| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,191,430 | 235,027,000 | 12.92% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 6,073,581 | 230,553,000 | 12.68% | ||
| 3 | Temasek Holdings (Private) Ltd | 5,833,568 | 221,442,000 | 12.18% | ||
| 4 | VANGUARD GROUP INC | 2,433,271 | 92,367,000 | 5.08% | ||
| 5 | BlackRock Fund Advisors | 1,800,614 | 68,351,000 | 3.76% | ||
| 6 | FRANKLIN RESOURCES INC | 1,498,601 | 56,887,000 | 3.13% | ||
| 7 | EAGLE ASSET MANAGEMENT INC | 1,465,800 | 55,641,000 | 3.06% | ||
| 8 | STATE STREET CORP | 1,257,103 | 47,720,000 | 2.62% | ||
| 9 | MPM ASSET MANAGEMENT LLC | 1,220,672 | 46,337,000 | 2.55% | ||
| 10 | SECTORAL ASSET MANAGEMENT INC | 1,162,730 | 44,137,000 | 2.43% | ||
| 11 | SCOPIA CAPITAL MANAGEMENT LP | 980,700 | 37,227,000 | 2.05% | ||
| 12 | CITADEL ADVISORS LLC | 966,570 | 36,691,000 | 2.02% | ||
| 13 | JPMORGAN CHASE & CO | 947,338 | 35,960,000 | 1.98% | ||
| 14 | ORBIMED ADVISORS LLC | 850,700 | 32,293,000 | 1.78% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 829,359 | 31,482,000 | 1.73% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 707,669 | 26,863,000 | 1.48% | ||
| 17 | JENNISON ASSOCIATES LLC | 643,357 | 24,422,000 | 1.34% | ||
| 18 | DEERFIELD MANAGEMENT COMPANY, L.P. | 574,546 | 21,810,000 | 1.20% | ||
| 19 | Cormorant Asset Management, LP | 574,500 | 21,808,000 | 1.20% | ||
| 20 | Polar Capital LLP | 567,647 | 21,548,000 | 1.18% | ||
| 21 | NORTHERN TRUST CORP | 508,719 | 19,311,000 | 1.06% | ||
| 22 | FRED ALGER MANAGEMENT, LLC | 482,986 | 18,334,000 | 1.01% | ||
| 23 | EMERALD ADVISERS, LLC | 432,900 | 15,667,000 | 0.86% | ||
| 24 | PRICE T ROWE ASSOCIATES INC /MD/ | 409,079 | 15,529,000 | 0.85% | ||
| 25 | EVENTIDE ASSET MANAGEMENT, LLC | 405,300 | 15,385,000 | 0.85% | ||
| 26 | Tourbillon Capital Partners, L.P. | 400,000 | 15,184,000 | 0.84% | ||
| 27 | ONTARIO TEACHERS PENSION PLAN BOARD | 390,109 | 14,809,000 | 0.81% | ||
| 28 | PERCEPTIVE ADVISORS LLC | 355,000 | 13,476,000 | 0.74% | ||
| 29 | Abingworth LLP | 347,349 | 13,185,000 | 0.73% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 341,392 | 12,959,000 | 0.71% | ||
| 31 | EMERALD MUTUAL FUND ADVISERS TRUST | 356,983 | 12,919,000 | 0.71% | ||
| 32 | ALLIANCEBERNSTEIN L.P. | 330,623 | 12,550,000 | 0.69% | ||
| 33 | MARSHALL WACE, LLP | 297,219 | 11,282,000 | 0.62% | ||
| 34 | Bank of New York Mellon Corp | 250,318 | 9,502,000 | 0.52% | ||
| 35 | WELLS FARGO & COMPANY/MN | 244,452 | 9,279,000 | 0.51% | ||
| 36 | AXA S.A. | 239,891 | 9,106,000 | 0.50% | ||
| 37 | MORGAN STANLEY | 235,570 | 8,942,000 | 0.49% | ||
| 38 | DEUTSCHE BANK AG\ | 218,965 | 8,309,000 | 0.46% | ||
| 39 | Fernwood Investment Management, LLC | 212,211 | 8,056,000 | 0.44% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 202,962 | 7,704,000 | 0.42% | ||
| 41 | BBT Capital Management, LLC | 200,000 | 7,592,000 | 0.42% | ||
| 42 | PUTNAM INVESTMENTS LLC | 199,600 | 7,577,000 | 0.42% | ||
| 43 | TWO SIGMA INVESTMENTS, LP | 188,542 | 7,157,000 | 0.39% | ||
| 44 | Ghost Tree Capital, LLC | 180,000 | 6,833,000 | 0.38% | ||
| 45 | Candriam S.C.A. | 160,000 | 6,075,000 | 0.33% | ||
| 46 | GUGGENHEIM CAPITAL LLC | 150,710 | 5,721,000 | 0.31% | ||
| 47 | HARVEY CAPITAL MANAGEMENT INC | 149,680 | 5,681,000 | 0.31% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 145,900 | 5,539,000 | 0.30% | ||
| 49 | GILDER GAGNON HOWE & CO LLC | 141,313 | 5,364,000 | 0.29% | ||
| 50 | BlackRock Investment Management, LLC | 126,341 | 4,796,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
