| 1 |
FMR LLC |
3,496,040 |
41,463,000 |
29.07% |
|
|
| 2 |
Polaris Venture Management Co. V, L.L.C. |
2,055,230 |
24,375,000 |
17.09% |
|
|
| 3 |
Broadfin Capital, LLC |
1,035,000 |
12,275,000 |
8.61% |
|
|
| 4 |
FRANKLIN RESOURCES INC |
850,000 |
10,081,000 |
7.07% |
|
|
| 5 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
844,257 |
10,013,000 |
7.02% |
|
|
| 6 |
Redmile Group, LLC |
796,900 |
9,451,000 |
6.63% |
|
|
| 7 |
AXA S.A. |
530,377 |
6,290,000 |
4.41% |
|
|
| 8 |
Ghost Tree Capital, LLC |
420,000 |
4,981,000 |
3.49% |
|
|
| 9 |
Tourbillon Capital Partners, L.P. |
400,403 |
4,749,000 |
3.33% |
|
|
| 10 |
VANGUARD GROUP INC |
264,813 |
3,141,000 |
2.20% |
|
|
| 11 |
MILLENNIUM MANAGEMENT LLC |
198,092 |
2,349,000 |
1.65% |
|
|
| 12 |
PRINCIPAL FINANCIAL GROUP INC |
192,612 |
2,284,000 |
1.60% |
|
|
| 13 |
BlackRock Fund Advisors |
150,911 |
1,790,000 |
1.26% |
|
|
| 14 |
SPHERA FUNDS MANAGEMENT LTD. |
124,200 |
1,473,000 |
1.03% |
|
|
| 15 |
Alyeska Investment Group, L.P. |
101,020 |
1,198,000 |
0.84% |
|
|
| 16 |
SABBY MANAGEMENT, LLC |
100,000 |
1,186,000 |
0.83% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
79,641 |
944,000 |
0.66% |
|
|
| 18 |
NORTHERN TRUST CORP |
45,386 |
538,000 |
0.38% |
|
|
| 19 |
BlackRock Institutional Trust Company, N.A. |
41,140 |
488,000 |
0.34% |
|
|
| 20 |
STATE STREET CORP |
36,579 |
434,000 |
0.30% |
|
|
| 21 |
ARES MANAGEMENT LLC |
31,500 |
377,000 |
0.26% |
|
|
| 22 |
MORGAN STANLEY |
31,554 |
375,000 |
0.26% |
|
|
| 23 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
25,000 |
297,000 |
0.21% |
|
|
| 24 |
Bank of New York Mellon Corp |
22,773 |
270,000 |
0.19% |
|
|
| 25 |
GOLDMAN SACHS GROUP INC |
22,273 |
264,000 |
0.19% |
|
|
| 26 |
BlackRock Investment Management, LLC |
16,569 |
197,000 |
0.14% |
|
|
| 27 |
TFS CAPITAL LLC |
15,553 |
184,000 |
0.13% |
|
|
| 28 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
14,580 |
173,000 |
0.12% |
|
|
| 29 |
CREDIT SUISSE AG/ |
12,108 |
144,000 |
0.10% |
|
|
| 30 |
RENAISSANCE TECHNOLOGIES LLC |
10,500 |
125,000 |
0.09% |
|
|
| 31 |
ARDSLEY ADVISORY PARTNERS LP |
10,000 |
119,000 |
0.08% |
|
|
| 32 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
9,972 |
118,000 |
0.08% |
|
|
| 33 |
CITIGROUP INC |
8,713 |
104,000 |
0.07% |
|
|
| 34 |
TEACHERS ADVISORS, LLC |
5,658 |
67,000 |
0.05% |
|
|
| 35 |
BlackRock Group LTD |
4,905 |
58,000 |
0.04% |
|
|
| 36 |
SCHRODER INVESTMENT MANAGEMENT GROUP |
3,500 |
41,000 |
0.03% |
|
|
| 37 |
BLACKROCK ADVISORS LLC |
3,360 |
40,000 |
0.03% |
|
|
| 38 |
BlackRock Japan Co. Ltd |
3,414 |
40,000 |
0.03% |
|
|
| 39 |
Nationwide Fund Advisors |
3,084 |
37,000 |
0.03% |
|
|
| 40 |
AMERICAN INTERNATIONAL GROUP, INC. |
2,457 |
29,140 |
0.02% |
|
|
| 41 |
Tower Research Capital LLC (TRC) |
2,224 |
26,000 |
0.02% |
|
|
| 42 |
WELLS FARGO & COMPANY/MN |
1,223 |
15,000 |
0.01% |
|
|
| 43 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
716 |
8,000 |
0.01% |
|
|
| 44 |
ALLIANCEBERNSTEIN L.P. |
300 |
4,000 |
0.00% |
|
|
| 45 |
BNP PARIBAS FINANCIAL MARKETS |
96 |
1,139 |
0.00% |
|
|
| 46 |
BARCLAYS PLC |
135 |
1,000 |
0.00% |
|
|
| 47 |
BANK OF MONTREAL /CAN/ |
24 |
0 |
0.00% |
|
|
| 48 |
DEUTSCHE BANK AG\ |
1 |
0 |
0.00% |
|
|
