| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 5,473,939 | 141,774,000 | 16.44% | ||
| 2 | Temasek Holdings (Private) Ltd | 4,233,568 | 109,649,000 | 12.71% | ||
| 3 | FMR LLC | 3,380,900 | 87,565,000 | 10.15% | ||
| 4 | JPMORGAN CHASE & CO | 1,341,756 | 34,751,000 | 4.03% | ||
| 5 | VANGUARD GROUP INC | 1,268,019 | 32,842,000 | 3.81% | ||
| 6 | Abingworth LLP | 1,240,912 | 32,140,000 | 3.73% | ||
| 7 | MPM ASSET MANAGEMENT LLC | 1,220,672 | 31,615,000 | 3.67% | ||
| 8 | SECTORAL ASSET MANAGEMENT INC | 1,212,245 | 31,397,000 | 3.64% | ||
| 9 | EAGLE ASSET MANAGEMENT INC | 1,151,414 | 29,821,000 | 3.46% | ||
| 10 | FRANKLIN RESOURCES INC | 1,069,701 | 27,705,000 | 3.21% | ||
| 11 | ORBIMED ADVISORS LLC | 957,700 | 24,804,000 | 2.88% | ||
| 12 | FRED ALGER MANAGEMENT, LLC | 775,867 | 20,095,000 | 2.33% | ||
| 13 | DEERFIELD MANAGEMENT COMPANY, L.P. | 769,848 | 19,939,000 | 2.31% | ||
| 14 | BlackRock Fund Advisors | 756,237 | 19,587,000 | 2.27% | ||
| 15 | PRICE T ROWE ASSOCIATES INC /MD/ | 725,535 | 18,791,000 | 2.18% | ||
| 16 | JENNISON ASSOCIATES LLC | 717,216 | 18,576,000 | 2.15% | ||
| 17 | ONTARIO TEACHERS PENSION PLAN BOARD | 693,397 | 17,959,000 | 2.08% | ||
| 18 | Redmile Group, LLC | 452,194 | 11,712,000 | 1.36% | ||
| 19 | EVENTIDE ASSET MANAGEMENT, LLC | 363,500 | 9,415,000 | 1.09% | ||
| 20 | ALLIANCEBERNSTEIN L.P. | 339,357 | 8,789,000 | 1.02% | ||
| 21 | EMERALD ADVISERS, LLC | 291,201 | 7,542,000 | 0.87% | ||
| 22 | HAMILTON LANE ADVISORS LLC | 290,587 | 7,526,000 | 0.87% | ||
| 23 | AXA S.A. | 268,224 | 6,947,000 | 0.81% | ||
| 24 | BlackRock Institutional Trust Company, N.A. | 264,699 | 6,856,000 | 0.79% | ||
| 25 | Numeric Investors LLC | 233,786 | 6,055,000 | 0.70% | ||
| 26 | WELLS FARGO & COMPANY/MN | 228,085 | 5,908,000 | 0.68% | ||
| 27 | MILLENNIUM MANAGEMENT LLC | 206,587 | 5,351,000 | 0.62% | ||
| 28 | PUTNAM INVESTMENTS LLC | 200,400 | 5,190,000 | 0.60% | ||
| 29 | Cormorant Asset Management, LP | 200,000 | 5,180,000 | 0.60% | ||
| 30 | BBT Capital Management, LLC | 200,000 | 5,180,000 | 0.60% | ||
| 31 | EMERALD MUTUAL FUND ADVISERS TRUST | 197,550 | 5,117,000 | 0.59% | ||
| 32 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 182,685 | 4,732,000 | 0.55% | ||
| 33 | BAKER BROS. ADVISORS LP | 182,591 | 4,729,000 | 0.55% | ||
| 34 | NORTHERN TRUST CORP | 176,784 | 4,579,000 | 0.53% | ||
| 35 | STATE STREET CORP | 161,202 | 4,174,000 | 0.48% | ||
| 36 | MORGAN STANLEY | 139,514 | 3,614,000 | 0.42% | ||
| 37 | Fernwood Investment Management, LLC | 118,381 | 3,066,000 | 0.36% | ||
| 38 | MANAGED ACCOUNT ADVISORS LLC | 107,237 | 2,777,000 | 0.32% | ||
| 39 | HARVEY CAPITAL MANAGEMENT INC | 106,930 | 2,769,000 | 0.32% | ||
| 40 | Bank of New York Mellon Corp | 102,661 | 2,659,000 | 0.31% | ||
| 41 | BLACKROCK ADVISORS LLC | 100,611 | 2,606,000 | 0.30% | ||
| 42 | MASON STREET ADVISORS, LLC | 94,680 | 2,452,000 | 0.28% | ||
| 43 | NORGES BANK | 92,358 | 2,392,000 | 0.28% | ||
| 44 | Rail-Splitter Capital Management, LLC | 90,680 | 2,349,000 | 0.27% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 85,029 | 2,202,000 | 0.26% | ||
| 46 | PICTET ASSET MANAGEMENT LTD | 62,750 | 1,625,000 | 0.19% | ||
| 47 | GEODE CAPITAL MANAGEMENT, LLC | 60,331 | 1,562,000 | 0.18% | ||
| 48 | MACQUARIE GROUP LTD | 58,418 | 1,513,000 | 0.18% | ||
| 49 | TFS CAPITAL LLC | 41,586 | 1,077,000 | 0.12% | ||
| 50 | ProShare Advisors LLC | 41,443 | 1,073,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
