| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 4,999,252 | 126,381,000 | 13.46% | ||
| 2 | FMR LLC | 4,639,920 | 117,297,000 | 12.49% | ||
| 3 | Temasek Holdings (Private) Ltd | 4,233,568 | 107,025,000 | 11.40% | ||
| 4 | FRANKLIN RESOURCES INC | 1,794,801 | 45,373,000 | 4.83% | ||
| 5 | EAGLE ASSET MANAGEMENT INC | 1,729,458 | 43,720,000 | 4.66% | ||
| 6 | VANGUARD GROUP INC | 1,662,770 | 42,035,000 | 4.48% | ||
| 7 | SECTORAL ASSET MANAGEMENT INC | 1,412,350 | 35,704,000 | 3.80% | ||
| 8 | BlackRock Fund Advisors | 1,297,920 | 32,811,000 | 3.49% | ||
| 9 | JPMORGAN CHASE & CO | 1,229,596 | 31,085,000 | 3.31% | ||
| 10 | MPM ASSET MANAGEMENT LLC | 1,220,672 | 30,859,000 | 3.29% | ||
| 11 | Abingworth LLP | 930,682 | 23,528,000 | 2.51% | ||
| 12 | ORBIMED ADVISORS LLC | 850,700 | 21,506,000 | 2.29% | ||
| 13 | ONTARIO TEACHERS PENSION PLAN BOARD | 693,397 | 17,529,000 | 1.87% | ||
| 14 | JENNISON ASSOCIATES LLC | 642,005 | 16,230,000 | 1.73% | ||
| 15 | FRED ALGER MANAGEMENT, LLC | 619,452 | 15,660,000 | 1.67% | ||
| 16 | DEERFIELD MANAGEMENT COMPANY, L.P. | 557,477 | 14,093,000 | 1.50% | ||
| 17 | STATE STREET CORP | 556,535 | 14,071,000 | 1.50% | ||
| 18 | PRICE T ROWE ASSOCIATES INC /MD/ | 517,653 | 13,086,000 | 1.39% | ||
| 19 | Polar Capital LLP | 500,000 | 12,640,000 | 1.35% | ||
| 20 | MILLENNIUM MANAGEMENT LLC | 476,776 | 12,053,000 | 1.28% | ||
| 21 | NORTHERN TRUST CORP | 440,434 | 11,134,000 | 1.19% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 399,886 | 10,109,000 | 1.08% | ||
| 23 | EVENTIDE ASSET MANAGEMENT, LLC | 372,400 | 9,414,000 | 1.00% | ||
| 24 | ALLIANCEBERNSTEIN L.P. | 326,823 | 8,262,000 | 0.88% | ||
| 25 | EMERALD ADVISERS, LLC | 317,317 | 8,022,000 | 0.85% | ||
| 26 | EMERALD MUTUAL FUND ADVISERS TRUST | 284,211 | 7,185,000 | 0.77% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 265,765 | 6,718,000 | 0.72% | ||
| 28 | AXA S.A. | 259,150 | 6,551,000 | 0.70% | ||
| 29 | WELLS FARGO & COMPANY/MN | 245,318 | 6,202,000 | 0.66% | ||
| 30 | Fernwood Investment Management, LLC | 239,911 | 6,065,000 | 0.65% | ||
| 31 | Bank of New York Mellon Corp | 229,822 | 5,810,000 | 0.62% | ||
| 32 | BBT Capital Management, LLC | 200,000 | 5,056,000 | 0.54% | ||
| 33 | Cormorant Asset Management, LP | 200,000 | 5,056,000 | 0.54% | ||
| 34 | PUTNAM INVESTMENTS LLC | 199,600 | 5,046,000 | 0.54% | ||
| 35 | DEUTSCHE BANK AG\ | 190,290 | 4,808,000 | 0.51% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 189,915 | 4,801,000 | 0.51% | ||
| 37 | Point72 Asset Management, L.P. | 160,000 | 4,045,000 | 0.43% | ||
| 38 | EverPoint Asset Management, LLC | 150,000 | 3,792,000 | 0.40% | ||
| 39 | Ghost Tree Capital, LLC | 115,000 | 2,907,000 | 0.31% | ||
| 40 | HARVEY CAPITAL MANAGEMENT INC | 107,030 | 2,705,000 | 0.29% | ||
| 41 | BlackRock Investment Management, LLC | 100,666 | 2,545,000 | 0.27% | ||
| 42 | Numeric Investors LLC | 100,511 | 2,541,000 | 0.27% | ||
| 43 | MANAGED ACCOUNT ADVISORS LLC | 97,003 | 2,452,000 | 0.26% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 91,049 | 2,302,000 | 0.25% | ||
| 45 | PICTET ASSET MANAGEMENT LTD | 87,750 | 2,218,000 | 0.24% | ||
| 46 | MASON STREET ADVISORS, LLC | 78,230 | 1,978,000 | 0.21% | ||
| 47 | CITADEL ADVISORS LLC | 70,372 | 1,779,000 | 0.19% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 68,066 | 1,721,000 | 0.18% | ||
| 49 | MACQUARIE GROUP LTD | 60,183 | 1,521,000 | 0.16% | ||
| 50 | MORGAN STANLEY | 54,829 | 1,386,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
