| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JENNISON ASSOCIATES LLC | 3,134,916 | 142,168,000 | 9.54% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 2,895,926 | 131,330,000 | 8.81% | ||
| 3 | BlackRock Finance, Inc. | 2,600,888 | 117,951,000 | 7.92% | ||
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,100,000 | 95,235,000 | 6.39% | ||
| 5 | FORESITE CAPITAL MANAGEMENT III, LLC | 1,596,701 | 72,410,000 | 4.86% | ||
| 6 | Foresite Capital Management II, LLC | 1,573,026 | 71,337,000 | 4.79% | ||
| 7 | ORBIMED ADVISORS LLC | 1,496,000 | 67,844,000 | 4.55% | ||
| 8 | VANGUARD GROUP INC | 1,392,525 | 63,151,000 | 4.24% | ||
| 9 | PFM Health Sciences, LP | 1,293,129 | 58,643,000 | 3.94% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 1,086,545 | 49,275,000 | 3.31% | ||
| 11 | Senator Investment Group LP | 800,000 | 36,280,000 | 2.43% | ||
| 12 | DEERFIELD MANAGEMENT COMPANY, L.P. | 795,743 | 36,087,000 | 2.42% | ||
| 13 | STATE STREET CORP | 716,122 | 32,476,000 | 2.18% | ||
| 14 | DEUTSCHE BANK AG\ | 692,159 | 31,387,000 | 2.11% | ||
| 15 | PRICE T ROWE ASSOCIATES INC /MD/ | 438,979 | 19,908,000 | 1.34% | ||
| 16 | Avoro Capital Advisors LLC | 425,000 | 19,274,000 | 1.29% | ||
| 17 | CITADEL ADVISORS LLC | 422,289 | 19,151,000 | 1.29% | ||
| 18 | ALLIANCEBERNSTEIN L.P. | 421,642 | 19,121,000 | 1.28% | ||
| 19 | SECTORAL ASSET MANAGEMENT INC | 389,423 | 17,660,000 | 1.19% | ||
| 20 | NORTHERN TRUST CORP | 379,862 | 17,227,000 | 1.16% | ||
| 21 | FRED ALGER MANAGEMENT, LLC | 367,657 | 16,673,000 | 1.12% | ||
| 22 | AMERIPRISE FINANCIAL INC | 358,167 | 16,238,000 | 1.09% | ||
| 23 | FMR LLC | 320,500 | 14,535,000 | 0.98% | ||
| 24 | Invesco Ltd. | 307,339 | 13,937,000 | 0.94% | ||
| 25 | BAKER BROS. ADVISORS LP | 299,356 | 13,576,000 | 0.91% | ||
| 26 | COLUMBUS CIRCLE INVESTORS | 282,309 | 12,803,000 | 0.86% | ||
| 27 | VOYA INVESTMENT MANAGEMENT LLC | 280,710 | 12,730,000 | 0.85% | ||
| 28 | Bank of New York Mellon Corp | 265,076 | 12,021,000 | 0.81% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 262,221 | 11,891,000 | 0.80% | ||
| 30 | TWO SIGMA INVESTMENTS, LP | 253,190 | 11,482,000 | 0.77% | ||
| 31 | GOLDMAN SACHS GROUP INC | 223,053 | 10,115,000 | 0.68% | ||
| 32 | Ghost Tree Capital, LLC | 220,000 | 9,977,000 | 0.67% | Call | |
| 33 | CITIGROUP INC | 203,277 | 9,218,000 | 0.62% | ||
| 34 | RICE HALL JAMES & ASSOCIATES, LLC | 198,313 | 8,993,000 | 0.60% | ||
| 35 | WADDELL & REED FINANCIAL INC | 192,100 | 8,712,000 | 0.58% | ||
| 36 | NORTHPOINTE CAPITAL LLC | 163,324 | 7,407,000 | 0.50% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 136,106 | 6,173,000 | 0.41% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 124,200 | 5,632,000 | 0.38% | Call | |
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 114,457 | 5,191,000 | 0.35% | ||
| 40 | THRIVENT FINANCIAL FOR LUTHERANS | 109,130 | 4,949,000 | 0.33% | ||
| 41 | Atika Capital Management LLC | 95,000 | 4,308,000 | 0.29% | ||
| 42 | Informed Momentum Co LLC | 92,963 | 4,216,000 | 0.28% | ||
| 43 | MORGAN STANLEY | 92,624 | 4,201,000 | 0.28% | ||
| 44 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 90,900 | 4,122,000 | 0.28% | ||
| 45 | ROYAL BANK OF CANADA | 89,083 | 4,040,000 | 0.27% | ||
| 46 | ESSEX INVESTMENT MANAGEMENT CO LLC | 87,662 | 3,975,000 | 0.27% | ||
| 47 | STIFEL FINANCIAL CORP | 87,601 | 3,973,000 | 0.27% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 85,900 | 3,896,000 | 0.26% | Put | |
| 49 | Rhenman & Partners Asset Management AB | 85,000 | 3,855,000 | 0.26% | ||
| 50 | Iguana Healthcare Management, LLC | 85,000 | 3,855,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
