| 1 |
FMR LLC |
4,222,888 |
32,685,000 |
23.90% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
2,886,600 |
22,342,000 |
16.34% |
|
|
| 3 |
Polaris Venture Management Co. V, L.L.C. |
1,968,606 |
15,237,000 |
11.14% |
|
|
| 4 |
NORTHPOINTE CAPITAL LLC |
957,623 |
7,412,000 |
5.42% |
|
|
| 5 |
AWM Investment Company, Inc. |
865,000 |
6,695,000 |
4.90% |
|
|
| 6 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
787,257 |
6,093,000 |
4.46% |
|
|
| 7 |
VANGUARD GROUP INC |
599,453 |
4,640,000 |
3.39% |
|
|
| 8 |
AXA S.A. |
586,974 |
4,543,000 |
3.32% |
|
|
| 9 |
BlackRock Fund Advisors |
569,071 |
4,405,000 |
3.22% |
|
|
| 10 |
PERCEPTIVE ADVISORS LLC |
516,618 |
3,999,000 |
2.92% |
|
|
| 11 |
Rock Springs Capital Management LP |
480,000 |
3,715,000 |
2.72% |
|
|
| 12 |
SPHERA FUNDS MANAGEMENT LTD. |
361,908 |
2,801,000 |
2.05% |
|
|
| 13 |
STATE STREET CORP |
291,020 |
2,256,000 |
1.65% |
|
|
| 14 |
BlackRock Institutional Trust Company, N.A. |
266,867 |
2,066,000 |
1.51% |
|
|
| 15 |
AlphaMark Advisors, LLC |
226,740 |
1,755,000 |
1.28% |
|
|
| 16 |
NORTHERN TRUST CORP |
217,834 |
1,686,000 |
1.23% |
|
|
| 17 |
PRINCIPAL FINANCIAL GROUP INC |
215,223 |
1,666,000 |
1.22% |
|
|
| 18 |
Alyeska Investment Group, L.P. |
210,505 |
1,629,000 |
1.19% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
136,990 |
1,060,000 |
0.78% |
|
|
| 20 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
128,200 |
992,000 |
0.73% |
|
|
| 21 |
JPMORGAN CHASE & CO |
127,100 |
983,000 |
0.72% |
|
|
| 22 |
BOARDMAN BAY CAPITAL MANAGEMENT LLC |
93,468 |
723,000 |
0.53% |
|
|
| 23 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
85,493 |
662,000 |
0.48% |
|
|
| 24 |
BlackRock Investment Management, LLC |
74,139 |
574,000 |
0.42% |
|
|
| 25 |
SCHONFELD STRATEGIC ADVISORS LLC |
73,000 |
565,000 |
0.41% |
|
|
| 26 |
Bank of New York Mellon Corp |
68,342 |
529,000 |
0.39% |
|
|
| 27 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
64,090 |
496,000 |
0.36% |
|
|
| 28 |
OXFORD ASSET MANAGEMENT LLP |
60,225 |
466,000 |
0.34% |
|
|
| 29 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
60,000 |
464,000 |
0.34% |
|
|
| 30 |
Connor, Clark & Lunn Investment Management Ltd. |
56,725 |
439,000 |
0.32% |
|
|
| 31 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
45,876 |
355,000 |
0.26% |
|
|
| 32 |
Birchview Capital, LP |
39,000 |
302,000 |
0.22% |
|
|
| 33 |
ALPS ADVISORS INC |
31,661 |
245,000 |
0.18% |
|
|
| 34 |
TEACHERS ADVISORS, LLC |
31,326 |
242,000 |
0.18% |
|
|
| 35 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
26,625 |
207,000 |
0.15% |
|
|
| 36 |
MORGAN STANLEY |
26,485 |
205,000 |
0.15% |
|
|
| 37 |
CITIGROUP INC |
26,059 |
202,000 |
0.15% |
|
|
| 38 |
MILLENNIUM MANAGEMENT LLC |
20,818 |
161,000 |
0.12% |
|
|
| 39 |
NEW YORK STATE COMMON RETIREMENT FUND |
20,100 |
156,000 |
0.11% |
|
|
| 40 |
RHUMBLINE ADVISERS |
19,934 |
154,000 |
0.11% |
|
|
| 41 |
Nationwide Fund Advisors |
13,828 |
107,000 |
0.08% |
|
|
| 42 |
FNY Managed Accounts LLC |
13,750 |
106,425 |
0.08% |
|
|
| 43 |
GOLDMAN SACHS GROUP INC |
13,266 |
103,000 |
0.08% |
|
|
| 44 |
WELLS FARGO & COMPANY/MN |
11,112 |
87,000 |
0.06% |
|
|
| 45 |
AMERICAN INTERNATIONAL GROUP, INC. |
10,882 |
84,000 |
0.06% |
|
|
| 46 |
EAGLE GLOBAL ADVISORS LLC |
10,770 |
83,000 |
0.06% |
|
|
| 47 |
VOYA INVESTMENT MANAGEMENT LLC |
10,254 |
79,000 |
0.06% |
|
|
| 48 |
BLACKROCK ADVISORS LLC |
9,322 |
72,000 |
0.05% |
|
|
| 49 |
IFP ADVISORS, INC |
7,000 |
54,000 |
0.04% |
|
|
| 50 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
11,026 |
43,000 |
0.03% |
|
|
