| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JENNISON ASSOCIATES LLC | 3,690,190 | 44,873,000 | 13.77% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 3,037,983 | 36,942,000 | 11.34% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,632,482 | 32,011,000 | 9.83% | ||
| 4 | PFM Health Sciences, LP | 2,381,135 | 28,955,000 | 8.89% | ||
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,025,000 | 24,624,000 | 7.56% | ||
| 6 | TPG Group Holdings (SBS) Advisors, Inc. | 1,237,466 | 15,048,000 | 4.62% | ||
| 7 | FORESITE CAPITAL MANAGEMENT III, LLC | 957,126 | 11,639,000 | 3.57% | ||
| 8 | Foresite Capital Management II, LLC | 949,372 | 11,544,000 | 3.54% | ||
| 9 | VANGUARD GROUP INC | 905,907 | 11,015,000 | 3.38% | ||
| 10 | BlackRock Fund Advisors | 879,783 | 10,698,000 | 3.28% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 652,151 | 7,930,000 | 2.43% | ||
| 12 | STATE STREET CORP | 602,355 | 7,325,000 | 2.25% | ||
| 13 | ALLIANCEBERNSTEIN L.P. | 551,638 | 6,708,000 | 2.06% | ||
| 14 | GOLDMAN SACHS GROUP INC | 420,961 | 5,119,000 | 1.57% | ||
| 15 | WEATHERBIE CAPITAL, LLC | 380,190 | 4,623,000 | 1.42% | ||
| 16 | PUTNAM INVESTMENTS LLC | 319,900 | 3,890,000 | 1.19% | ||
| 17 | BAKER BROS. ADVISORS LP | 299,356 | 3,640,000 | 1.12% | ||
| 18 | NORTHPOINTE CAPITAL LLC | 292,140 | 3,552,000 | 1.09% | ||
| 19 | NORTHERN TRUST CORP | 276,441 | 3,362,000 | 1.03% | ||
| 20 | C WorldWide Group Holding A/S | 192,006 | 2,335,000 | 0.72% | ||
| 21 | WADDELL & REED FINANCIAL INC | 187,700 | 2,282,000 | 0.70% | ||
| 22 | DAFNA Capital Management LLC | 179,769 | 2,186,000 | 0.67% | ||
| 23 | A.R.T. Advisors, LLC | 172,032 | 2,091,000 | 0.64% | ||
| 24 | AMERIPRISE FINANCIAL INC | 170,074 | 2,068,000 | 0.63% | ||
| 25 | Spark Investment Management LLC | 161,900 | 1,968,000 | 0.60% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 161,319 | 1,961,000 | 0.60% | ||
| 27 | RICE HALL JAMES & ASSOCIATES, LLC | 157,023 | 1,909,000 | 0.59% | ||
| 28 | ASYMMETRY CAPITAL MANAGEMENT, L.P. | 140,587 | 1,710,000 | 0.52% | ||
| 29 | COLUMBUS CIRCLE INVESTORS | 140,420 | 1,708,000 | 0.52% | ||
| 30 | Bank of New York Mellon Corp | 130,834 | 1,591,000 | 0.49% | ||
| 31 | STIFEL FINANCIAL CORP | 126,808 | 1,542,000 | 0.47% | ||
| 32 | PLATINUM INVESTMENT MANAGEMENT LTD | 122,000 | 1,483,000 | 0.46% | ||
| 33 | Invesco Ltd. | 113,198 | 1,376,000 | 0.42% | ||
| 34 | BAILARD, INC. | 113,000 | 1,374,000 | 0.42% | ||
| 35 | HARVEY CAPITAL MANAGEMENT INC | 112,500 | 1,368,000 | 0.42% | ||
| 36 | ROYAL BANK OF CANADA | 102,553 | 1,247,000 | 0.38% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 101,709 | 1,237,000 | 0.38% | ||
| 38 | Boulegeris Investments, Inc. | 96,395 | 1,172,000 | 0.36% | ||
| 39 | Nationwide Fund Advisors | 76,983 | 936,000 | 0.29% | ||
| 40 | Iguana Healthcare Management, LLC | 75,000 | 912,000 | 0.28% | ||
| 41 | CREDIT SUISSE AG/ | 74,611 | 908,000 | 0.28% | ||
| 42 | BlackRock Investment Management, LLC | 74,148 | 902,000 | 0.28% | ||
| 43 | BANK OF AMERICA CORP /DE/ | 61,041 | 742,000 | 0.23% | ||
| 44 | NEXTHERA CAPITAL LP | 60,280 | 733,000 | 0.22% | ||
| 45 | CONVECTOR CAPITAL MANAGEMENT, LP | 60,000 | 730,000 | 0.22% | ||
| 46 | KENNEDY CAPITAL MANAGEMENT LLC | 54,296 | 660,000 | 0.20% | ||
| 47 | Benchmark Capital Advisors | 50,500 | 614,000 | 0.19% | ||
| 48 | GOLDMAN SACHS GROUP INC | 49,700 | 604,000 | 0.19% | Put | |
| 49 | GOLDMAN SACHS GROUP INC | 49,700 | 604,000 | 0.19% | Call | |
| 50 | RAYMOND JAMES & ASSOCIATES | 49,152 | 598,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
