| # | % | |||||
|---|---|---|---|---|---|---|
| 151 | SECTORAL ASSET MANAGEMENT INC | 389,423 | 17,660,000 | 1.19% | ||
| 152 | ALLIANCEBERNSTEIN L.P. | 421,642 | 19,121,000 | 1.28% | ||
| 153 | CITADEL ADVISORS LLC | 422,289 | 19,151,000 | 1.29% | ||
| 154 | Avoro Capital Advisors LLC | 425,000 | 19,274,000 | 1.29% | ||
| 155 | PRICE T ROWE ASSOCIATES INC /MD/ | 438,979 | 19,908,000 | 1.34% | ||
| 156 | DEUTSCHE BANK AG\ | 692,159 | 31,387,000 | 2.11% | ||
| 157 | STATE STREET CORP | 716,122 | 32,476,000 | 2.18% | ||
| 158 | DEERFIELD MANAGEMENT COMPANY, L.P. | 795,743 | 36,087,000 | 2.42% | ||
| 159 | Senator Investment Group LP | 800,000 | 36,280,000 | 2.43% | ||
| 160 | MILLENNIUM MANAGEMENT LLC | 1,086,545 | 49,275,000 | 3.31% | ||
| 161 | PFM Health Sciences, LP | 1,293,129 | 58,643,000 | 3.94% | ||
| 162 | VANGUARD GROUP INC | 1,392,525 | 63,151,000 | 4.24% | ||
| 163 | ORBIMED ADVISORS LLC | 1,496,000 | 67,844,000 | 4.55% | ||
| 164 | Foresite Capital Management II, LLC | 1,573,026 | 71,337,000 | 4.79% | ||
| 165 | FORESITE CAPITAL MANAGEMENT III, LLC | 1,596,701 | 72,410,000 | 4.86% | ||
| 166 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,100,000 | 95,235,000 | 6.39% | ||
| 167 | BlackRock Finance, Inc. | 2,600,888 | 117,951,000 | 7.92% | ||
| 168 | WELLINGTON MANAGEMENT GROUP LLP | 2,895,926 | 131,330,000 | 8.81% | ||
| 169 | JENNISON ASSOCIATES LLC | 3,134,916 | 142,168,000 | 9.54% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
