| 1 |
FMR LLC |
4,217,255 |
22,225,000 |
25.28% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
2,107,200 |
11,105,000 |
12.63% |
|
|
| 3 |
Polaris Venture Management Co. V, L.L.C. |
1,968,606 |
10,375,000 |
11.80% |
|
|
| 4 |
Broadfin Capital, LLC |
846,243 |
4,460,000 |
5.07% |
|
|
| 5 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
837,257 |
4,412,000 |
5.02% |
|
|
| 6 |
AWM Investment Company, Inc. |
715,000 |
3,768,000 |
4.29% |
|
|
| 7 |
VANGUARD GROUP INC |
591,811 |
3,119,000 |
3.55% |
|
|
| 8 |
AXA S.A. |
586,974 |
3,093,000 |
3.52% |
|
|
| 9 |
BlackRock Fund Advisors |
578,752 |
3,050,000 |
3.47% |
|
|
| 10 |
SPHERA FUNDS MANAGEMENT LTD. |
540,490 |
2,848,000 |
3.24% |
|
|
| 11 |
NORTHPOINTE CAPITAL LLC |
399,810 |
2,739,000 |
3.12% |
|
|
| 12 |
Rock Springs Capital Management LP |
480,000 |
2,530,000 |
2.88% |
|
|
| 13 |
BlackRock Institutional Trust Company, N.A. |
269,994 |
1,423,000 |
1.62% |
|
|
| 14 |
STATE STREET CORP |
260,100 |
1,370,000 |
1.56% |
|
|
| 15 |
PRINCIPAL FINANCIAL GROUP INC |
217,346 |
1,145,000 |
1.30% |
|
|
| 16 |
NORTHERN TRUST CORP |
217,188 |
1,145,000 |
1.30% |
|
|
| 17 |
Alyeska Investment Group, L.P. |
163,852 |
864,000 |
0.98% |
|
|
| 18 |
MILLENNIUM MANAGEMENT LLC |
163,105 |
860,000 |
0.98% |
|
|
| 19 |
SABBY MANAGEMENT, LLC |
156,134 |
823,000 |
0.94% |
|
|
| 20 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
138,988 |
732,000 |
0.83% |
|
|
| 21 |
JPMORGAN CHASE & CO |
136,700 |
720,000 |
0.82% |
|
|
| 22 |
GEODE CAPITAL MANAGEMENT, LLC |
135,247 |
712,000 |
0.81% |
|
|
| 23 |
Bank of New York Mellon Corp |
80,563 |
425,000 |
0.48% |
|
|
| 24 |
BlackRock Investment Management, LLC |
72,459 |
382,000 |
0.43% |
|
|
| 25 |
Trexquant Investment LP |
69,832 |
368,000 |
0.42% |
|
|
| 26 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
64,200 |
338,000 |
0.38% |
|
|
| 27 |
Connor, Clark & Lunn Investment Management Ltd. |
62,700 |
330,000 |
0.38% |
|
|
| 28 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
60,000 |
316,000 |
0.36% |
|
|
| 29 |
ROYCE & ASSOCIATES LP |
52,600 |
277,000 |
0.32% |
|
|
| 30 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
39,971 |
211,000 |
0.24% |
|
|
| 31 |
ALPS ADVISORS INC |
37,037 |
195,000 |
0.22% |
|
|
| 32 |
CREDIT SUISSE AG/ |
36,286 |
192,000 |
0.22% |
|
|
| 33 |
TEACHERS ADVISORS, LLC |
31,326 |
165,000 |
0.19% |
|
|
| 34 |
MORGAN STANLEY |
28,432 |
150,000 |
0.17% |
|
|
| 35 |
AQR CAPITAL MANAGEMENT LLC |
27,756 |
146,000 |
0.17% |
|
|
| 36 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
26,625 |
141,000 |
0.16% |
|
|
| 37 |
NEW YORK STATE COMMON RETIREMENT FUND |
20,100 |
106,000 |
0.12% |
|
|
| 38 |
RHUMBLINE ADVISERS |
19,934 |
105,000 |
0.12% |
|
|
| 39 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
13,982 |
74,000 |
0.08% |
|
|
| 40 |
Nationwide Fund Advisors |
13,828 |
73,000 |
0.08% |
|
|
| 41 |
BALYASNY ASSET MANAGEMENT L.P. |
11,100 |
58,000 |
0.07% |
|
|
| 42 |
AMERICAN INTERNATIONAL GROUP, INC. |
10,882 |
57,000 |
0.06% |
|
|
| 43 |
VOYA INVESTMENT MANAGEMENT LLC |
10,254 |
54,000 |
0.06% |
|
|
| 44 |
WELLS FARGO & COMPANY/MN |
10,010 |
52,000 |
0.06% |
|
|
| 45 |
BLACKROCK ADVISORS LLC |
9,322 |
49,000 |
0.06% |
|
|
| 46 |
CITIGROUP INC |
8,814 |
46,000 |
0.05% |
|
|
| 47 |
DEUTSCHE BANK AG\ |
5,355 |
27,000 |
0.03% |
|
|
| 48 |
BANK OF AMERICA CORP /DE/ |
2,622 |
14,000 |
0.02% |
|
|
| 49 |
BNP PARIBAS FINANCIAL MARKETS |
2,551 |
13,444 |
0.02% |
|
|
| 50 |
UBS Group AG |
1,800 |
9,000 |
0.01% |
|
|
