| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Temasek Holdings (Private) Ltd | 6,583,568 | 149,513,000 | 12.93% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 6,207,775 | 140,979,000 | 12.19% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 5,639,727 | 128,078,000 | 11.07% | ||
| 4 | FMR LLC | 3,829,815 | 86,975,000 | 7.52% | ||
| 5 | VANGUARD GROUP INC | 3,732,586 | 84,768,000 | 7.33% | ||
| 6 | BlackRock Fund Advisors | 2,058,331 | 46,745,000 | 4.04% | ||
| 7 | STATE STREET CORP | 1,982,425 | 45,014,000 | 3.89% | ||
| 8 | SECTORAL ASSET MANAGEMENT INC | 1,419,208 | 32,230,000 | 2.79% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,402,266 | 31,845,000 | 2.75% | ||
| 10 | JPMORGAN CHASE & CO | 1,264,155 | 28,709,000 | 2.48% | ||
| 11 | Redmile Group, LLC | 916,927 | 20,823,000 | 1.80% | ||
| 12 | GOLDMAN SACHS GROUP INC | 828,854 | 18,823,000 | 1.63% | ||
| 13 | EMERALD ADVISERS, LLC | 743,559 | 16,886,000 | 1.46% | ||
| 14 | EMERALD MUTUAL FUND ADVISERS TRUST | 735,535 | 16,704,000 | 1.44% | ||
| 15 | NORTHERN TRUST CORP | 596,622 | 13,550,000 | 1.17% | ||
| 16 | Cormorant Asset Management, LP | 596,000 | 13,535,000 | 1.17% | ||
| 17 | PICTET ASSET MANAGEMENT LTD | 586,155 | 13,312,000 | 1.15% | ||
| 18 | PINNACLE ASSOCIATES LTD | 580,936 | 13,193,000 | 1.14% | ||
| 19 | MILLENNIUM MANAGEMENT LLC | 515,756 | 11,713,000 | 1.01% | ||
| 20 | DEUTSCHE BANK AG\ | 476,494 | 10,819,000 | 0.94% | ||
| 21 | VOYA INVESTMENT MANAGEMENT LLC | 464,506 | 10,549,000 | 0.91% | ||
| 22 | PEREGRINE CAPITAL MANAGEMENT INC /MN/ | 451,568 | 10,255,000 | 0.89% | ||
| 23 | NORGES BANK | 447,681 | 9,710,000 | 0.84% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 413,001 | 9,379,000 | 0.81% | ||
| 25 | ORBIMED ADVISORS LLC | 370,900 | 8,423,000 | 0.73% | ||
| 26 | ALLIANCEBERNSTEIN L.P. | 342,283 | 7,773,000 | 0.67% | ||
| 27 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 317,616 | 7,213,000 | 0.62% | ||
| 28 | OXFORD ASSET MANAGEMENT LLP | 314,797 | 7,149,000 | 0.62% | ||
| 29 | UBS Group AG | 260,000 | 5,905,000 | 0.51% | Call | |
| 30 | MORGAN STANLEY | 254,915 | 5,789,000 | 0.50% | ||
| 31 | PRUDENTIAL FINANCIAL INC | 247,510 | 5,621,000 | 0.49% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 238,947 | 5,426,000 | 0.47% | ||
| 33 | Fernwood Investment Management, LLC | 236,752 | 5,377,000 | 0.46% | ||
| 34 | Bank of New York Mellon Corp | 222,903 | 5,062,000 | 0.44% | ||
| 35 | GAM Holding AG | 209,100 | 4,749,000 | 0.41% | ||
| 36 | STRS OHIO | 195,000 | 4,428,000 | 0.38% | ||
| 37 | Numeric Investors LLC | 194,700 | 4,422,000 | 0.38% | ||
| 38 | D. E. Shaw & Co., Inc. | 189,226 | 4,298,000 | 0.37% | ||
| 39 | BlackRock Investment Management, LLC | 185,301 | 4,208,000 | 0.36% | ||
| 40 | HARVEY CAPITAL MANAGEMENT INC | 184,130 | 4,181,000 | 0.36% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 178,782 | 4,061,000 | 0.35% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 177,300 | 4,026,000 | 0.35% | Put | |
| 43 | Invesco Ltd. | 172,240 | 3,912,000 | 0.34% | ||
| 44 | RENAISSANCE TECHNOLOGIES LLC | 161,500 | 3,668,000 | 0.32% | ||
| 45 | Rail-Splitter Capital Management, LLC | 160,229 | 3,639,000 | 0.31% | ||
| 46 | BANK OF AMERICA CORP /DE/ | 157,762 | 3,582,000 | 0.31% | ||
| 47 | SG Americas Securities, LLC | 145,355 | 3,301,000 | 0.29% | ||
| 48 | C WorldWide Group Holding A/S | 126,113 | 2,864,000 | 0.25% | ||
| 49 | Randolph Co Inc | 125,450 | 2,849,000 | 0.25% | ||
| 50 | LAZARD ASSET MANAGEMENT LLC | 122,300 | 2,777,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
