| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Temasek Holdings (Private) Ltd | 5,833,568 | 165,207,000 | 13.10% | ||
| 2 | FMR LLC | 5,769,330 | 163,387,000 | 12.95% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 5,399,028 | 152,901,000 | 12.12% | ||
| 4 | VANGUARD GROUP INC | 2,120,467 | 60,052,000 | 4.76% | ||
| 5 | FRANKLIN RESOURCES INC | 1,686,827 | 47,771,000 | 3.79% | ||
| 6 | BlackRock Fund Advisors | 1,674,648 | 47,426,000 | 3.76% | ||
| 7 | EAGLE ASSET MANAGEMENT INC | 1,627,913 | 46,102,000 | 3.66% | ||
| 8 | STATE STREET CORP | 1,245,824 | 35,279,000 | 2.80% | ||
| 9 | MPM ASSET MANAGEMENT LLC | 1,220,672 | 34,569,000 | 2.74% | ||
| 10 | SECTORAL ASSET MANAGEMENT INC | 1,120,379 | 31,729,000 | 2.52% | ||
| 11 | JPMORGAN CHASE & CO | 1,074,210 | 30,422,000 | 2.41% | ||
| 12 | SCOPIA CAPITAL MANAGEMENT LP | 1,031,026 | 29,199,000 | 2.32% | ||
| 13 | Abingworth LLP | 930,682 | 26,357,000 | 2.09% | ||
| 14 | ORBIMED ADVISORS LLC | 850,700 | 24,092,000 | 1.91% | ||
| 15 | FRED ALGER MANAGEMENT, LLC | 728,609 | 20,634,000 | 1.64% | ||
| 16 | ONTARIO TEACHERS PENSION PLAN BOARD | 693,397 | 19,637,000 | 1.56% | ||
| 17 | CITADEL ADVISORS LLC | 675,972 | 19,143,000 | 1.52% | ||
| 18 | Polar Capital LLP | 659,929 | 18,689,000 | 1.48% | ||
| 19 | DEERFIELD MANAGEMENT COMPANY, L.P. | 655,559 | 18,565,000 | 1.47% | ||
| 20 | JENNISON ASSOCIATES LLC | 641,299 | 18,162,000 | 1.44% | ||
| 21 | Cormorant Asset Management, LP | 600,000 | 16,992,000 | 1.35% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 587,974 | 16,651,000 | 1.32% | ||
| 23 | NORTHERN TRUST CORP | 492,659 | 13,952,000 | 1.11% | ||
| 24 | PRICE T ROWE ASSOCIATES INC /MD/ | 429,975 | 12,177,000 | 0.97% | ||
| 25 | EMERALD ADVISERS, LLC | 392,749 | 11,123,000 | 0.88% | ||
| 26 | EVENTIDE ASSET MANAGEMENT, LLC | 372,400 | 10,546,000 | 0.84% | ||
| 27 | MILLENNIUM MANAGEMENT LLC | 362,791 | 10,274,000 | 0.81% | ||
| 28 | EMERALD MUTUAL FUND ADVISERS TRUST | 337,183 | 9,549,000 | 0.76% | ||
| 29 | ALLIANCEBERNSTEIN L.P. | 326,823 | 9,256,000 | 0.73% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 304,376 | 8,619,000 | 0.68% | ||
| 31 | WELLS FARGO & COMPANY/MN | 290,656 | 8,232,000 | 0.65% | ||
| 32 | AXA S.A. | 240,537 | 6,812,000 | 0.54% | ||
| 33 | Fernwood Investment Management, LLC | 236,911 | 6,709,000 | 0.53% | ||
| 34 | Bank of New York Mellon Corp | 223,795 | 6,338,000 | 0.50% | ||
| 35 | BBT Capital Management, LLC | 200,000 | 5,664,000 | 0.45% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 199,972 | 5,663,000 | 0.45% | ||
| 37 | PUTNAM INVESTMENTS LLC | 199,600 | 5,653,000 | 0.45% | ||
| 38 | PICTET ASSET MANAGEMENT LTD | 163,022 | 4,617,000 | 0.37% | ||
| 39 | DEUTSCHE BANK AG\ | 160,169 | 4,535,000 | 0.36% | ||
| 40 | Ghost Tree Capital, LLC | 150,000 | 4,248,000 | 0.34% | ||
| 41 | GUGGENHEIM CAPITAL LLC | 136,999 | 3,880,000 | 0.31% | ||
| 42 | HARVEY CAPITAL MANAGEMENT INC | 136,630 | 3,869,000 | 0.31% | ||
| 43 | BlackRock Investment Management, LLC | 115,987 | 3,285,000 | 0.26% | ||
| 44 | MORGAN STANLEY | 112,686 | 3,191,000 | 0.25% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 110,584 | 3,132,000 | 0.25% | ||
| 46 | Lombard Odier Asset Management (USA) Corp | 102,488 | 2,902,000 | 0.23% | ||
| 47 | MANAGED ACCOUNT ADVISORS LLC | 90,154 | 2,553,000 | 0.20% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 79,603 | 2,254,000 | 0.18% | ||
| 49 | MASON STREET ADVISORS, LLC | 78,230 | 2,215,000 | 0.18% | ||
| 50 | MAZAMA CAPITAL MANAGEMENT INC | 70,311 | 1,991,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
