| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 6,615,240 | 134,951,000 | 11.89% | ||
| 2 | Temasek Holdings (Private) Ltd | 6,583,568 | 134,305,000 | 11.83% | ||
| 3 | FMR LLC | 6,362,886 | 129,803,000 | 11.44% | ||
| 4 | VANGUARD GROUP INC | 3,491,453 | 71,226,000 | 6.28% | ||
| 5 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,089,785 | 63,032,000 | 5.55% | ||
| 6 | BlackRock Fund Advisors | 1,985,120 | 40,496,000 | 3.57% | ||
| 7 | STATE STREET CORP | 1,720,000 | 35,085,000 | 3.09% | ||
| 8 | SECTORAL ASSET MANAGEMENT INC | 1,593,039 | 32,498,000 | 2.86% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,487,058 | 30,336,000 | 2.67% | ||
| 10 | FRANKLIN RESOURCES INC | 1,315,812 | 26,842,000 | 2.36% | ||
| 11 | JPMORGAN CHASE & CO | 1,298,116 | 26,481,000 | 2.33% | ||
| 12 | Redmile Group, LLC | 889,607 | 18,148,000 | 1.60% | ||
| 13 | ORBIMED ADVISORS LLC | 838,100 | 17,097,000 | 1.51% | ||
| 14 | EAGLE ASSET MANAGEMENT INC | 700,947 | 14,299,000 | 1.26% | ||
| 15 | Cormorant Asset Management, LP | 700,000 | 14,280,000 | 1.26% | ||
| 16 | PRICE T ROWE ASSOCIATES INC /MD/ | 638,219 | 13,020,000 | 1.15% | ||
| 17 | NORTHERN TRUST CORP | 603,600 | 12,313,000 | 1.08% | ||
| 18 | Numeric Investors LLC | 585,556 | 11,945,000 | 1.05% | ||
| 19 | DEUTSCHE BANK AG\ | 509,087 | 10,383,000 | 0.91% | ||
| 20 | MILLENNIUM MANAGEMENT LLC | 496,555 | 10,130,000 | 0.89% | ||
| 21 | RENAISSANCE TECHNOLOGIES LLC | 474,800 | 9,686,000 | 0.85% | ||
| 22 | EMERALD MUTUAL FUND ADVISERS TRUST | 437,364 | 8,922,000 | 0.79% | ||
| 23 | Point72 Asset Management, L.P. | 431,200 | 8,796,000 | 0.77% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 398,879 | 8,137,000 | 0.72% | ||
| 25 | NORGES BANK | 394,119 | 8,040,000 | 0.71% | ||
| 26 | EVENTIDE ASSET MANAGEMENT, LLC | 393,000 | 8,017,000 | 0.71% | ||
| 27 | VOYA INVESTMENT MANAGEMENT LLC | 356,476 | 7,272,000 | 0.64% | ||
| 28 | WELLS FARGO & COMPANY/MN | 355,928 | 7,261,000 | 0.64% | ||
| 29 | ALLIANCEBERNSTEIN L.P. | 342,283 | 6,983,000 | 0.62% | ||
| 30 | EMERALD ADVISERS, LLC | 338,894 | 6,913,000 | 0.61% | ||
| 31 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 329,314 | 6,718,000 | 0.59% | ||
| 32 | MILLENNIUM MANAGEMENT LLC | 305,000 | 6,222,000 | 0.55% | Call | |
| 33 | MORGAN STANLEY | 291,934 | 5,956,000 | 0.52% | ||
| 34 | FRED ALGER MANAGEMENT, LLC | 266,939 | 5,446,000 | 0.48% | ||
| 35 | BALYASNY ASSET MANAGEMENT L.P. | 266,487 | 5,436,000 | 0.48% | ||
| 36 | GAM Holding AG | 251,136 | 5,123,000 | 0.45% | ||
| 37 | GOLDMAN SACHS GROUP INC | 250,000 | 5,100,000 | 0.45% | Put | |
| 38 | GOLDMAN SACHS GROUP INC | 250,000 | 5,100,000 | 0.45% | Call | |
| 39 | Bank of New York Mellon Corp | 249,949 | 5,099,000 | 0.45% | ||
| 40 | BANK OF AMERICA CORP /DE/ | 240,300 | 4,902,000 | 0.43% | Call | |
| 41 | FIRST MANHATTAN CO. LLC. | 230,300 | 4,698,000 | 0.41% | ||
| 42 | AXA S.A. | 226,427 | 4,619,000 | 0.41% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 217,132 | 4,429,000 | 0.39% | ||
| 44 | HIGHLAND CAPITAL MANAGEMENT LP | 198,700 | 4,053,000 | 0.36% | Call | |
| 45 | Fernwood Investment Management, LLC | 194,852 | 3,975,000 | 0.35% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 186,800 | 3,811,000 | 0.34% | Put | |
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 185,254 | 3,780,000 | 0.33% | ||
| 48 | PUTNAM INVESTMENTS LLC | 183,453 | 3,743,000 | 0.33% | ||
| 49 | Rock Springs Capital Management LP | 175,000 | 3,570,000 | 0.31% | ||
| 50 | BlackRock Investment Management, LLC | 173,046 | 3,530,000 | 0.31% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
