| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Temasek Holdings (Private) Ltd | 6,583,568 | 147,735,000 | 13.06% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 5,602,255 | 125,714,000 | 11.11% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,654,447 | 104,446,000 | 9.23% | ||
| 4 | VANGUARD GROUP INC | 4,422,394 | 99,239,000 | 8.77% | ||
| 5 | FMR LLC | 3,696,249 | 82,944,000 | 7.33% | ||
| 6 | BlackRock Fund Advisors | 2,309,648 | 51,829,000 | 4.58% | ||
| 7 | STATE STREET CORP | 2,016,452 | 45,242,000 | 4.00% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 1,465,381 | 32,883,000 | 2.91% | ||
| 9 | SECTORAL ASSET MANAGEMENT INC | 1,419,404 | 31,851,000 | 2.81% | ||
| 10 | JPMORGAN CHASE & CO | 1,245,920 | 27,958,000 | 2.47% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 1,132,279 | 25,408,000 | 2.25% | ||
| 12 | MORGAN STANLEY | 1,120,962 | 25,155,000 | 2.22% | ||
| 13 | EMERALD ADVISERS, LLC | 686,051 | 15,395,000 | 1.36% | ||
| 14 | PICTET ASSET MANAGEMENT LTD | 674,752 | 15,141,000 | 1.34% | ||
| 15 | NORTHERN TRUST CORP | 602,341 | 13,517,000 | 1.19% | ||
| 16 | WEATHERBIE CAPITAL, LLC | 598,814 | 13,437,000 | 1.19% | ||
| 17 | PFM Health Sciences, LP | 578,150 | 12,974,000 | 1.15% | ||
| 18 | ORBIMED ADVISORS LLC | 551,500 | 12,376,000 | 1.09% | ||
| 19 | PINNACLE ASSOCIATES LTD | 550,416 | 12,351,000 | 1.09% | ||
| 20 | Cormorant Asset Management, LP | 537,000 | 12,050,000 | 1.06% | ||
| 21 | PEREGRINE CAPITAL MANAGEMENT INC /MN/ | 459,367 | 10,308,000 | 0.91% | ||
| 22 | NORGES BANK | 447,681 | 10,046,000 | 0.89% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 440,208 | 9,878,000 | 0.87% | ||
| 24 | VOYA INVESTMENT MANAGEMENT LLC | 421,559 | 9,460,000 | 0.84% | ||
| 25 | EMERALD MUTUAL FUND ADVISERS TRUST | 386,693 | 8,677,000 | 0.77% | ||
| 26 | ALLIANCEBERNSTEIN L.P. | 342,283 | 7,681,000 | 0.68% | ||
| 27 | DEUTSCHE BANK AG\ | 340,783 | 7,645,000 | 0.68% | ||
| 28 | CITADEL ADVISORS LLC | 332,797 | 7,468,000 | 0.66% | ||
| 29 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 302,722 | 6,793,000 | 0.60% | ||
| 30 | PRUDENTIAL FINANCIAL INC | 292,710 | 6,568,000 | 0.58% | ||
| 31 | UBS Group AG | 252,000 | 5,655,000 | 0.50% | Call | |
| 32 | Fernwood Investment Management, LLC | 240,352 | 5,393,000 | 0.48% | ||
| 33 | Bank of New York Mellon Corp | 232,512 | 5,218,000 | 0.46% | ||
| 34 | HARVEY CAPITAL MANAGEMENT INC | 232,230 | 5,211,000 | 0.46% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 215,251 | 4,830,000 | 0.43% | ||
| 36 | GAM Holding AG | 209,100 | 4,692,000 | 0.41% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 208,953 | 4,689,000 | 0.41% | ||
| 38 | STRS OHIO | 190,800 | 4,281,000 | 0.38% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 189,500 | 4,252,000 | 0.38% | Put | |
| 40 | BlackRock Investment Management, LLC | 184,753 | 4,146,000 | 0.37% | ||
| 41 | GOLDMAN SACHS GROUP INC | 166,806 | 3,743,000 | 0.33% | ||
| 42 | BANK OF AMERICA CORP /DE/ | 164,659 | 3,695,000 | 0.33% | ||
| 43 | CITIGROUP INC | 139,088 | 3,121,000 | 0.28% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 132,800 | 2,980,000 | 0.26% | Call | |
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 126,557 | 2,840,000 | 0.25% | ||
| 46 | Randolph Co Inc | 125,400 | 2,814,000 | 0.25% | ||
| 47 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 121,834 | 2,734,000 | 0.24% | ||
| 48 | Rhenman & Partners Asset Management AB | 120,805 | 2,711,000 | 0.24% | ||
| 49 | C WorldWide Group Holding A/S | 114,180 | 2,562,000 | 0.23% | ||
| 50 | CREDIT SUISSE AG/ | 105,343 | 2,363,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
