ |
24 |
0 |
0.00% |
|
|
| 38 |
ROYAL BANK OF CANADA |
22 |
0 |
0.00% |
|
|
