| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 5,122,539 | 149,475,000 | 14.26% | ||
| 2 | FMR LLC | 4,289,950 | 125,181,000 | 11.94% | ||
| 3 | Temasek Holdings (Private) Ltd | 4,233,568 | 123,536,000 | 11.78% | ||
| 4 | FRANKLIN RESOURCES INC | 1,635,701 | 47,730,000 | 4.55% | ||
| 5 | EAGLE ASSET MANAGEMENT INC | 1,618,521 | 47,228,000 | 4.50% | ||
| 6 | SECTORAL ASSET MANAGEMENT INC | 1,365,152 | 39,835,000 | 3.80% | ||
| 7 | ORBIMED ADVISORS LLC | 1,361,600 | 39,731,000 | 3.79% | ||
| 8 | VANGUARD GROUP INC | 1,341,579 | 39,147,000 | 3.73% | ||
| 9 | JPMORGAN CHASE & CO | 1,318,553 | 38,475,000 | 3.67% | ||
| 10 | BlackRock Fund Advisors | 1,299,323 | 37,914,000 | 3.62% | ||
| 11 | Abingworth LLP | 1,240,912 | 36,210,000 | 3.45% | ||
| 12 | MPM ASSET MANAGEMENT LLC | 1,220,672 | 35,619,000 | 3.40% | ||
| 13 | ONTARIO TEACHERS PENSION PLAN BOARD | 693,397 | 20,233,000 | 1.93% | ||
| 14 | JENNISON ASSOCIATES LLC | 641,046 | 18,706,000 | 1.78% | ||
| 15 | FRED ALGER MANAGEMENT, LLC | 621,890 | 18,147,000 | 1.73% | ||
| 16 | DEERFIELD MANAGEMENT COMPANY, L.P. | 584,848 | 17,066,000 | 1.63% | ||
| 17 | PRICE T ROWE ASSOCIATES INC /MD/ | 567,579 | 16,562,000 | 1.58% | ||
| 18 | STATE STREET CORP | 527,201 | 15,385,000 | 1.47% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 400,517 | 11,687,000 | 1.11% | ||
| 20 | EVENTIDE ASSET MANAGEMENT, LLC | 372,400 | 10,867,000 | 1.04% | ||
| 21 | Polar Capital LLP | 364,546 | 10,637,000 | 1.01% | ||
| 22 | ALLIANCEBERNSTEIN L.P. | 353,723 | 10,322,000 | 0.98% | ||
| 23 | EMERALD ADVISERS, LLC | 289,670 | 8,453,000 | 0.81% | ||
| 24 | AXA S.A. | 260,814 | 7,611,000 | 0.73% | ||
| 25 | Fernwood Investment Management, LLC | 224,911 | 6,563,000 | 0.63% | ||
| 26 | WELLS FARGO & COMPANY/MN | 223,682 | 6,527,000 | 0.62% | ||
| 27 | OppenheimerFunds, Inc. | 221,661 | 6,468,000 | 0.62% | ||
| 28 | EMERALD MUTUAL FUND ADVISERS TRUST | 201,021 | 5,866,000 | 0.56% | ||
| 29 | BBT Capital Management, LLC | 200,000 | 5,836,000 | 0.56% | ||
| 30 | Cormorant Asset Management, LP | 200,000 | 5,836,000 | 0.56% | ||
| 31 | PUTNAM INVESTMENTS LLC | 199,600 | 5,824,000 | 0.56% | ||
| 32 | Bank of New York Mellon Corp | 187,429 | 5,469,000 | 0.52% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 185,129 | 5,402,000 | 0.52% | ||
| 34 | CITADEL ADVISORS LLC | 185,007 | 5,398,000 | 0.51% | ||
| 35 | NORTHERN TRUST CORP | 165,086 | 4,817,000 | 0.46% | ||
| 36 | MILLENNIUM MANAGEMENT LLC | 163,578 | 4,773,000 | 0.46% | ||
| 37 | HARVEY CAPITAL MANAGEMENT INC | 107,030 | 3,123,000 | 0.30% | ||
| 38 | BlackRock Investment Management, LLC | 100,380 | 2,929,000 | 0.28% | ||
| 39 | MANAGED ACCOUNT ADVISORS LLC | 100,337 | 2,928,000 | 0.28% | ||
| 40 | PICTET ASSET MANAGEMENT LTD | 84,850 | 2,476,000 | 0.24% | ||
| 41 | GEODE CAPITAL MANAGEMENT, LLC | 79,844 | 2,329,000 | 0.22% | ||
| 42 | MASON STREET ADVISORS, LLC | 78,230 | 2,283,000 | 0.22% | ||
| 43 | TFS CAPITAL LLC | 77,071 | 2,249,000 | 0.21% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 67,379 | 1,966,000 | 0.19% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 61,535 | 1,796,000 | 0.17% | ||
| 46 | MACQUARIE GROUP LTD | 59,830 | 1,746,000 | 0.17% | ||
| 47 | PARADIGM ASSET MANAGEMENT CO LLC | 52,500 | 1,531,950 | 0.15% | ||
| 48 | MORGAN STANLEY | 52,407 | 1,529,000 | 0.15% | ||
| 49 | TEACHERS ADVISORS, LLC | 51,906 | 1,515,000 | 0.14% | ||
| 50 | JANE STREET GROUP, LLC | 51,418 | 1,500,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
