| 1 |
FMR LLC |
3,622,432 |
49,736,000 |
27.33% |
|
|
| 2 |
Polaris Venture Management Co. V, L.L.C. |
1,968,606 |
27,029,000 |
14.85% |
|
|
| 3 |
Broadfin Capital, LLC |
996,760 |
13,686,000 |
7.52% |
|
|
| 4 |
FRANKLIN RESOURCES INC |
850,000 |
11,671,000 |
6.41% |
|
|
| 5 |
Redmile Group, LLC |
623,519 |
8,561,000 |
4.70% |
|
|
| 6 |
Tourbillon Capital Partners, L.P. |
595,403 |
8,175,000 |
4.49% |
|
|
| 7 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
564,257 |
7,747,000 |
4.26% |
|
|
| 8 |
AXA S.A. |
530,377 |
7,282,000 |
4.00% |
|
|
| 9 |
BlackRock Fund Advisors |
489,546 |
6,721,000 |
3.69% |
|
|
| 10 |
MILLENNIUM MANAGEMENT LLC |
445,022 |
6,110,000 |
3.36% |
|
|
| 11 |
VANGUARD GROUP INC |
323,337 |
4,439,000 |
2.44% |
|
|
| 12 |
SPHERA FUNDS MANAGEMENT LTD. |
302,200 |
4,149,000 |
2.28% |
|
|
| 13 |
Ghost Tree Capital, LLC |
270,000 |
3,707,000 |
2.04% |
|
|
| 14 |
PRINCIPAL FINANCIAL GROUP INC |
211,924 |
2,910,000 |
1.60% |
|
|
| 15 |
SABBY MANAGEMENT, LLC |
168,580 |
2,315,000 |
1.27% |
|
|
| 16 |
STATE STREET CORP |
155,895 |
2,140,000 |
1.18% |
|
|
| 17 |
BlackRock Institutional Trust Company, N.A. |
118,955 |
1,633,000 |
0.90% |
|
|
| 18 |
SMITH ASSET MANAGEMENT GROUP LP |
104,028 |
1,427,000 |
0.78% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
90,860 |
1,247,000 |
0.69% |
|
|
| 20 |
NORTHERN TRUST CORP |
71,968 |
988,000 |
0.54% |
|
|
| 21 |
Bank of New York Mellon Corp |
66,853 |
918,000 |
0.50% |
|
|
| 22 |
DEUTSCHE BANK AG\ |
64,786 |
889,000 |
0.49% |
|
|
| 23 |
BlackRock Investment Management, LLC |
64,471 |
885,000 |
0.49% |
|
|
| 24 |
MORGAN STANLEY |
62,556 |
859,000 |
0.47% |
|
|
| 25 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
60,954 |
837,000 |
0.46% |
|
|
| 26 |
TFS CAPITAL LLC |
43,276 |
594,000 |
0.33% |
|
|
| 27 |
RENAISSANCE TECHNOLOGIES LLC |
37,300 |
512,000 |
0.28% |
|
|
| 28 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
33,936 |
466,000 |
0.26% |
|
|
| 29 |
TEACHERS ADVISORS, LLC |
27,152 |
373,000 |
0.20% |
|
|
| 30 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
26,625 |
366,000 |
0.20% |
|
|
| 31 |
GOLDMAN SACHS GROUP INC |
26,581 |
365,000 |
0.20% |
|
|
| 32 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
25,000 |
343,000 |
0.19% |
|
|
| 33 |
ALPS ADVISORS INC |
23,939 |
329,000 |
0.18% |
|
|
| 34 |
Alyeska Investment Group, L.P. |
22,398 |
308,000 |
0.17% |
|
|
| 35 |
RHUMBLINE ADVISERS |
14,970 |
206,000 |
0.11% |
|
|
| 36 |
Spark Investment Management LLC |
14,700 |
201,000 |
0.11% |
|
|
| 37 |
METROPOLITAN LIFE INSURANCE CO/NY |
14,385 |
198,000 |
0.11% |
|
|
| 38 |
NEW YORK STATE COMMON RETIREMENT FUND |
12,923 |
177,000 |
0.10% |
|
|
| 39 |
CITIGROUP INC |
12,534 |
172,000 |
0.09% |
|
|
| 40 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
12,302 |
169,000 |
0.09% |
|
|
| 41 |
Nationwide Fund Advisors |
11,859 |
163,000 |
0.09% |
|
|
| 42 |
D. E. Shaw & Co., Inc. |
11,090 |
152,000 |
0.08% |
|
|
| 43 |
AMERICAN INTERNATIONAL GROUP, INC. |
10,888 |
149,492 |
0.08% |
|
|
| 44 |
VOYA INVESTMENT MANAGEMENT LLC |
10,254 |
141,000 |
0.08% |
|
|
| 45 |
BLACKROCK ADVISORS LLC |
10,058 |
138,000 |
0.08% |
|
|
| 46 |
GILDER GAGNON HOWE & CO LLC |
9,475 |
130,000 |
0.07% |
|
|
| 47 |
SCHRODER INVESTMENT MANAGEMENT GROUP |
3,500 |
45,000 |
0.02% |
|
|
| 48 |
UBS Group AG |
3,106 |
43,000 |
0.02% |
|
|
| 49 |
PANAGORA ASSET MANAGEMENT INC |
3,060 |
42,000 |
0.02% |
|
|
| 50 |
WELLS FARGO & COMPANY/MN |
2,930 |
40,000 |
0.02% |
|
|
